A prospective study of positron emission tomography for evaluation of neck node response 6 weeks after radiotherapy in patients with head and neck squamous cell carcinoma.
(2015) In Head and Neck- Abstract
- Background: The purpose of this study was to evaluate if a positron emission tomography (PET) scan, 6 weeks post radiotherapy (RT), adequately selects patients in whom a neck node dissection can be omitted. Primary endpoints were isolated neck recurrences and overall survival (OS). Methods: 105 patients, mainly with oropharyngeal human papilloma virus (HPV) positive tumors, with a positive PET scan before treatment, were evaluated regarding the neck response 6 weeks post RT. The PET results determined the management of the neck: observation vs. neck dissection. Results: Median follow-up was 25 months. Positive predictive value (PPV) and negative predictive value (NPV) were 56% and 94%, respectively. Four isolated neck recurrences occurred.... (More)
- Background: The purpose of this study was to evaluate if a positron emission tomography (PET) scan, 6 weeks post radiotherapy (RT), adequately selects patients in whom a neck node dissection can be omitted. Primary endpoints were isolated neck recurrences and overall survival (OS). Methods: 105 patients, mainly with oropharyngeal human papilloma virus (HPV) positive tumors, with a positive PET scan before treatment, were evaluated regarding the neck response 6 weeks post RT. The PET results determined the management of the neck: observation vs. neck dissection. Results: Median follow-up was 25 months. Positive predictive value (PPV) and negative predictive value (NPV) were 56% and 94%, respectively. Four isolated neck recurrences occurred. The 2 year OS rate was 86.3%. Conclusion: PET scans performed 6 weeks after RT have a high NPV and can obviate neck dissections but the PPV is insufficient. A later scheduled scan is recommended. This article is protected by copyright. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5142660
- author
- Sjövall, Johanna LU ; Wahlberg, Peter LU ; Almquist, Helen ; Kjellén, Elisabeth LU and Brun, Eva LU
- organization
- publishing date
- 2015-02-26
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Head and Neck
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:25716933
- scopus:84938880630
- pmid:25716933
- wos:000375116400050
- ISSN
- 1043-3074
- DOI
- 10.1002/hed.24021
- language
- English
- LU publication?
- yes
- id
- 1e674bce-7954-4555-87fd-d7d82e59bc7c (old id 5142660)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25716933?dopt=Abstract
- date added to LUP
- 2016-04-04 07:42:44
- date last changed
- 2022-03-15 07:19:43
@article{1e674bce-7954-4555-87fd-d7d82e59bc7c,
abstract = {{Background: The purpose of this study was to evaluate if a positron emission tomography (PET) scan, 6 weeks post radiotherapy (RT), adequately selects patients in whom a neck node dissection can be omitted. Primary endpoints were isolated neck recurrences and overall survival (OS). Methods: 105 patients, mainly with oropharyngeal human papilloma virus (HPV) positive tumors, with a positive PET scan before treatment, were evaluated regarding the neck response 6 weeks post RT. The PET results determined the management of the neck: observation vs. neck dissection. Results: Median follow-up was 25 months. Positive predictive value (PPV) and negative predictive value (NPV) were 56% and 94%, respectively. Four isolated neck recurrences occurred. The 2 year OS rate was 86.3%. Conclusion: PET scans performed 6 weeks after RT have a high NPV and can obviate neck dissections but the PPV is insufficient. A later scheduled scan is recommended. This article is protected by copyright. All rights reserved.}},
author = {{Sjövall, Johanna and Wahlberg, Peter and Almquist, Helen and Kjellén, Elisabeth and Brun, Eva}},
issn = {{1043-3074}},
language = {{eng}},
month = {{02}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Head and Neck}},
title = {{A prospective study of positron emission tomography for evaluation of neck node response 6 weeks after radiotherapy in patients with head and neck squamous cell carcinoma.}},
url = {{http://dx.doi.org/10.1002/hed.24021}},
doi = {{10.1002/hed.24021}},
year = {{2015}},
}