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Hyaluronan in Non-Surgical and Surgical Periodontal Therapy. A Systematic Review.

Bertl, Kristina; Bruckmann, Corinna; Isberg, Per-Erik LU ; Klinge, Björn; Gotfredsen, Klaus and Stavropoulos, Andreas (2015) In Journal of Clinical Periodontology 42(3). p.236-246
Abstract
AIM: To evaluate the effect of hyaluronan (HY) application as monotherapy or as adjunct to non-surgical and/or surgical periodontal therapy.



METHODS: Literature search was performed according to PRISMA guidelines with the following main eligibility criteria: (a) English or German language; (b) preclinical in-vivo or human controlled trials; (c) effect size of HY evaluated histologically or clinically.



RESULTS: Two preclinical in-vivo studies on surgical treatment and 12 clinical trials on non-surgical and/or surgical treatment were included. Most of the studies were highly heterogeneous, regarding with HY product used and application mode, and of high risk of bias, thus not allowing meta-analysis. The... (More)
AIM: To evaluate the effect of hyaluronan (HY) application as monotherapy or as adjunct to non-surgical and/or surgical periodontal therapy.



METHODS: Literature search was performed according to PRISMA guidelines with the following main eligibility criteria: (a) English or German language; (b) preclinical in-vivo or human controlled trials; (c) effect size of HY evaluated histologically or clinically.



RESULTS: Two preclinical in-vivo studies on surgical treatment and 12 clinical trials on non-surgical and/or surgical treatment were included. Most of the studies were highly heterogeneous, regarding with HY product used and application mode, and of high risk of bias, thus not allowing meta-analysis. The majority of clinical studies described a beneficial, occasionally statistically significant, effect of HY on bleeding on probing (BoP) and pocket depth (PD) reduction (2.28-19.5% and 0.2-0.9mm, respectively), comparing to controls; no adverse effects were reported.



CONCLUSIONS: HY application as adjunct to non-surgical and surgical periodontal treatment seems to have a beneficial, generally moderate, effect on surrogate outcome variables of periodontal inflammation, i.e., BoP and residual PD, and appears to be safe. The large heterogeneity of included studies, does not allow recommendations on the mode of application or effect size of HY as adjunct to non-surgical and surgical periodontal treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
clinical trials, hyaluronan, hyaluronate, hyaluronic acid, periodontitis, systematic review
in
Journal of Clinical Periodontology
volume
42
issue
3
pages
236 - 246
publisher
Wiley-Blackwell
external identifiers
  • pmid:25640222
  • wos:000351303600004
  • scopus:84924624480
ISSN
1600-051X
DOI
10.1111/jcpe.12371
language
English
LU publication?
yes
id
65920b72-5933-45f1-8c72-ca32f07e1cb0 (old id 5145705)
date added to LUP
2015-03-06 13:27:22
date last changed
2017-11-05 03:17:08
@article{65920b72-5933-45f1-8c72-ca32f07e1cb0,
  abstract     = {AIM: To evaluate the effect of hyaluronan (HY) application as monotherapy or as adjunct to non-surgical and/or surgical periodontal therapy.<br/><br>
<br/><br>
METHODS: Literature search was performed according to PRISMA guidelines with the following main eligibility criteria: (a) English or German language; (b) preclinical in-vivo or human controlled trials; (c) effect size of HY evaluated histologically or clinically.<br/><br>
<br/><br>
RESULTS: Two preclinical in-vivo studies on surgical treatment and 12 clinical trials on non-surgical and/or surgical treatment were included. Most of the studies were highly heterogeneous, regarding with HY product used and application mode, and of high risk of bias, thus not allowing meta-analysis. The majority of clinical studies described a beneficial, occasionally statistically significant, effect of HY on bleeding on probing (BoP) and pocket depth (PD) reduction (2.28-19.5% and 0.2-0.9mm, respectively), comparing to controls; no adverse effects were reported.<br/><br>
<br/><br>
CONCLUSIONS: HY application as adjunct to non-surgical and surgical periodontal treatment seems to have a beneficial, generally moderate, effect on surrogate outcome variables of periodontal inflammation, i.e., BoP and residual PD, and appears to be safe. The large heterogeneity of included studies, does not allow recommendations on the mode of application or effect size of HY as adjunct to non-surgical and surgical periodontal treatment.},
  author       = {Bertl, Kristina and Bruckmann, Corinna and Isberg, Per-Erik and Klinge, Björn and Gotfredsen, Klaus and Stavropoulos, Andreas},
  issn         = {1600-051X},
  keyword      = {clinical trials,hyaluronan,hyaluronate,hyaluronic acid,periodontitis,systematic review},
  language     = {eng},
  number       = {3},
  pages        = {236--246},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Clinical Periodontology},
  title        = {Hyaluronan in Non-Surgical and Surgical Periodontal Therapy. A Systematic Review.},
  url          = {http://dx.doi.org/10.1111/jcpe.12371},
  volume       = {42},
  year         = {2015},
}