The role of gastric mucosal histamine in acid secretion and experimentally induced lesions in the rat. Digestion 1990;46:1-9.
(1990) In Digestion 46(1). p.1-9- Abstract
- The role played by histamine from enterochromaffin-like (ECL) cells and mast cells in gastric acid secretion and in the development of ethanol-induced gastric lesions was studied in the rat. This was done by examining the effects of inhibition of the histamine-producing enzyme histidine decarboxylase (HDC) with alpha-fluoromethylhistidine (alpha-FMH) and the effects of degranulation of the mucosal mast cells with dexamethasone. A single dose of alpha-FMH (50 mg/kg p.o.) inhibited the HDC activity by 94% but did not affect histamine levels in the gastric mucosa 2 h after dose. Repeated treatment resulted in an almost complete inhibition of HDC activity and in a reduction of histamine levels by 75%. Pentagastrin failed to stimulate acid... (More)
- The role played by histamine from enterochromaffin-like (ECL) cells and mast cells in gastric acid secretion and in the development of ethanol-induced gastric lesions was studied in the rat. This was done by examining the effects of inhibition of the histamine-producing enzyme histidine decarboxylase (HDC) with alpha-fluoromethylhistidine (alpha-FMH) and the effects of degranulation of the mucosal mast cells with dexamethasone. A single dose of alpha-FMH (50 mg/kg p.o.) inhibited the HDC activity by 94% but did not affect histamine levels in the gastric mucosa 2 h after dose. Repeated treatment resulted in an almost complete inhibition of HDC activity and in a reduction of histamine levels by 75%. Pentagastrin failed to stimulate acid secretion after 4 days treatment with alpha-FMH, whereas the acid response to histamine was unaffected in chronic gastric fistula rats. Ethanol failed to induce gastric lesions in rats pretreated for 4 days with dexamethasone whereas 4 days pretreatment with alpha-FMH did not influence ethanol-induced lesion formation. The present results show that histamine synthesis is required for pentagastrin-stimulated gastric acid secretion and that mucosal mast-cell histamine plays a role in the development of ethanol-induced gastric lesions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/30179
- author
- Andersson, K ; Mattsson, H and Larsson, H
- publishing date
- 1990
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Digestion
- volume
- 46
- issue
- 1
- pages
- 1 - 9
- publisher
- Karger
- external identifiers
-
- scopus:0025171083
- ISSN
- 1421-9867
- language
- English
- LU publication?
- no
- id
- 50d33a30-397b-47b1-9b59-bfa772de0324 (old id 30179)
- date added to LUP
- 2016-04-01 11:54:37
- date last changed
- 2021-01-03 09:44:44
@article{50d33a30-397b-47b1-9b59-bfa772de0324,
abstract = {{The role played by histamine from enterochromaffin-like (ECL) cells and mast cells in gastric acid secretion and in the development of ethanol-induced gastric lesions was studied in the rat. This was done by examining the effects of inhibition of the histamine-producing enzyme histidine decarboxylase (HDC) with alpha-fluoromethylhistidine (alpha-FMH) and the effects of degranulation of the mucosal mast cells with dexamethasone. A single dose of alpha-FMH (50 mg/kg p.o.) inhibited the HDC activity by 94% but did not affect histamine levels in the gastric mucosa 2 h after dose. Repeated treatment resulted in an almost complete inhibition of HDC activity and in a reduction of histamine levels by 75%. Pentagastrin failed to stimulate acid secretion after 4 days treatment with alpha-FMH, whereas the acid response to histamine was unaffected in chronic gastric fistula rats. Ethanol failed to induce gastric lesions in rats pretreated for 4 days with dexamethasone whereas 4 days pretreatment with alpha-FMH did not influence ethanol-induced lesion formation. The present results show that histamine synthesis is required for pentagastrin-stimulated gastric acid secretion and that mucosal mast-cell histamine plays a role in the development of ethanol-induced gastric lesions.}},
author = {{Andersson, K and Mattsson, H and Larsson, H}},
issn = {{1421-9867}},
language = {{eng}},
number = {{1}},
pages = {{1--9}},
publisher = {{Karger}},
series = {{Digestion}},
title = {{The role of gastric mucosal histamine in acid secretion and experimentally induced lesions in the rat. Digestion 1990;46:1-9.}},
volume = {{46}},
year = {{1990}},
}