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Noninvasive monitoring of gas in the lungs and intestines of newborn infants using diode lasers: feasibility study.

Lundin, Patrik ; Krite Svanberg, Emilie LU ; Cocola, Lorenzo ; Xu, Märta Lewander ; Somesfalean, Gabriel ; Andersson-Engels, Stefan ; Jahr, John LU ; Fellman, Vineta LU ; Svanberg, Katarina LU and Svanberg, Sune (2013) In Journal of Biomedical Optics 18(12).
Abstract
ABSTRACT. Preterm newborn infants have a high morbidity rate. The most frequently affected organs where free gas is involved are the lungs and intestines. In respiratory distress syndrome, both hyperexpanded and atelectatic (collapsed) areas occur, and in necrotizing enterocolitis, intramural gas may appear in the intestine. Today, these conditions are diagnosed with x-ray radiography. A bed-side, rapid, nonintrusive, and gas-specific technique for in vivo gas sensing would improve diagnosis. We report the use of noninvasive laser spectroscopy, for the first time, to assess gas content in the lungs and intestines of three full-term infants. Water vapor and oxygen were studied with two low-power diode lasers, illuminating the skin and... (More)
ABSTRACT. Preterm newborn infants have a high morbidity rate. The most frequently affected organs where free gas is involved are the lungs and intestines. In respiratory distress syndrome, both hyperexpanded and atelectatic (collapsed) areas occur, and in necrotizing enterocolitis, intramural gas may appear in the intestine. Today, these conditions are diagnosed with x-ray radiography. A bed-side, rapid, nonintrusive, and gas-specific technique for in vivo gas sensing would improve diagnosis. We report the use of noninvasive laser spectroscopy, for the first time, to assess gas content in the lungs and intestines of three full-term infants. Water vapor and oxygen were studied with two low-power diode lasers, illuminating the skin and detecting light a few centimeters away. Water vapor was easily detected in the intestines and was also observed in the lungs. The relatively thick chest walls of the infants prevented detection of the weaker oxygen signal in this study. However, results from a previous phantom study, together with scaling of the results presented here to the typical chest-wall thickness of preterm infants, suggest that oxygen also should be detectable in their lungs. (Less)
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organization
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Contribution to journal
publication status
published
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in
Journal of Biomedical Optics
volume
18
issue
12
article number
127005
publisher
Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society
external identifiers
  • pmid:24362929
  • wos:000331706500046
  • scopus:84890927050
  • pmid:24362929
ISSN
1083-3668
DOI
10.1117/1.JBO.18.12.127005
language
English
LU publication?
yes
id
51b5efee-9a74-47e1-a2cd-8f95e3664797 (old id 4223147)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24362929?dopt=Abstract
date added to LUP
2016-04-01 10:15:18
date last changed
2020-01-05 05:28:48
@article{51b5efee-9a74-47e1-a2cd-8f95e3664797,
  abstract     = {ABSTRACT. Preterm newborn infants have a high morbidity rate. The most frequently affected organs where free gas is involved are the lungs and intestines. In respiratory distress syndrome, both hyperexpanded and atelectatic (collapsed) areas occur, and in necrotizing enterocolitis, intramural gas may appear in the intestine. Today, these conditions are diagnosed with x-ray radiography. A bed-side, rapid, nonintrusive, and gas-specific technique for in vivo gas sensing would improve diagnosis. We report the use of noninvasive laser spectroscopy, for the first time, to assess gas content in the lungs and intestines of three full-term infants. Water vapor and oxygen were studied with two low-power diode lasers, illuminating the skin and detecting light a few centimeters away. Water vapor was easily detected in the intestines and was also observed in the lungs. The relatively thick chest walls of the infants prevented detection of the weaker oxygen signal in this study. However, results from a previous phantom study, together with scaling of the results presented here to the typical chest-wall thickness of preterm infants, suggest that oxygen also should be detectable in their lungs.},
  author       = {Lundin, Patrik and Krite Svanberg, Emilie and Cocola, Lorenzo and Xu, Märta Lewander and Somesfalean, Gabriel and Andersson-Engels, Stefan and Jahr, John and Fellman, Vineta and Svanberg, Katarina and Svanberg, Sune},
  issn         = {1083-3668},
  language     = {eng},
  number       = {12},
  publisher    = {Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society},
  series       = {Journal of Biomedical Optics},
  title        = {Noninvasive monitoring of gas in the lungs and intestines of newborn infants using diode lasers: feasibility study.},
  url          = {http://dx.doi.org/10.1117/1.JBO.18.12.127005},
  doi          = {10.1117/1.JBO.18.12.127005},
  volume       = {18},
  year         = {2013},
}