Cerebral energy metabolism and microdialysis in neurocritical care.
(2010) In Child's Nervous System 26. p.465-472- Abstract
- It is of obvious clinical importance to monitor cerebral metabolism-in particular, cerebral energy metabolism and indicators of cellular damage-online at the bedside. The technique of cerebral microdialysis provides the opportunity for continuous monitoring of metabolic changes in the tissue before they are reflected in peripheral blood chemistry or in systemic physiological parameters. The basic idea of microdialysis is to mimic the function of a blood capillary by positioning a thin dialysis tube in the tissue and to be used to analyze the chemical composition of the interstitial fluid. The biochemical variables used during routine monitoring were chosen to cover important aspects of cerebral energy metabolism (glucose, pyruvate and... (More)
- It is of obvious clinical importance to monitor cerebral metabolism-in particular, cerebral energy metabolism and indicators of cellular damage-online at the bedside. The technique of cerebral microdialysis provides the opportunity for continuous monitoring of metabolic changes in the tissue before they are reflected in peripheral blood chemistry or in systemic physiological parameters. The basic idea of microdialysis is to mimic the function of a blood capillary by positioning a thin dialysis tube in the tissue and to be used to analyze the chemical composition of the interstitial fluid. The biochemical variables used during routine monitoring were chosen to cover important aspects of cerebral energy metabolism (glucose, pyruvate and lactate), to indicate excessive interstitial levels of excitatory transmitter substance (glutamate) and to give indications of degradation of cellular membranes (glycerol). Furthermore, pharmokinetic studies can be conducted using microdialysis. This article discusses technical and physiological aspects of microdialysis, and its clinical applications in brain injury. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1511562
- author
- Nordström, Carl-Henrik LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Child's Nervous System
- volume
- 26
- pages
- 465 - 472
- publisher
- Springer
- external identifiers
-
- wos:000275537100008
- pmid:19937248
- scopus:77952095796
- pmid:19937248
- ISSN
- 1433-0350
- DOI
- 10.1007/s00381-009-1035-z
- language
- English
- LU publication?
- yes
- id
- 5105d287-8dc5-4794-a479-f42527daa8da (old id 1511562)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19937248?dopt=Abstract
- date added to LUP
- 2016-04-04 07:18:10
- date last changed
- 2022-02-05 22:28:43
@article{5105d287-8dc5-4794-a479-f42527daa8da,
abstract = {{It is of obvious clinical importance to monitor cerebral metabolism-in particular, cerebral energy metabolism and indicators of cellular damage-online at the bedside. The technique of cerebral microdialysis provides the opportunity for continuous monitoring of metabolic changes in the tissue before they are reflected in peripheral blood chemistry or in systemic physiological parameters. The basic idea of microdialysis is to mimic the function of a blood capillary by positioning a thin dialysis tube in the tissue and to be used to analyze the chemical composition of the interstitial fluid. The biochemical variables used during routine monitoring were chosen to cover important aspects of cerebral energy metabolism (glucose, pyruvate and lactate), to indicate excessive interstitial levels of excitatory transmitter substance (glutamate) and to give indications of degradation of cellular membranes (glycerol). Furthermore, pharmokinetic studies can be conducted using microdialysis. This article discusses technical and physiological aspects of microdialysis, and its clinical applications in brain injury.}},
author = {{Nordström, Carl-Henrik}},
issn = {{1433-0350}},
language = {{eng}},
pages = {{465--472}},
publisher = {{Springer}},
series = {{Child's Nervous System}},
title = {{Cerebral energy metabolism and microdialysis in neurocritical care.}},
url = {{http://dx.doi.org/10.1007/s00381-009-1035-z}},
doi = {{10.1007/s00381-009-1035-z}},
volume = {{26}},
year = {{2010}},
}