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TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.

Chittani, Martina; Zaninello, Roberta; Lanzani, Chiara; Frau, Francesca; Ortu, Maria F; Salvi, Erika; Fresu, Giovanni; Citterio, Lorena; Braga, Daniele and Piras, Daniela A, et al. (2015) In Journal of Hypertension 33(6). p.1301-1309
Abstract
Thiazide diuretics have been recommended as a first-line antihypertensive treatment, although the choice of 'the right drug in the individual essential hypertensive patient' remains still empirical. Essential hypertension is a complex, polygenic disease derived from the interaction of patient's genetic background with the environment. Pharmacogenomics could be a useful tool to pinpoint gene variants involved in antihypertensive drug response, thus optimizing therapeutic advantages and minimizing side effects.
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Contribution to journal
publication status
published
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in
Journal of Hypertension
volume
33
issue
6
pages
1301 - 1309
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:25695618
  • wos:000353819700026
  • scopus:84929458153
ISSN
1473-5598
DOI
10.1097/HJH.0000000000000541
language
English
LU publication?
yes
id
113f79ce-557a-44d7-afed-1dfe59fba0e9 (old id 5143308)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25695618?dopt=Abstract
date added to LUP
2015-03-08 20:03:35
date last changed
2017-11-19 03:01:35
@article{113f79ce-557a-44d7-afed-1dfe59fba0e9,
  abstract     = {Thiazide diuretics have been recommended as a first-line antihypertensive treatment, although the choice of 'the right drug in the individual essential hypertensive patient' remains still empirical. Essential hypertension is a complex, polygenic disease derived from the interaction of patient's genetic background with the environment. Pharmacogenomics could be a useful tool to pinpoint gene variants involved in antihypertensive drug response, thus optimizing therapeutic advantages and minimizing side effects.},
  author       = {Chittani, Martina and Zaninello, Roberta and Lanzani, Chiara and Frau, Francesca and Ortu, Maria F and Salvi, Erika and Fresu, Giovanni and Citterio, Lorena and Braga, Daniele and Piras, Daniela A and Carpini, Simona Delli and Velayutham, Dinesh and Simonini, Marco and Argiolas, Giuseppe and Pozzoli, Simona and Troffa, Chiara and Glorioso, Valeria and Kontula, Kimmo K and Hiltunen, Timo P and Donner, Kati M and Turner, Stephen T and Boerwinkle, Eric and Chapman, Arlene B and Padmanabhan, Sandosh and Dominiczak, Anna F and Melander, Olle and Johnson, Julie A and Cooper-Dehoff, Rhonda M and Gong, Yan and Rivera, Natalia V and Condorelli, Gianluigi and Trimarco, Bruno and Manunta, Paolo and Cusi, Daniele and Glorioso, Nicola and Barlassina, Cristina},
  issn         = {1473-5598},
  language     = {eng},
  number       = {6},
  pages        = {1301--1309},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.},
  url          = {http://dx.doi.org/10.1097/HJH.0000000000000541},
  volume       = {33},
  year         = {2015},
}