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Heparin for the treatment of thrombosis in preterm and term neonates

Romantsik, Olga LU ; Bruschettini, Matteo LU ; Zappettini, Simona; Ramenghi, Luca Antonio and Calevo, Maria Grazia (2016) In Cochrane Database of Systematic Reviews 2016(5).
Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows: To assess whether heparin treatment (both UFH and LMWH) in preterm and term newborn infants with diagnosed thrombosis reduces the rate of mortality and morbidity. The intervention will be compared to placebo or no treatment. In addition, the safety of heparin therapy (both UFH and LMWH) will be assessed for potential harms. Subgroup analyses will be performed regarding gestational age, birth weight, mode of thrombus diagnosis, presence of central line, positive family history for genetic disorders (thrombophilia, deficiency of protein S and protein C, MTHFR mutation), route of heparin administration, type of heparin used, and location of thrombus... (More)

This is the protocol for a review and there is no abstract. The objectives are as follows: To assess whether heparin treatment (both UFH and LMWH) in preterm and term newborn infants with diagnosed thrombosis reduces the rate of mortality and morbidity. The intervention will be compared to placebo or no treatment. In addition, the safety of heparin therapy (both UFH and LMWH) will be assessed for potential harms. Subgroup analyses will be performed regarding gestational age, birth weight, mode of thrombus diagnosis, presence of central line, positive family history for genetic disorders (thrombophilia, deficiency of protein S and protein C, MTHFR mutation), route of heparin administration, type of heparin used, and location of thrombus (see Subgroup analysis and investigation of heterogeneity).

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cochrane Database of Systematic Reviews
volume
2016
issue
5
publisher
Wiley-Blackwell
external identifiers
  • scopus:84965048628
ISSN
1469-493X
DOI
10.1002/14651858.CD012185
language
English
LU publication?
yes
id
50fcce37-dfd9-4f30-bd79-e553ddc8ff92
date added to LUP
2016-05-31 15:06:48
date last changed
2017-01-01 08:27:11
@article{50fcce37-dfd9-4f30-bd79-e553ddc8ff92,
  abstract     = {<p>This is the protocol for a review and there is no abstract. The objectives are as follows: To assess whether heparin treatment (both UFH and LMWH) in preterm and term newborn infants with diagnosed thrombosis reduces the rate of mortality and morbidity. The intervention will be compared to placebo or no treatment. In addition, the safety of heparin therapy (both UFH and LMWH) will be assessed for potential harms. Subgroup analyses will be performed regarding gestational age, birth weight, mode of thrombus diagnosis, presence of central line, positive family history for genetic disorders (thrombophilia, deficiency of protein S and protein C, MTHFR mutation), route of heparin administration, type of heparin used, and location of thrombus (see Subgroup analysis and investigation of heterogeneity).</p>},
  articleno    = {CD012185},
  author       = {Romantsik, Olga and Bruschettini, Matteo and Zappettini, Simona and Ramenghi, Luca Antonio and Calevo, Maria Grazia},
  issn         = {1469-493X},
  language     = {eng},
  month        = {05},
  number       = {5},
  publisher    = {Wiley-Blackwell},
  series       = {Cochrane Database of Systematic Reviews},
  title        = {Heparin for the treatment of thrombosis in preterm and term neonates},
  url          = {http://dx.doi.org/10.1002/14651858.CD012185},
  volume       = {2016},
  year         = {2016},
}