Activation of fibrinolysis and coagulation in non-occlusive intestinal ischaemia in a pig model
(2004) In Blood Coagulation and Fibrinolysis 15(1). p.69-76- Abstract
- The present study was carried out to explore the dynamics of the fibrinolytic and coagulation systems during non-occlusive intestinal ischaemia in a porcine model. Nineteen pigs underwent laparotomy. The inferior mesenteric artery and the collateral vessels to the rectum were ligated. The superior mesenteric artery (SMA) was isolated at its origin from the aorta, and constriction and flowmeter devices were applied. The blood flow of the SMA was reduced to cause ischaemia in the distal colon within the pHi interval 6.9-7.1. Fibrinogen, soluble fibrin, D-dimer, tissue plasminogen activator/plasminogen activator inhibitor-1 (tPA/PAI-1) complex and albumin were measured. Corrections for pig D-dimer and albumin were performed. Fibrinogen... (More)
- The present study was carried out to explore the dynamics of the fibrinolytic and coagulation systems during non-occlusive intestinal ischaemia in a porcine model. Nineteen pigs underwent laparotomy. The inferior mesenteric artery and the collateral vessels to the rectum were ligated. The superior mesenteric artery (SMA) was isolated at its origin from the aorta, and constriction and flowmeter devices were applied. The blood flow of the SMA was reduced to cause ischaemia in the distal colon within the pHi interval 6.9-7.1. Fibrinogen, soluble fibrin, D-dimer, tissue plasminogen activator/plasminogen activator inhibitor-1 (tPA/PAI-1) complex and albumin were measured. Corrections for pig D-dimer and albumin were performed. Fibrinogen decreased significantly after laparotomy (P < 0.0001) and further after constriction of the SMA (P < 0.05), whereas soluble fibrin increased significantly (P < 0.005) after constriction of the SMA. The tPA/PAI-1 complex increased significantly after laparotomy (P < 0.05) and, after constriction of the SMA, the values first tended to decrease (P = 0.06) and then to increase (P = 0.056). The need to calibrate assays of human plasma proteins when applying them to experimental pig models was demonstrated. After constriction of the SMA, there was a rapidly reversed peak in the coagulation marker soluble fibrin and a strong tendency of alteration of the fibrinolytic marker tPA/PAI-1 complex. (Less)
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https://lup.lub.lu.se/record/51011e5e-370a-4b10-8213-76911a3b10d8
- author
- Acosta, Stefan LU ; Nilsson, Torbjorn K. ; Bergqvist, David and Björck, Martin
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood Coagulation and Fibrinolysis
- volume
- 15
- issue
- 1
- pages
- 69 - 76
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:2042479400
- ISSN
- 1473-5733
- DOI
- 10.1097/00001721-200401000-00011
- language
- English
- LU publication?
- no
- id
- 51011e5e-370a-4b10-8213-76911a3b10d8
- date added to LUP
- 2020-12-14 14:52:51
- date last changed
- 2022-04-26 22:52:43
@article{51011e5e-370a-4b10-8213-76911a3b10d8, abstract = {{The present study was carried out to explore the dynamics of the fibrinolytic and coagulation systems during non-occlusive intestinal ischaemia in a porcine model. Nineteen pigs underwent laparotomy. The inferior mesenteric artery and the collateral vessels to the rectum were ligated. The superior mesenteric artery (SMA) was isolated at its origin from the aorta, and constriction and flowmeter devices were applied. The blood flow of the SMA was reduced to cause ischaemia in the distal colon within the pHi interval 6.9-7.1. Fibrinogen, soluble fibrin, D-dimer, tissue plasminogen activator/plasminogen activator inhibitor-1 (tPA/PAI-1) complex and albumin were measured. Corrections for pig D-dimer and albumin were performed. Fibrinogen decreased significantly after laparotomy (P < 0.0001) and further after constriction of the SMA (P < 0.05), whereas soluble fibrin increased significantly (P < 0.005) after constriction of the SMA. The tPA/PAI-1 complex increased significantly after laparotomy (P < 0.05) and, after constriction of the SMA, the values first tended to decrease (P = 0.06) and then to increase (P = 0.056). The need to calibrate assays of human plasma proteins when applying them to experimental pig models was demonstrated. After constriction of the SMA, there was a rapidly reversed peak in the coagulation marker soluble fibrin and a strong tendency of alteration of the fibrinolytic marker tPA/PAI-1 complex.}}, author = {{Acosta, Stefan and Nilsson, Torbjorn K. and Bergqvist, David and Björck, Martin}}, issn = {{1473-5733}}, language = {{eng}}, number = {{1}}, pages = {{69--76}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Blood Coagulation and Fibrinolysis}}, title = {{Activation of fibrinolysis and coagulation in non-occlusive intestinal ischaemia in a pig model}}, url = {{http://dx.doi.org/10.1097/00001721-200401000-00011}}, doi = {{10.1097/00001721-200401000-00011}}, volume = {{15}}, year = {{2004}}, }