Changes in aortic wall stiffness in men with alpha 1-antitrypsin deficiency
Rydén Ahlgren, Åsa LU
; Piitulainen, Eeva
LU
; Sonesson, Björn
LU
and Länne, T
(1997)
In European Journal of Vascular and Endovascular Surgery
14(4).
p.252-257
- Abstract
- Objectives:
To examine the diameter and distensibility of the abdominal aorta in patients with severe α1-antitrypsin deficiency, and to compare the results with those of normal subjects.
Material and methods:
Abdominal aortic diameter and stiffness (β) was measured using echo-tracking sonography in 19 men (mean age 50, range 25–79) and 17 women (mean age 46, range 26–62) with severe α2-antitrypsin deficiency. The results were compared with those of healthy individuals of corresponding age and gender.
Results:
There was no significant difference in the abdominal aortic diameter between controls and patients with α1-antitrypsin deficiency when corrected for age, sex... (More) - Objectives:
To examine the diameter and distensibility of the abdominal aorta in patients with severe α1-antitrypsin deficiency, and to compare the results with those of normal subjects.
Material and methods:
Abdominal aortic diameter and stiffness (β) was measured using echo-tracking sonography in 19 men (mean age 50, range 25–79) and 17 women (mean age 46, range 26–62) with severe α2-antitrypsin deficiency. The results were compared with those of healthy individuals of corresponding age and gender.
Results:
There was no significant difference in the abdominal aortic diameter between controls and patients with α1-antitrypsin deficiency when corrected for age, sex and body surface area (men p = 0.20, women p = 0.10). Men with α1-antitrypsin deficiency showed significantly lower stiffness in the abdominal aorta compared to controls (p = 0.025), whereas women did not (p = 0.17).
Conclusions:
No significant difference in abdominal aortic diameter could be detected in patients with α1-antitrypsin deficiency compared with controls. However, aortic distensibility in men with α1-antitrypsin deficiency is altered. This may reflect early vessel wall abnormality. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1112219
- author
- Rydén Ahlgren, Åsa
LU
; Piitulainen, Eeva
LU
; Sonesson, Björn
LU
and Länne, T
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Ultrasound, Abdominal aortic aneurysms, α1-antitrypsin deficiency, Distensibility
- in
- European Journal of Vascular and Endovascular Surgery
- volume
- 14
- issue
- 4
- pages
- 252 - 257
- publisher
- Elsevier
- external identifiers
-
- pmid:9366788
- scopus:0030831530
- ISSN
- 1532-2165
- DOI
- 10.1016/S1078-5884(97)80236-5
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Respiratory Medicine and Allergology (013230111), Clinical Physiology and Nuclear Medicine Unit (013242320)
- id
- 51fd1165-6d04-4ede-9b00-1d68789ea88a (old id 1112219)
- date added to LUP
- 2016-04-01 16:48:04
- date last changed
- 2023-09-05 01:31:37
@article{51fd1165-6d04-4ede-9b00-1d68789ea88a,
abstract = {{Objectives:<br/><br>
<br/><br>
To examine the diameter and distensibility of the abdominal aorta in patients with severe α1-antitrypsin deficiency, and to compare the results with those of normal subjects.<br/><br>
Material and methods:<br/><br>
<br/><br>
Abdominal aortic diameter and stiffness (β) was measured using echo-tracking sonography in 19 men (mean age 50, range 25–79) and 17 women (mean age 46, range 26–62) with severe α2-antitrypsin deficiency. The results were compared with those of healthy individuals of corresponding age and gender.<br/><br>
Results:<br/><br>
<br/><br>
There was no significant difference in the abdominal aortic diameter between controls and patients with α1-antitrypsin deficiency when corrected for age, sex and body surface area (men p = 0.20, women p = 0.10). Men with α1-antitrypsin deficiency showed significantly lower stiffness in the abdominal aorta compared to controls (p = 0.025), whereas women did not (p = 0.17).<br/><br>
Conclusions:<br/><br>
<br/><br>
No significant difference in abdominal aortic diameter could be detected in patients with α1-antitrypsin deficiency compared with controls. However, aortic distensibility in men with α1-antitrypsin deficiency is altered. This may reflect early vessel wall abnormality.}},
author = {{Rydén Ahlgren, Åsa and Piitulainen, Eeva and Sonesson, Björn and Länne, T}},
issn = {{1532-2165}},
keywords = {{Ultrasound; Abdominal aortic aneurysms; α1-antitrypsin deficiency; Distensibility}},
language = {{eng}},
number = {{4}},
pages = {{252--257}},
publisher = {{Elsevier}},
series = {{European Journal of Vascular and Endovascular Surgery}},
title = {{Changes in aortic wall stiffness in men with alpha 1-antitrypsin deficiency}},
url = {{http://dx.doi.org/10.1016/S1078-5884(97)80236-5}},
doi = {{10.1016/S1078-5884(97)80236-5}},
volume = {{14}},
year = {{1997}},
}