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Association of Chromosome 19 to Lung Cancer Genotypes and Phenotypes

Wang, Xiangdong; Zhang, Yong; Nilsson, Carol LU ; Berven, Frode; Andrén, Per E.; Carlsohn, Elisabet; Horvatovich, Peter; Malm, Johan LU ; Fuentes, Manuel and Végvári, Ákos LU , et al. (2015) In Cancer Metastasis Review 34(2). p.217-226
Abstract
The Chromosome 19 Consortium, a part of the Chromosome-Centric Human Proteome Project (C-HPP, http://​www.​C-HPP.​org), is tasked with the understanding chromosome 19 functions at the gene and protein levels, as well as their roles in lung oncogenesis. Comparative genomic hybridization (CGH) studies revealed chromosome aberration in lung cancer subtypes, including ADC, SCC, LCC, and SCLC. The most common abnormality is 19p loss and 19q gain. Sixty-four aberrant genes identified in previous genomic studies and their encoded protein functions were further validated in the neXtProt database (http://​www.​nextprot.​org/​). Among those, the loss of tumor suppressor genes STK11, MUM1, KISS1R (19p13.3), and BRG1 (19p13.13) is associated with lung... (More)
The Chromosome 19 Consortium, a part of the Chromosome-Centric Human Proteome Project (C-HPP, http://​www.​C-HPP.​org), is tasked with the understanding chromosome 19 functions at the gene and protein levels, as well as their roles in lung oncogenesis. Comparative genomic hybridization (CGH) studies revealed chromosome aberration in lung cancer subtypes, including ADC, SCC, LCC, and SCLC. The most common abnormality is 19p loss and 19q gain. Sixty-four aberrant genes identified in previous genomic studies and their encoded protein functions were further validated in the neXtProt database (http://​www.​nextprot.​org/​). Among those, the loss of tumor suppressor genes STK11, MUM1, KISS1R (19p13.3), and BRG1 (19p13.13) is associated with lung oncogenesis or remote metastasis. Gene aberrations include translocation t(15, 19) (q13, p13.1) fusion oncogene BRD4-NUT, DNA repair genes (ERCC1, ERCC2, XRCC1), TGFβ1 pathway activation genes (TGFB1, LTBP4), Dyrk1B, and potential oncogenesis protector genes such as NFkB pathway inhibition genes (NFKBIB, PPP1R13L) and EGLN2. In conclusion, neXtProt is an effective resource for the validation of gene aberrations identified in genomic studies. It promises to enhance our understanding of lung cancer oncogenesis. (Less)
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Cancer Metastasis Review
volume
34
issue
2
pages
217 - 226
publisher
Springer
external identifiers
  • wos:000358743300006
  • scopus:84938417469
ISSN
0167-7659
DOI
10.1007/s10555-015-9556-2
language
English
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yes
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3cf3a03a-f36a-45df-9fa9-8c264c1b3607 (old id 5218942)
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2015-05-22 10:35:50
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2017-10-01 03:20:14
@article{3cf3a03a-f36a-45df-9fa9-8c264c1b3607,
  abstract     = {The Chromosome 19 Consortium, a part of the Chromosome-Centric Human Proteome Project (C-HPP, http://​www.​C-HPP.​org), is tasked with the understanding chromosome 19 functions at the gene and protein levels, as well as their roles in lung oncogenesis. Comparative genomic hybridization (CGH) studies revealed chromosome aberration in lung cancer subtypes, including ADC, SCC, LCC, and SCLC. The most common abnormality is 19p loss and 19q gain. Sixty-four aberrant genes identified in previous genomic studies and their encoded protein functions were further validated in the neXtProt database (http://​www.​nextprot.​org/​). Among those, the loss of tumor suppressor genes STK11, MUM1, KISS1R (19p13.3), and BRG1 (19p13.13) is associated with lung oncogenesis or remote metastasis. Gene aberrations include translocation t(15, 19) (q13, p13.1) fusion oncogene BRD4-NUT, DNA repair genes (ERCC1, ERCC2, XRCC1), TGFβ1 pathway activation genes (TGFB1, LTBP4), Dyrk1B, and potential oncogenesis protector genes such as NFkB pathway inhibition genes (NFKBIB, PPP1R13L) and EGLN2. In conclusion, neXtProt is an effective resource for the validation of gene aberrations identified in genomic studies. It promises to enhance our understanding of lung cancer oncogenesis.},
  author       = {Wang, Xiangdong and Zhang, Yong and Nilsson, Carol and Berven, Frode and Andrén, Per E. and Carlsohn, Elisabet and Horvatovich, Peter and Malm, Johan and Fuentes, Manuel and Végvári, Ákos and Welinder, Charlotte and Fehniger, Thomas and Rezeli, Melinda and Edula, Goutham and Nishimura, Toshihide and Marko-Varga, György},
  issn         = {0167-7659},
  language     = {eng},
  number       = {2},
  pages        = {217--226},
  publisher    = {Springer},
  series       = {Cancer Metastasis Review},
  title        = {Association of Chromosome 19 to Lung Cancer Genotypes and Phenotypes},
  url          = {http://dx.doi.org/10.1007/s10555-015-9556-2},
  volume       = {34},
  year         = {2015},
}