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Spatial navigation measured by the Floor Maze Test in patients with subjective cognitive impairment, mild cognitive impairment, and mild Alzheimer's disease.

Tangen, Gro Gujord; Engedal, Knut; Bergland, Astrid; Moger, Tron Anders; Hansson, Oskar LU and Mengshoel, Anne Marit (2015) In International Psychogeriatrics 27(8). p.1401-1409
Abstract
ABSTRACT Background: Impaired spatial navigation is an early sign of Alzheimer's disease (AD), but this can be difficult to assess in clinical practice. We examined how the performance on the Floor Maze Test (FMT), which combines navigation with walking, differed between patients with subjective cognitive impairment (SCI), mild cognitive impairment (MCI), and mild AD. We also explored if there was a significant relationship between the FMT and the cognitive tests or sociodemographic factors. Methods: The study included 128 patients from a memory clinic classified as having SCI (n = 19), MCI (n = 20), and mild AD (n = 89). Spatial navigation was assessed by having the patients walk through the FMT, a two-dimensional maze. Both timed... (More)
ABSTRACT Background: Impaired spatial navigation is an early sign of Alzheimer's disease (AD), but this can be difficult to assess in clinical practice. We examined how the performance on the Floor Maze Test (FMT), which combines navigation with walking, differed between patients with subjective cognitive impairment (SCI), mild cognitive impairment (MCI), and mild AD. We also explored if there was a significant relationship between the FMT and the cognitive tests or sociodemographic factors. Methods: The study included 128 patients from a memory clinic classified as having SCI (n = 19), MCI (n = 20), and mild AD (n = 89). Spatial navigation was assessed by having the patients walk through the FMT, a two-dimensional maze. Both timed measures and number of errors were recorded. Cognitive function was assessed by the Word List Memory test, the Clock Drawing test, the Trail Making tests (TMT) A and B, and the Mini Mental Status Examination (MMSE). Results: The patients with MCI were slower than those with SCI, while the patients with mild AD more frequently completed the FMT with errors or gave up than the patients with MCI. Performance on the FMT was significantly associated with executive function (measured by TMT-B). Conclusions: The performances on the FMT worsened with increasing severity of cognitive impairment, and the FMT was primarily associated with executive function. The explained variance was relatively low, which may indicate that the standard cognitive test battery does not capture impairments of spatial navigation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Psychogeriatrics
volume
27
issue
8
pages
1401 - 1409
publisher
Cambridge University Press
external identifiers
  • pmid:25644091
  • wos:000361384500015
  • scopus:84936890682
ISSN
1741-203X
DOI
10.1017/S1041610215000022
language
English
LU publication?
yes
id
25b6916a-6fd3-439f-82b8-531708fe5b51 (old id 5145651)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25644091?dopt=Abstract
date added to LUP
2015-03-03 16:41:58
date last changed
2017-09-24 03:12:27
@article{25b6916a-6fd3-439f-82b8-531708fe5b51,
  abstract     = {ABSTRACT Background: Impaired spatial navigation is an early sign of Alzheimer's disease (AD), but this can be difficult to assess in clinical practice. We examined how the performance on the Floor Maze Test (FMT), which combines navigation with walking, differed between patients with subjective cognitive impairment (SCI), mild cognitive impairment (MCI), and mild AD. We also explored if there was a significant relationship between the FMT and the cognitive tests or sociodemographic factors. Methods: The study included 128 patients from a memory clinic classified as having SCI (n = 19), MCI (n = 20), and mild AD (n = 89). Spatial navigation was assessed by having the patients walk through the FMT, a two-dimensional maze. Both timed measures and number of errors were recorded. Cognitive function was assessed by the Word List Memory test, the Clock Drawing test, the Trail Making tests (TMT) A and B, and the Mini Mental Status Examination (MMSE). Results: The patients with MCI were slower than those with SCI, while the patients with mild AD more frequently completed the FMT with errors or gave up than the patients with MCI. Performance on the FMT was significantly associated with executive function (measured by TMT-B). Conclusions: The performances on the FMT worsened with increasing severity of cognitive impairment, and the FMT was primarily associated with executive function. The explained variance was relatively low, which may indicate that the standard cognitive test battery does not capture impairments of spatial navigation.},
  author       = {Tangen, Gro Gujord and Engedal, Knut and Bergland, Astrid and Moger, Tron Anders and Hansson, Oskar and Mengshoel, Anne Marit},
  issn         = {1741-203X},
  language     = {eng},
  number       = {8},
  pages        = {1401--1409},
  publisher    = {Cambridge University Press},
  series       = {International Psychogeriatrics},
  title        = {Spatial navigation measured by the Floor Maze Test in patients with subjective cognitive impairment, mild cognitive impairment, and mild Alzheimer's disease.},
  url          = {http://dx.doi.org/10.1017/S1041610215000022},
  volume       = {27},
  year         = {2015},
}