Relationships between tissue composition and viscoelastic properties in human trabecular bone.
Ojanen, X ; Isaksson, Hanna LU
; Töyräs, J
; Turunen, M J
; Malo, M K H
; Halvari, A
and Jurvelin, J S
(2015)
In Journal of Biomechanics
48(2).
p.269-275
- Abstract
- Trabecular bone is a metabolically active tissue with a high surface to volume ratio. It exhibits viscoelastic properties that may change during aging. Changes in bone properties due to altered metabolism are sensitively revealed in trabecular bone. However, the relationships between material composition and viscoelastic properties of bone, and their changes during aging have not yet been elucidated. In this study, trabecular bone samples from the femoral neck of male cadavers (n=21) aged 17-82 years were collected and the tissue level composition and its associations with the tissue viscoelastic properties were evaluated by using Raman microspectroscopy and nanoindentation, respectively. For composition, collagen content, mineralization,... (More)
- Trabecular bone is a metabolically active tissue with a high surface to volume ratio. It exhibits viscoelastic properties that may change during aging. Changes in bone properties due to altered metabolism are sensitively revealed in trabecular bone. However, the relationships between material composition and viscoelastic properties of bone, and their changes during aging have not yet been elucidated. In this study, trabecular bone samples from the femoral neck of male cadavers (n=21) aged 17-82 years were collected and the tissue level composition and its associations with the tissue viscoelastic properties were evaluated by using Raman microspectroscopy and nanoindentation, respectively. For composition, collagen content, mineralization, carbonate substitution and mineral crystallinity were evaluated. The calculated mechanical properties included reduced modulus (Er), hardness (H) and the creep parameters (E1, E2, η1and η2), as obtained by fitting the experimental data to the Burgers model. The results indicated that the creep parameters, E1, E2, η1and η2, were linearly correlated with mineral crystallinity (r=0.769-0.924, p<0.001). Creep time constant (η2/E2) tended to increase with crystallinity (r=0.422, p=0.057). With age, the mineralization decreased (r=-0.587, p=0.005) while the carbonate substitution increased (r=0.728, p<0.001). Age showed no significant associations with nanoindentation parameters. The present findings suggest that, at the tissue-level, the viscoelastic properties of trabecular bone are related to the changes in characteristics of bone mineral. This association may be independent of human age. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4908523
- author
- Ojanen, X
; Isaksson, Hanna
LU
; Töyräs, J
; Turunen, M J
; Malo, M K H
; Halvari, A
and Jurvelin, J S
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Biomechanics
- volume
- 48
- issue
- 2
- pages
- 269 - 275
- publisher
- Elsevier
- external identifiers
-
- pmid:25498367
- wos:000349194800012
- scopus:84920131366
- pmid:25498367
- ISSN
- 1873-2380
- DOI
- 10.1016/j.jbiomech.2014.11.034
- language
- English
- LU publication?
- yes
- id
- 5091bdd9-cb8a-499a-8e38-e8d0dd0d1005 (old id 4908523)
- date added to LUP
- 2016-04-01 09:49:03
- date last changed
- 2023-08-30 10:33:36
@article{5091bdd9-cb8a-499a-8e38-e8d0dd0d1005,
abstract = {{Trabecular bone is a metabolically active tissue with a high surface to volume ratio. It exhibits viscoelastic properties that may change during aging. Changes in bone properties due to altered metabolism are sensitively revealed in trabecular bone. However, the relationships between material composition and viscoelastic properties of bone, and their changes during aging have not yet been elucidated. In this study, trabecular bone samples from the femoral neck of male cadavers (n=21) aged 17-82 years were collected and the tissue level composition and its associations with the tissue viscoelastic properties were evaluated by using Raman microspectroscopy and nanoindentation, respectively. For composition, collagen content, mineralization, carbonate substitution and mineral crystallinity were evaluated. The calculated mechanical properties included reduced modulus (Er), hardness (H) and the creep parameters (E1, E2, η1and η2), as obtained by fitting the experimental data to the Burgers model. The results indicated that the creep parameters, E1, E2, η1and η2, were linearly correlated with mineral crystallinity (r=0.769-0.924, p<0.001). Creep time constant (η2/E2) tended to increase with crystallinity (r=0.422, p=0.057). With age, the mineralization decreased (r=-0.587, p=0.005) while the carbonate substitution increased (r=0.728, p<0.001). Age showed no significant associations with nanoindentation parameters. The present findings suggest that, at the tissue-level, the viscoelastic properties of trabecular bone are related to the changes in characteristics of bone mineral. This association may be independent of human age.}},
author = {{Ojanen, X and Isaksson, Hanna and Töyräs, J and Turunen, M J and Malo, M K H and Halvari, A and Jurvelin, J S}},
issn = {{1873-2380}},
language = {{eng}},
number = {{2}},
pages = {{269--275}},
publisher = {{Elsevier}},
series = {{Journal of Biomechanics}},
title = {{Relationships between tissue composition and viscoelastic properties in human trabecular bone.}},
url = {{http://dx.doi.org/10.1016/j.jbiomech.2014.11.034}},
doi = {{10.1016/j.jbiomech.2014.11.034}},
volume = {{48}},
year = {{2015}},
}