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Prostate Cancer Radiation Therapy and Risk of Thromboembolic Events

Bosco, Cecilia; Garmo, Hans; Adolfsson, Jan; Stattin, Pär; Holmberg, Lars; Nilsson, Per LU ; Gunnlaugsson, Adalsteinn LU ; Widmark, Anders and Van Hemelrijck, Mieke (2017) In International Journal of Radiation Oncology Biology Physics 97(5). p.1026-1031
Abstract

Purpose To investigate the risk of thromboembolic disease (TED) after radiation therapy (RT) with curative intent for prostate cancer (PCa). Patients and Methods We identified all men who received RT as curative treatment (n=9410) and grouped according to external beam RT (EBRT) or brachytherapy (BT). By comparing with an age- and county-matched comparison cohort of PCa-free men (n=46,826), we investigated risk of TED after RT using Cox proportional hazard regression models. The model was adjusted for tumor characteristics, demographics, comorbidities, PCa treatments, and known risk factors of TED, such as recent surgery and disease progression. Results Between 2006 and 2013, 6232 men with PCa received EBRT, and 3178 underwent BT. A... (More)

Purpose To investigate the risk of thromboembolic disease (TED) after radiation therapy (RT) with curative intent for prostate cancer (PCa). Patients and Methods We identified all men who received RT as curative treatment (n=9410) and grouped according to external beam RT (EBRT) or brachytherapy (BT). By comparing with an age- and county-matched comparison cohort of PCa-free men (n=46,826), we investigated risk of TED after RT using Cox proportional hazard regression models. The model was adjusted for tumor characteristics, demographics, comorbidities, PCa treatments, and known risk factors of TED, such as recent surgery and disease progression. Results Between 2006 and 2013, 6232 men with PCa received EBRT, and 3178 underwent BT. A statistically significant association was found between EBRT and BT and risk of pulmonary embolism in the crude analysis. However, upon adjusting for known TED risk factors these associations disappeared. No significant associations were found between BT or EBRT and deep venous thrombosis. Conclusion Curative RT for prostate cancer using contemporary methodologies was not associated with an increased risk of TED.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Radiation Oncology Biology Physics
volume
97
issue
5
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:85015272720
  • wos:000401128500026
ISSN
0360-3016
DOI
10.1016/j.ijrobp.2017.01.218
language
English
LU publication?
yes
id
5122464a-3e9d-4f35-9ba8-70af07ed2025
date added to LUP
2017-04-03 10:14:21
date last changed
2018-03-04 05:00:40
@article{5122464a-3e9d-4f35-9ba8-70af07ed2025,
  abstract     = {<p>Purpose To investigate the risk of thromboembolic disease (TED) after radiation therapy (RT) with curative intent for prostate cancer (PCa). Patients and Methods We identified all men who received RT as curative treatment (n=9410) and grouped according to external beam RT (EBRT) or brachytherapy (BT). By comparing with an age- and county-matched comparison cohort of PCa-free men (n=46,826), we investigated risk of TED after RT using Cox proportional hazard regression models. The model was adjusted for tumor characteristics, demographics, comorbidities, PCa treatments, and known risk factors of TED, such as recent surgery and disease progression. Results Between 2006 and 2013, 6232 men with PCa received EBRT, and 3178 underwent BT. A statistically significant association was found between EBRT and BT and risk of pulmonary embolism in the crude analysis. However, upon adjusting for known TED risk factors these associations disappeared. No significant associations were found between BT or EBRT and deep venous thrombosis. Conclusion Curative RT for prostate cancer using contemporary methodologies was not associated with an increased risk of TED.</p>},
  author       = {Bosco, Cecilia and Garmo, Hans and Adolfsson, Jan and Stattin, Pär and Holmberg, Lars and Nilsson, Per and Gunnlaugsson, Adalsteinn and Widmark, Anders and Van Hemelrijck, Mieke},
  issn         = {0360-3016},
  language     = {eng},
  number       = {5},
  pages        = {1026--1031},
  publisher    = {Elsevier},
  series       = {International Journal of Radiation Oncology Biology Physics},
  title        = {Prostate Cancer Radiation Therapy and Risk of Thromboembolic Events},
  url          = {http://dx.doi.org/10.1016/j.ijrobp.2017.01.218},
  volume       = {97},
  year         = {2017},
}