Advanced

Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology

Ranta, Susanna; Tuckuviene, Ruta; Makipernaa, Anne; Albertsen, Birgitte K.; Frisk, Tony; Tedgård, Ulf LU ; Jonsson, Olafur G.; Pruunsild, Kaie; Gretenkort, Nadine LU and Gunnes, Maria Winther, et al. (2015) In British Journal of Haematology 168(4). p.547-552
Abstract
We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebral sinovenous thrombosis, acute leukaemia, paediatric
in
British Journal of Haematology
volume
168
issue
4
pages
547 - 552
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000349157200012
  • scopus:84923108459
ISSN
0007-1048
DOI
10.1111/bjh.13162
language
English
LU publication?
yes
id
90769fe6-c651-42d0-aa6d-dcb9a14527c8 (old id 5175940)
date added to LUP
2015-04-01 07:37:48
date last changed
2017-11-19 03:16:34
@article{90769fe6-c651-42d0-aa6d-dcb9a14527c8,
  abstract     = {We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.},
  author       = {Ranta, Susanna and Tuckuviene, Ruta and Makipernaa, Anne and Albertsen, Birgitte K. and Frisk, Tony and Tedgård, Ulf and Jonsson, Olafur G. and Pruunsild, Kaie and Gretenkort, Nadine and Gunnes, Maria Winther and Trakymiene, Sonata Saulyte and Frandsen, Thomas and Heyman, Mats and Ruud, Ellen and Helgestad, Jon},
  issn         = {0007-1048},
  keyword      = {cerebral sinovenous thrombosis,acute leukaemia,paediatric},
  language     = {eng},
  number       = {4},
  pages        = {547--552},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {British Journal of Haematology},
  title        = {Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology},
  url          = {http://dx.doi.org/10.1111/bjh.13162},
  volume       = {168},
  year         = {2015},
}