Prostate Cancer Radiation Therapy and Risk of Thromboembolic Events
Bosco, Cecilia ; Garmo, Hans ; Adolfsson, Jan ; Stattin, Pär ; Holmberg, Lars ; Nilsson, Per LU
; Gunnlaugsson, Adalsteinn
LU
; Widmark, Anders
and Van Hemelrijck, Mieke
(2017)
In International Journal of Radiation Oncology Biology Physics
97(5).
p.1026-1031
- Abstract
Purpose To investigate the risk of thromboembolic disease (TED) after radiation therapy (RT) with curative intent for prostate cancer (PCa). Patients and Methods We identified all men who received RT as curative treatment (n=9410) and grouped according to external beam RT (EBRT) or brachytherapy (BT). By comparing with an age- and county-matched comparison cohort of PCa-free men (n=46,826), we investigated risk of TED after RT using Cox proportional hazard regression models. The model was adjusted for tumor characteristics, demographics, comorbidities, PCa treatments, and known risk factors of TED, such as recent surgery and disease progression. Results Between 2006 and 2013, 6232 men with PCa received EBRT, and 3178 underwent BT. A... (More)
Purpose To investigate the risk of thromboembolic disease (TED) after radiation therapy (RT) with curative intent for prostate cancer (PCa). Patients and Methods We identified all men who received RT as curative treatment (n=9410) and grouped according to external beam RT (EBRT) or brachytherapy (BT). By comparing with an age- and county-matched comparison cohort of PCa-free men (n=46,826), we investigated risk of TED after RT using Cox proportional hazard regression models. The model was adjusted for tumor characteristics, demographics, comorbidities, PCa treatments, and known risk factors of TED, such as recent surgery and disease progression. Results Between 2006 and 2013, 6232 men with PCa received EBRT, and 3178 underwent BT. A statistically significant association was found between EBRT and BT and risk of pulmonary embolism in the crude analysis. However, upon adjusting for known TED risk factors these associations disappeared. No significant associations were found between BT or EBRT and deep venous thrombosis. Conclusion Curative RT for prostate cancer using contemporary methodologies was not associated with an increased risk of TED.
(Less)
- author
- Bosco, Cecilia
; Garmo, Hans
; Adolfsson, Jan
; Stattin, Pär
; Holmberg, Lars
; Nilsson, Per
LU
; Gunnlaugsson, Adalsteinn
LU
; Widmark, Anders
and Van Hemelrijck, Mieke
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Radiation Oncology Biology Physics
- volume
- 97
- issue
- 5
- pages
- 6 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85015272720
- pmid:28332985
- wos:000401128500026
- ISSN
- 0360-3016
- DOI
- 10.1016/j.ijrobp.2017.01.218
- language
- English
- LU publication?
- yes
- id
- 5122464a-3e9d-4f35-9ba8-70af07ed2025
- date added to LUP
- 2017-04-03 10:14:21
- date last changed
- 2025-01-07 10:41:17
@article{5122464a-3e9d-4f35-9ba8-70af07ed2025,
abstract = {{<p>Purpose To investigate the risk of thromboembolic disease (TED) after radiation therapy (RT) with curative intent for prostate cancer (PCa). Patients and Methods We identified all men who received RT as curative treatment (n=9410) and grouped according to external beam RT (EBRT) or brachytherapy (BT). By comparing with an age- and county-matched comparison cohort of PCa-free men (n=46,826), we investigated risk of TED after RT using Cox proportional hazard regression models. The model was adjusted for tumor characteristics, demographics, comorbidities, PCa treatments, and known risk factors of TED, such as recent surgery and disease progression. Results Between 2006 and 2013, 6232 men with PCa received EBRT, and 3178 underwent BT. A statistically significant association was found between EBRT and BT and risk of pulmonary embolism in the crude analysis. However, upon adjusting for known TED risk factors these associations disappeared. No significant associations were found between BT or EBRT and deep venous thrombosis. Conclusion Curative RT for prostate cancer using contemporary methodologies was not associated with an increased risk of TED.</p>}},
author = {{Bosco, Cecilia and Garmo, Hans and Adolfsson, Jan and Stattin, Pär and Holmberg, Lars and Nilsson, Per and Gunnlaugsson, Adalsteinn and Widmark, Anders and Van Hemelrijck, Mieke}},
issn = {{0360-3016}},
language = {{eng}},
number = {{5}},
pages = {{1026--1031}},
publisher = {{Elsevier}},
series = {{International Journal of Radiation Oncology Biology Physics}},
title = {{Prostate Cancer Radiation Therapy and Risk of Thromboembolic Events}},
url = {{http://dx.doi.org/10.1016/j.ijrobp.2017.01.218}},
doi = {{10.1016/j.ijrobp.2017.01.218}},
volume = {{97}},
year = {{2017}},
}