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Improved methods for pancreatic islet transplantation

da Cunha, Joao Paulo LU orcid ; Gysemans, Conny and Mathieu, Chantal (2016) WO2016177859A1
Abstract
The present invention provides methods that increases the graft survival rate of pancreatic islets after pancreatic islet transplantation, maintains the survival of pancreatic islets ex vivo, and reduce the number of transplanted pancreatic islets required for normalizing blood glucose levels. When performing pancreatic islet transplantation, by pre-incubating pancreatic islets with stem cells or by transplanting pancreatic islets and stem cells in contact with each other, it is possible to significantly improve graft survival rate of transplanted pancreatic islets and reduce the number of transplanted pancreatic islets required for normalizing blood glucose levels. The invention also provides compositions for pancreatic islet... (More)
The present invention provides methods that increases the graft survival rate of pancreatic islets after pancreatic islet transplantation, maintains the survival of pancreatic islets ex vivo, and reduce the number of transplanted pancreatic islets required for normalizing blood glucose levels. When performing pancreatic islet transplantation, by pre-incubating pancreatic islets with stem cells or by transplanting pancreatic islets and stem cells in contact with each other, it is possible to significantly improve graft survival rate of transplanted pancreatic islets and reduce the number of transplanted pancreatic islets required for normalizing blood glucose levels. The invention also provides compositions for pancreatic islet transplantation comprising the islets and the stem cells or conditioned medium from stem cell culture islets. Thus, the composition and methods are useful for treating diabetes.
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inventor
LU orcid ; Gysemans, Conny and Mathieu, Chantal
publishing date
type
Patent
publication status
published
subject
patent number
WO2016177859A1
language
English
LU publication?
no
id
508d82f7-3b29-4a51-aed0-7321c67daaa7
date added to LUP
2019-10-20 12:46:14
date last changed
2020-01-08 02:32:52
@misc{508d82f7-3b29-4a51-aed0-7321c67daaa7,
  abstract     = {{The present invention provides methods that increases the graft survival rate of pancreatic islets after pancreatic islet transplantation, maintains the survival of pancreatic islets ex vivo, and reduce the number of transplanted pancreatic islets required for normalizing blood glucose levels. When performing pancreatic islet transplantation, by pre-incubating pancreatic islets with stem cells or by transplanting pancreatic islets and stem cells in contact with each other, it is possible to significantly improve graft survival rate of transplanted pancreatic islets and reduce the number of transplanted pancreatic islets required for normalizing blood glucose levels. The invention also provides compositions for pancreatic islet transplantation comprising the islets and the stem cells or conditioned medium from stem cell culture islets. Thus, the composition and methods are useful for treating diabetes.<br/>}},
  author       = {{da Cunha, Joao Paulo and Gysemans, Conny and Mathieu, Chantal}},
  language     = {{eng}},
  month        = {{10}},
  note         = {{Patent, Patent Number: WO2016177859A1}},
  title        = {{Improved methods for pancreatic islet transplantation}},
  year         = {{2016}},
}