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Activation of fibrinolysis and coagulation in non-occlusive intestinal ischaemia in a pig model

Acosta, Stefan LU orcid ; Nilsson, Torbjorn K. ; Bergqvist, David and Björck, Martin (2004) In Blood Coagulation and Fibrinolysis 15(1). p.69-76
Abstract
The present study was carried out to explore the dynamics of the fibrinolytic and coagulation systems during non-occlusive intestinal ischaemia in a porcine model. Nineteen pigs underwent laparotomy. The inferior mesenteric artery and the collateral vessels to the rectum were ligated. The superior mesenteric artery (SMA) was isolated at its origin from the aorta, and constriction and flowmeter devices were applied. The blood flow of the SMA was reduced to cause ischaemia in the distal colon within the pHi interval 6.9-7.1. Fibrinogen, soluble fibrin, D-dimer, tissue plasminogen activator/plasminogen activator inhibitor-1 (tPA/PAI-1) complex and albumin were measured. Corrections for pig D-dimer and albumin were performed. Fibrinogen... (More)
The present study was carried out to explore the dynamics of the fibrinolytic and coagulation systems during non-occlusive intestinal ischaemia in a porcine model. Nineteen pigs underwent laparotomy. The inferior mesenteric artery and the collateral vessels to the rectum were ligated. The superior mesenteric artery (SMA) was isolated at its origin from the aorta, and constriction and flowmeter devices were applied. The blood flow of the SMA was reduced to cause ischaemia in the distal colon within the pHi interval 6.9-7.1. Fibrinogen, soluble fibrin, D-dimer, tissue plasminogen activator/plasminogen activator inhibitor-1 (tPA/PAI-1) complex and albumin were measured. Corrections for pig D-dimer and albumin were performed. Fibrinogen decreased significantly after laparotomy (P < 0.0001) and further after constriction of the SMA (P < 0.05), whereas soluble fibrin increased significantly (P < 0.005) after constriction of the SMA. The tPA/PAI-1 complex increased significantly after laparotomy (P < 0.05) and, after constriction of the SMA, the values first tended to decrease (P = 0.06) and then to increase (P = 0.056). The need to calibrate assays of human plasma proteins when applying them to experimental pig models was demonstrated. After constriction of the SMA, there was a rapidly reversed peak in the coagulation marker soluble fibrin and a strong tendency of alteration of the fibrinolytic marker tPA/PAI-1 complex. (Less)
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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood Coagulation and Fibrinolysis
volume
15
issue
1
pages
69 - 76
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:2042479400
ISSN
1473-5733
DOI
10.1097/00001721-200401000-00011
language
English
LU publication?
no
id
51011e5e-370a-4b10-8213-76911a3b10d8
date added to LUP
2020-12-14 14:52:51
date last changed
2022-04-26 22:52:43
@article{51011e5e-370a-4b10-8213-76911a3b10d8,
  abstract     = {{The present study was carried out to explore the dynamics of the fibrinolytic and coagulation systems during non-occlusive intestinal ischaemia in a porcine model. Nineteen pigs underwent laparotomy. The inferior mesenteric artery and the collateral vessels to the rectum were ligated. The superior mesenteric artery (SMA) was isolated at its origin from the aorta, and constriction and flowmeter devices were applied. The blood flow of the SMA was reduced to cause ischaemia in the distal colon within the pHi interval 6.9-7.1. Fibrinogen, soluble fibrin, D-dimer, tissue plasminogen activator/plasminogen activator inhibitor-1 (tPA/PAI-1) complex and albumin were measured. Corrections for pig D-dimer and albumin were performed. Fibrinogen decreased significantly after laparotomy (P &lt; 0.0001) and further after constriction of the SMA (P &lt; 0.05), whereas soluble fibrin increased significantly (P &lt; 0.005) after constriction of the SMA. The tPA/PAI-1 complex increased significantly after laparotomy (P &lt; 0.05) and, after constriction of the SMA, the values first tended to decrease (P = 0.06) and then to increase (P = 0.056). The need to calibrate assays of human plasma proteins when applying them to experimental pig models was demonstrated. After constriction of the SMA, there was a rapidly reversed peak in the coagulation marker soluble fibrin and a strong tendency of alteration of the fibrinolytic marker tPA/PAI-1 complex.}},
  author       = {{Acosta, Stefan and Nilsson, Torbjorn K. and Bergqvist, David and Björck, Martin}},
  issn         = {{1473-5733}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{69--76}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Blood Coagulation and Fibrinolysis}},
  title        = {{Activation of fibrinolysis and coagulation in non-occlusive intestinal ischaemia in a pig model}},
  url          = {{http://dx.doi.org/10.1097/00001721-200401000-00011}},
  doi          = {{10.1097/00001721-200401000-00011}},
  volume       = {{15}},
  year         = {{2004}},
}