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Vascular and lung function related to ultrafine and fine particles exposure assessed by personal and indoor monitoring: a cross-sectional study

Olsen, Yulia; Karottki, Dorina Gabriela; Jensen, Ditte Marie; Bekoe, Gabriel; Kjeldsen, Birthe Uldahl; Clausen, Geo; Hersoug, Lars-Georg; Holst, Gitte Juel; Wierzbicka, Aneta LU and Sigsgaard, Torben, et al. (2014) In Environmental Health 13.
Abstract
Background: Exposure to ambient air particulate matter (PM) has been linked to decline in pulmonary function and cardiovascular events possibly through inflammation. Little is known about individual exposure to ultrafine particles (UFP) inside and outside modern homes and associated health-related effects. Methods: Associations between vascular and lung function, inflammation markers and exposure in terms of particle number concentration (PNC; d = 10-300 nm) were studied in a cross-sectional design with personal and home indoor monitoring in the Western Copenhagen Area, Denmark. During 48-h, PNC and PM2.5 were monitored in living rooms of 60 homes with 81 non-smoking subjects (30-75 years old), 59 of whom carried personal monitors both... (More)
Background: Exposure to ambient air particulate matter (PM) has been linked to decline in pulmonary function and cardiovascular events possibly through inflammation. Little is known about individual exposure to ultrafine particles (UFP) inside and outside modern homes and associated health-related effects. Methods: Associations between vascular and lung function, inflammation markers and exposure in terms of particle number concentration (PNC; d = 10-300 nm) were studied in a cross-sectional design with personal and home indoor monitoring in the Western Copenhagen Area, Denmark. During 48-h, PNC and PM2.5 were monitored in living rooms of 60 homes with 81 non-smoking subjects (30-75 years old), 59 of whom carried personal monitors both when at home and away from home. We measured lung function in terms of the FEV1/FVC ratio, microvascular function (MVF) and pulse amplitude by digital artery tonometry, blood pressure and biomarkers of inflammation including C-reactive protein, and leukocyte counts with subdivision in neutrophils, eosinophils, monocytes, and lymphocytes in blood. Results: PNC from personal and stationary home monitoring showed weak correlation (r = 0.15, p = 0.24). Personal UFP exposure away from home was significantly inversely associated with MVF (1.3% decline per interquartile range, 95% confidence interval: 0.1-2.5%) and pulse amplitude and positively associated with leukocyte and neutrophil counts. The leukocyte and neutrophil counts were also positively and pulse amplitude negatively associated with total personal PNC. Indoor PNC and PM2.5 showed positive association with blood pressure and inverse association with eosinophil counts. Conclusions: The inverse association between personal exposure away from home and MVF is consistent with adverse health effects of UFP from sources outside the home and might be related to increased inflammation indicated by leukocyte counts, whereas UFP from sources in the home could have less effect. (Less)
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keywords
Indoor air pollution, Ambient air pollution, Ultrafine particles, Personal monitoring, Microvascular function, Inflammation, Lung function
in
Environmental Health
volume
13
publisher
BioMed Central
external identifiers
  • wos:000347006400001
  • scopus:84988693970
ISSN
1476-069X
DOI
10.1186/1476-069X-13-112
language
English
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yes
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c67f917d-f1cf-4b7d-8bc2-4644fd15cde9 (old id 5085303)
date added to LUP
2015-02-24 15:23:22
date last changed
2017-09-17 06:50:02
@article{c67f917d-f1cf-4b7d-8bc2-4644fd15cde9,
  abstract     = {Background: Exposure to ambient air particulate matter (PM) has been linked to decline in pulmonary function and cardiovascular events possibly through inflammation. Little is known about individual exposure to ultrafine particles (UFP) inside and outside modern homes and associated health-related effects. Methods: Associations between vascular and lung function, inflammation markers and exposure in terms of particle number concentration (PNC; d = 10-300 nm) were studied in a cross-sectional design with personal and home indoor monitoring in the Western Copenhagen Area, Denmark. During 48-h, PNC and PM2.5 were monitored in living rooms of 60 homes with 81 non-smoking subjects (30-75 years old), 59 of whom carried personal monitors both when at home and away from home. We measured lung function in terms of the FEV1/FVC ratio, microvascular function (MVF) and pulse amplitude by digital artery tonometry, blood pressure and biomarkers of inflammation including C-reactive protein, and leukocyte counts with subdivision in neutrophils, eosinophils, monocytes, and lymphocytes in blood. Results: PNC from personal and stationary home monitoring showed weak correlation (r = 0.15, p = 0.24). Personal UFP exposure away from home was significantly inversely associated with MVF (1.3% decline per interquartile range, 95% confidence interval: 0.1-2.5%) and pulse amplitude and positively associated with leukocyte and neutrophil counts. The leukocyte and neutrophil counts were also positively and pulse amplitude negatively associated with total personal PNC. Indoor PNC and PM2.5 showed positive association with blood pressure and inverse association with eosinophil counts. Conclusions: The inverse association between personal exposure away from home and MVF is consistent with adverse health effects of UFP from sources outside the home and might be related to increased inflammation indicated by leukocyte counts, whereas UFP from sources in the home could have less effect.},
  articleno    = {112},
  author       = {Olsen, Yulia and Karottki, Dorina Gabriela and Jensen, Ditte Marie and Bekoe, Gabriel and Kjeldsen, Birthe Uldahl and Clausen, Geo and Hersoug, Lars-Georg and Holst, Gitte Juel and Wierzbicka, Aneta and Sigsgaard, Torben and Linneberg, Allan and Moller, Peter and Loft, Steffen},
  issn         = {1476-069X},
  keyword      = {Indoor air pollution,Ambient air pollution,Ultrafine particles,Personal monitoring,Microvascular function,Inflammation,Lung function},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Environmental Health},
  title        = {Vascular and lung function related to ultrafine and fine particles exposure assessed by personal and indoor monitoring: a cross-sectional study},
  url          = {http://dx.doi.org/10.1186/1476-069X-13-112},
  volume       = {13},
  year         = {2014},
}