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Association of Chromosome 19 to Lung Cancer Genotypes and Phenotypes

Wang, Xiangdong ; Zhang, Yong ; Nilsson, Carol LU ; Berven, Frode ; Andrén, Per E. ; Carlsohn, Elisabet ; Horvatovich, Peter ; Malm, Johan LU ; Fuentes, Manuel and Végvári, Ákos LU , et al. (2015) In Cancer and Metastasis Reviews 34(2). p.217-226
Abstract
The Chromosome 19 Consortium, a part of the Chromosome-Centric Human Proteome Project (C-HPP, http://​www.​C-HPP.​org), is tasked with the understanding chromosome 19 functions at the gene and protein levels, as well as their roles in lung oncogenesis. Comparative genomic hybridization (CGH) studies revealed chromosome aberration in lung cancer subtypes, including ADC, SCC, LCC, and SCLC. The most common abnormality is 19p loss and 19q gain. Sixty-four aberrant genes identified in previous genomic studies and their encoded protein functions were further validated in the neXtProt database (http://​www.​nextprot.​org/​). Among those, the loss of tumor suppressor genes STK11, MUM1, KISS1R (19p13.3), and BRG1 (19p13.13) is associated with lung... (More)
The Chromosome 19 Consortium, a part of the Chromosome-Centric Human Proteome Project (C-HPP, http://​www.​C-HPP.​org), is tasked with the understanding chromosome 19 functions at the gene and protein levels, as well as their roles in lung oncogenesis. Comparative genomic hybridization (CGH) studies revealed chromosome aberration in lung cancer subtypes, including ADC, SCC, LCC, and SCLC. The most common abnormality is 19p loss and 19q gain. Sixty-four aberrant genes identified in previous genomic studies and their encoded protein functions were further validated in the neXtProt database (http://​www.​nextprot.​org/​). Among those, the loss of tumor suppressor genes STK11, MUM1, KISS1R (19p13.3), and BRG1 (19p13.13) is associated with lung oncogenesis or remote metastasis. Gene aberrations include translocation t(15, 19) (q13, p13.1) fusion oncogene BRD4-NUT, DNA repair genes (ERCC1, ERCC2, XRCC1), TGFβ1 pathway activation genes (TGFB1, LTBP4), Dyrk1B, and potential oncogenesis protector genes such as NFkB pathway inhibition genes (NFKBIB, PPP1R13L) and EGLN2. In conclusion, neXtProt is an effective resource for the validation of gene aberrations identified in genomic studies. It promises to enhance our understanding of lung cancer oncogenesis. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer and Metastasis Reviews
volume
34
issue
2
pages
217 - 226
publisher
Springer
external identifiers
  • wos:000358743300006
  • scopus:84938417469
  • pmid:25982285
ISSN
0167-7659
DOI
10.1007/s10555-015-9556-2
language
English
LU publication?
yes
id
3cf3a03a-f36a-45df-9fa9-8c264c1b3607 (old id 5218942)
date added to LUP
2016-04-01 10:38:27
date last changed
2023-09-14 08:30:33
@article{3cf3a03a-f36a-45df-9fa9-8c264c1b3607,
  abstract     = {{The Chromosome 19 Consortium, a part of the Chromosome-Centric Human Proteome Project (C-HPP, http://​www.​C-HPP.​org), is tasked with the understanding chromosome 19 functions at the gene and protein levels, as well as their roles in lung oncogenesis. Comparative genomic hybridization (CGH) studies revealed chromosome aberration in lung cancer subtypes, including ADC, SCC, LCC, and SCLC. The most common abnormality is 19p loss and 19q gain. Sixty-four aberrant genes identified in previous genomic studies and their encoded protein functions were further validated in the neXtProt database (http://​www.​nextprot.​org/​). Among those, the loss of tumor suppressor genes STK11, MUM1, KISS1R (19p13.3), and BRG1 (19p13.13) is associated with lung oncogenesis or remote metastasis. Gene aberrations include translocation t(15, 19) (q13, p13.1) fusion oncogene BRD4-NUT, DNA repair genes (ERCC1, ERCC2, XRCC1), TGFβ1 pathway activation genes (TGFB1, LTBP4), Dyrk1B, and potential oncogenesis protector genes such as NFkB pathway inhibition genes (NFKBIB, PPP1R13L) and EGLN2. In conclusion, neXtProt is an effective resource for the validation of gene aberrations identified in genomic studies. It promises to enhance our understanding of lung cancer oncogenesis.}},
  author       = {{Wang, Xiangdong and Zhang, Yong and Nilsson, Carol and Berven, Frode and Andrén, Per E. and Carlsohn, Elisabet and Horvatovich, Peter and Malm, Johan and Fuentes, Manuel and Végvári, Ákos and Welinder, Charlotte and Fehniger, Thomas and Rezeli, Melinda and Edula, Goutham and Nishimura, Toshihide and Marko-Varga, György}},
  issn         = {{0167-7659}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{217--226}},
  publisher    = {{Springer}},
  series       = {{Cancer and Metastasis Reviews}},
  title        = {{Association of Chromosome 19 to Lung Cancer Genotypes and Phenotypes}},
  url          = {{http://dx.doi.org/10.1007/s10555-015-9556-2}},
  doi          = {{10.1007/s10555-015-9556-2}},
  volume       = {{34}},
  year         = {{2015}},
}