The Inflammatory Marker suPAR After Cardiac Arrest.
(2015) In Therapeutic hypothermia and temperature management 5(2). p.89-94- Abstract
- Background: Soluble urokinase plasminogen activator receptor (suPAR) is released in response to inflammatory stimuli, and plasma levels are associated with long-term outcomes. The ischemia/reperfusion injury caused by cardiac arrest (CA) and resuscitation triggers an inflammatory response. This pilot study aimed at investigating suPAR levels in relation to outcome after CA and mild induced hypothermia. Methods: suPAR levels were measured at 6, 36, and 72 hours in patients treated with hypothermia after CA. suPAR levels were analyzed in relation to survival after 6 months. Receiver operating characteristic curve (ROC)-analyses were performed, and area under the curve (AUC) was calculated. Time to return of spontaneous circulation (ROSC) was... (More)
- Background: Soluble urokinase plasminogen activator receptor (suPAR) is released in response to inflammatory stimuli, and plasma levels are associated with long-term outcomes. The ischemia/reperfusion injury caused by cardiac arrest (CA) and resuscitation triggers an inflammatory response. This pilot study aimed at investigating suPAR levels in relation to outcome after CA and mild induced hypothermia. Methods: suPAR levels were measured at 6, 36, and 72 hours in patients treated with hypothermia after CA. suPAR levels were analyzed in relation to survival after 6 months. Receiver operating characteristic curve (ROC)-analyses were performed, and area under the curve (AUC) was calculated. Time to return of spontaneous circulation (ROSC) was correlated to suPAR levels. Results: Fifty-five patients (40 male, median 65 years) were included, and 33 (60%) were alive after 6 months. The suPAR levels were significantly higher in nonsurviving patients compared with survivors at 6 and 36 hours (p=0.006 and 0.034 respectively), but not at 72 hours. The suPAR levels increased from 6 to 72 hours (p<0.0001). Time to ROSC correlated positively with suPAR levels at 6 hours (p=0.003) but not at 36 and 72 hours. ROC analysis shoved an AUC of 0.76 at 6 hours. In the subgroup of CA of cardiac cause, the AUC was 0.84. Conclusion: suPAR levels at 6 and 36 hours after CA were significantly higher in nonsurviving patients compared with survivors; however, the overlap in suPAR levels between the outcome groups was substantial, reducing the prognostic value. There was a significant increase in suPAR levels during the first 72 hours after CA. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5143347
- author
- Rundgren, Malin LU ; Lyngbaek, Stig ; Fisker, Helle and Friberg, Hans LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Therapeutic hypothermia and temperature management
- volume
- 5
- issue
- 2
- pages
- 89 - 94
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- pmid:25695339
- wos:000368519800007
- scopus:84938485281
- pmid:25695339
- ISSN
- 2153-7933
- DOI
- 10.1089/ther.2014.0027
- language
- English
- LU publication?
- yes
- id
- ba3d9aa2-af38-42e5-b44f-cbc191ce9078 (old id 5143347)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25695339?dopt=Abstract
- date added to LUP
- 2016-04-01 10:11:02
- date last changed
- 2022-04-04 03:14:18
@article{ba3d9aa2-af38-42e5-b44f-cbc191ce9078, abstract = {{Background: Soluble urokinase plasminogen activator receptor (suPAR) is released in response to inflammatory stimuli, and plasma levels are associated with long-term outcomes. The ischemia/reperfusion injury caused by cardiac arrest (CA) and resuscitation triggers an inflammatory response. This pilot study aimed at investigating suPAR levels in relation to outcome after CA and mild induced hypothermia. Methods: suPAR levels were measured at 6, 36, and 72 hours in patients treated with hypothermia after CA. suPAR levels were analyzed in relation to survival after 6 months. Receiver operating characteristic curve (ROC)-analyses were performed, and area under the curve (AUC) was calculated. Time to return of spontaneous circulation (ROSC) was correlated to suPAR levels. Results: Fifty-five patients (40 male, median 65 years) were included, and 33 (60%) were alive after 6 months. The suPAR levels were significantly higher in nonsurviving patients compared with survivors at 6 and 36 hours (p=0.006 and 0.034 respectively), but not at 72 hours. The suPAR levels increased from 6 to 72 hours (p<0.0001). Time to ROSC correlated positively with suPAR levels at 6 hours (p=0.003) but not at 36 and 72 hours. ROC analysis shoved an AUC of 0.76 at 6 hours. In the subgroup of CA of cardiac cause, the AUC was 0.84. Conclusion: suPAR levels at 6 and 36 hours after CA were significantly higher in nonsurviving patients compared with survivors; however, the overlap in suPAR levels between the outcome groups was substantial, reducing the prognostic value. There was a significant increase in suPAR levels during the first 72 hours after CA.}}, author = {{Rundgren, Malin and Lyngbaek, Stig and Fisker, Helle and Friberg, Hans}}, issn = {{2153-7933}}, language = {{eng}}, number = {{2}}, pages = {{89--94}}, publisher = {{Mary Ann Liebert, Inc.}}, series = {{Therapeutic hypothermia and temperature management}}, title = {{The Inflammatory Marker suPAR After Cardiac Arrest.}}, url = {{http://dx.doi.org/10.1089/ther.2014.0027}}, doi = {{10.1089/ther.2014.0027}}, volume = {{5}}, year = {{2015}}, }