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Exerkine GPLD1 bridges liver and brain

Plaza-Florido, Abel ; Carrera-Bastos, Pedro LU and Lucia, Alejandro (2026) In Cell Metabolism 38(5). p.841-843
Abstract

A recent study by Bieri et al. shows that exercise elevates hepatic glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1), which cleaves endothelial tissue-nonspecific alkaline phosphatase (TNAP) to rejuvenate cerebrovascular signaling, enhance cognition in aging, and attenuate Alzheimer’s-related pathology. This liver-to-brain enzymatic axis positions hepatokines as potent mediators of exercise-induced neuroprotection, which redefines systemic metabolism as a driver of brain resilience.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cell Metabolism
volume
38
issue
5
pages
3 pages
publisher
Cell Press
external identifiers
  • pmid:42091041
  • scopus:105037597590
ISSN
1550-4131
DOI
10.1016/j.cmet.2026.04.002
language
English
LU publication?
yes
id
512403e3-8e53-4136-92bc-e55b48975aa2
date added to LUP
2026-08-17 08:58:33
date last changed
2026-09-28 11:30:09
@misc{512403e3-8e53-4136-92bc-e55b48975aa2,
  abstract     = {{<p>A recent study by Bieri et al. shows that exercise elevates hepatic glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1), which cleaves endothelial tissue-nonspecific alkaline phosphatase (TNAP) to rejuvenate cerebrovascular signaling, enhance cognition in aging, and attenuate Alzheimer’s-related pathology. This liver-to-brain enzymatic axis positions hepatokines as potent mediators of exercise-induced neuroprotection, which redefines systemic metabolism as a driver of brain resilience.</p>}},
  author       = {{Plaza-Florido, Abel and Carrera-Bastos, Pedro and Lucia, Alejandro}},
  issn         = {{1550-4131}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{841--843}},
  publisher    = {{Cell Press}},
  series       = {{Cell Metabolism}},
  title        = {{Exerkine GPLD1 bridges liver and brain}},
  url          = {{http://dx.doi.org/10.1016/j.cmet.2026.04.002}},
  doi          = {{10.1016/j.cmet.2026.04.002}},
  volume       = {{38}},
  year         = {{2026}},
}