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A prospective study of positron emission tomography for evaluation of neck node response 6 weeks after radiotherapy in patients with head and neck squamous cell carcinoma.

Sjövall, Johanna LU ; Wahlberg, Peter LU ; Almquist, Helen; Kjellén, Elisabeth LU and Brun, Eva LU (2015) In Head and Neck
Abstract
Background: The purpose of this study was to evaluate if a positron emission tomography (PET) scan, 6 weeks post radiotherapy (RT), adequately selects patients in whom a neck node dissection can be omitted. Primary endpoints were isolated neck recurrences and overall survival (OS). Methods: 105 patients, mainly with oropharyngeal human papilloma virus (HPV) positive tumors, with a positive PET scan before treatment, were evaluated regarding the neck response 6 weeks post RT. The PET results determined the management of the neck: observation vs. neck dissection. Results: Median follow-up was 25 months. Positive predictive value (PPV) and negative predictive value (NPV) were 56% and 94%, respectively. Four isolated neck recurrences occurred.... (More)
Background: The purpose of this study was to evaluate if a positron emission tomography (PET) scan, 6 weeks post radiotherapy (RT), adequately selects patients in whom a neck node dissection can be omitted. Primary endpoints were isolated neck recurrences and overall survival (OS). Methods: 105 patients, mainly with oropharyngeal human papilloma virus (HPV) positive tumors, with a positive PET scan before treatment, were evaluated regarding the neck response 6 weeks post RT. The PET results determined the management of the neck: observation vs. neck dissection. Results: Median follow-up was 25 months. Positive predictive value (PPV) and negative predictive value (NPV) were 56% and 94%, respectively. Four isolated neck recurrences occurred. The 2 year OS rate was 86.3%. Conclusion: PET scans performed 6 weeks after RT have a high NPV and can obviate neck dissections but the PPV is insufficient. A later scheduled scan is recommended. This article is protected by copyright. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Head and Neck
publisher
John Wiley & Sons
external identifiers
  • pmid:25716933
  • scopus:84938880630
ISSN
1043-3074
DOI
10.1002/hed.24021
language
English
LU publication?
yes
id
1e674bce-7954-4555-87fd-d7d82e59bc7c (old id 5142660)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25716933?dopt=Abstract
date added to LUP
2015-03-11 17:00:33
date last changed
2017-10-08 04:28:50
@article{1e674bce-7954-4555-87fd-d7d82e59bc7c,
  abstract     = {Background: The purpose of this study was to evaluate if a positron emission tomography (PET) scan, 6 weeks post radiotherapy (RT), adequately selects patients in whom a neck node dissection can be omitted. Primary endpoints were isolated neck recurrences and overall survival (OS). Methods: 105 patients, mainly with oropharyngeal human papilloma virus (HPV) positive tumors, with a positive PET scan before treatment, were evaluated regarding the neck response 6 weeks post RT. The PET results determined the management of the neck: observation vs. neck dissection. Results: Median follow-up was 25 months. Positive predictive value (PPV) and negative predictive value (NPV) were 56% and 94%, respectively. Four isolated neck recurrences occurred. The 2 year OS rate was 86.3%. Conclusion: PET scans performed 6 weeks after RT have a high NPV and can obviate neck dissections but the PPV is insufficient. A later scheduled scan is recommended. This article is protected by copyright. All rights reserved.},
  author       = {Sjövall, Johanna and Wahlberg, Peter and Almquist, Helen and Kjellén, Elisabeth and Brun, Eva},
  issn         = {1043-3074},
  language     = {eng},
  month        = {02},
  publisher    = {John Wiley & Sons},
  series       = {Head and Neck},
  title        = {A prospective study of positron emission tomography for evaluation of neck node response 6 weeks after radiotherapy in patients with head and neck squamous cell carcinoma.},
  url          = {http://dx.doi.org/10.1002/hed.24021},
  year         = {2015},
}