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Cryogels for Biotechnological Applications

Mattiasson, Bo LU (2014) In Advances in Polymer Science 263. p.245-281
Abstract
Cryogels are formed in a semifrozen state when the solvent is frozen, but solutes are still soluble. The ice crystals are porogens and, upon thawing the system, pores appear where the frozen solvent was found earlier. Such gels have large pores, are elastic, and offer interesting opportunities in biotechnology. Cryogels with their large pores can meet demands that traditional chromatographic media cannot. This also opens up opportunities for the separation of cells because upon passage through the gel cells may interact with specific groups on the pore walls, thereby becoming retarded and/or captured. A range of applications have been studied: isolation of microbial cells, capturing of cancer cells, and use of cryogels as matrices for... (More)
Cryogels are formed in a semifrozen state when the solvent is frozen, but solutes are still soluble. The ice crystals are porogens and, upon thawing the system, pores appear where the frozen solvent was found earlier. Such gels have large pores, are elastic, and offer interesting opportunities in biotechnology. Cryogels with their large pores can meet demands that traditional chromatographic media cannot. This also opens up opportunities for the separation of cells because upon passage through the gel cells may interact with specific groups on the pore walls, thereby becoming retarded and/or captured. A range of applications have been studied: isolation of microbial cells, capturing of cancer cells, and use of cryogels as matrices for immobilized cell reactors. Furthermore, the robustness of the gels allows new applications, for example in environmental separation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cell chromatography, Immobilized cells, Molecular imprinting, Cell, bioreactors, Composite cryogels
in
Advances in Polymer Science
volume
263
pages
245 - 281
publisher
Springer
external identifiers
  • wos:000348834500008
  • scopus:84927518994
ISSN
1436-5030
DOI
10.1007/978-3-319-05846-7_7
language
English
LU publication?
yes
id
13256013-9670-48d4-82ff-033fa38c56ed (old id 5172921)
date added to LUP
2015-03-25 11:12:14
date last changed
2017-09-03 03:33:35
@article{13256013-9670-48d4-82ff-033fa38c56ed,
  abstract     = {Cryogels are formed in a semifrozen state when the solvent is frozen, but solutes are still soluble. The ice crystals are porogens and, upon thawing the system, pores appear where the frozen solvent was found earlier. Such gels have large pores, are elastic, and offer interesting opportunities in biotechnology. Cryogels with their large pores can meet demands that traditional chromatographic media cannot. This also opens up opportunities for the separation of cells because upon passage through the gel cells may interact with specific groups on the pore walls, thereby becoming retarded and/or captured. A range of applications have been studied: isolation of microbial cells, capturing of cancer cells, and use of cryogels as matrices for immobilized cell reactors. Furthermore, the robustness of the gels allows new applications, for example in environmental separation.},
  author       = {Mattiasson, Bo},
  issn         = {1436-5030},
  keyword      = {Cell chromatography,Immobilized cells,Molecular imprinting,Cell,bioreactors,Composite cryogels},
  language     = {eng},
  pages        = {245--281},
  publisher    = {Springer},
  series       = {Advances in Polymer Science},
  title        = {Cryogels for Biotechnological Applications},
  url          = {http://dx.doi.org/10.1007/978-3-319-05846-7_7},
  volume       = {263},
  year         = {2014},
}