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The effect of sympathetic stimulation on proximal brachial artery mechanics in humans - differential behaviour within the length of the brachial artery?

Bjarnegard, N ; Rydén Ahlgren, Åsa LU ; Sonesson, Björn LU and Lanne, T (2004) In Acta Physiologica Scandinavica 182(1). p.21-27
Abstract
Aims: The mechanical properties of arteries play a major role in the regulation of blood pressure and cardiac performance. The effect of sympathetic stimulation on the mechanical properties of the proximal brachial artery was analysed in 18 healthy volunteers, nine young (25 +/- 2 years) and nine elderly (69 +/- 2 years). Methods: A non-invasive ultrasonic echo-tracking system for measurement of systolic/diastolic variation of the proximal brachial artery diameter in combination with intra-arterial pressure measurements was used to determine wall mechanics. The pressure-diameter (P-D) relationship, distensibility coefficient (DC), compliance coefficient (CC) and stiffness(beta) were obtained at rest and during sympathetic stimulation... (More)
Aims: The mechanical properties of arteries play a major role in the regulation of blood pressure and cardiac performance. The effect of sympathetic stimulation on the mechanical properties of the proximal brachial artery was analysed in 18 healthy volunteers, nine young (25 +/- 2 years) and nine elderly (69 +/- 2 years). Methods: A non-invasive ultrasonic echo-tracking system for measurement of systolic/diastolic variation of the proximal brachial artery diameter in combination with intra-arterial pressure measurements was used to determine wall mechanics. The pressure-diameter (P-D) relationship, distensibility coefficient (DC), compliance coefficient (CC) and stiffness(beta) were obtained at rest and during sympathetic stimulation induced by lower body negative pressure (LBNP). Results: The peripheral vascular resistance increased by 100 and 72%, respectively in the young and elderly during LBNP (P < 0.001). Simultaneously, the mechanical properties of the proximal brachial artery remained unaltered, as estimated from both P-D relationship and stiffness in young (beta-index rest: 5.2 +/- 0.9, LBNP: 5.5 +/- 1.3, NS) as well as elderly (beta-index rest: 13.6 +/- 4.6, LBNP: 16.1 +/- 4.7, NS). Conclusions: LBNP-induced sympathetic activation does not change proximal brachial artery mechanics, in contrast to earlier reports on the muscular distal brachial artery. This may imply that the transition between elastic and muscular artery behaviour is within the length of the brachial artery, where the site of transition from elastic to muscular wall structure needs to be specified in future studies. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ageing, brachial artery, distensibility, lower body negative pressure, sympathetic stimulation, stiffness
in
Acta Physiologica Scandinavica
volume
182
issue
1
pages
21 - 27
publisher
Wiley-Blackwell
external identifiers
  • wos:000223537600003
  • pmid:15329053
  • scopus:4544252770
  • pmid:15329053
ISSN
0001-6772
DOI
10.1111/j.1365-201X.2004.01336.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery (013242200), Clinical Physiology (013242300), Emergency medicine/Medicine/Surgery (013240200), Clinical Physiology and Nuclear Medicine Unit (013242320)
id
51a77295-ae78-4ad7-a4c9-d04b700b3287 (old id 898553)
date added to LUP
2016-04-01 16:39:52
date last changed
2020-01-12 19:35:34
@article{51a77295-ae78-4ad7-a4c9-d04b700b3287,
  abstract     = {Aims: The mechanical properties of arteries play a major role in the regulation of blood pressure and cardiac performance. The effect of sympathetic stimulation on the mechanical properties of the proximal brachial artery was analysed in 18 healthy volunteers, nine young (25 +/- 2 years) and nine elderly (69 +/- 2 years). Methods: A non-invasive ultrasonic echo-tracking system for measurement of systolic/diastolic variation of the proximal brachial artery diameter in combination with intra-arterial pressure measurements was used to determine wall mechanics. The pressure-diameter (P-D) relationship, distensibility coefficient (DC), compliance coefficient (CC) and stiffness(beta) were obtained at rest and during sympathetic stimulation induced by lower body negative pressure (LBNP). Results: The peripheral vascular resistance increased by 100 and 72%, respectively in the young and elderly during LBNP (P &lt; 0.001). Simultaneously, the mechanical properties of the proximal brachial artery remained unaltered, as estimated from both P-D relationship and stiffness in young (beta-index rest: 5.2 +/- 0.9, LBNP: 5.5 +/- 1.3, NS) as well as elderly (beta-index rest: 13.6 +/- 4.6, LBNP: 16.1 +/- 4.7, NS). Conclusions: LBNP-induced sympathetic activation does not change proximal brachial artery mechanics, in contrast to earlier reports on the muscular distal brachial artery. This may imply that the transition between elastic and muscular artery behaviour is within the length of the brachial artery, where the site of transition from elastic to muscular wall structure needs to be specified in future studies.},
  author       = {Bjarnegard, N and Rydén Ahlgren, Åsa and Sonesson, Björn and Lanne, T},
  issn         = {0001-6772},
  language     = {eng},
  number       = {1},
  pages        = {21--27},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica Scandinavica},
  title        = {The effect of sympathetic stimulation on proximal brachial artery mechanics in humans - differential behaviour within the length of the brachial artery?},
  url          = {http://dx.doi.org/10.1111/j.1365-201X.2004.01336.x},
  doi          = {10.1111/j.1365-201X.2004.01336.x},
  volume       = {182},
  year         = {2004},
}