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Disease-specific Hospitalizations among 5-Year Survivors of Hepatoblastoma : A Nordic Population-based Cohort Study

, ; Bonnesen, Trine G.; Asdahl, Peter H.; De Fine Licht, Sofie; Gudmundsdottir, Thorgerdur; Holmqvist, Anna S. LU ; Madanat-Harjuoja, Laura Maria; Tryggvadottir, Laufey; Winther, Jeanette F. and Hasle, Henrik (2019) In Journal of Pediatric Hematology/Oncology1995-01-01+01:00 41(3). p.181-186
Abstract
Introduction: The long-term risk of somatic disease in hepatoblastoma survivors has not been thoroughly evaluated in previous studies. In this population-based study of 86 five-year HB survivors, we used inpatient registers to evaluate the risk for a range of somatic diseases.

Methods: In total, 86 five-year survivors of hepatoblastoma were identified in the Nordic cancer registries from 1964 to 2008 and 152,231 population comparisons were selected. Study subjects were followed in national hospital registries for somatic disease classified into 12 main diagnostic groups. Standardized hospitalization rate ratios (RRs) and absolute excess risks were calculated.

Results: After a median follow-up of 11 years, 35 of the 86... (More)
Introduction: The long-term risk of somatic disease in hepatoblastoma survivors has not been thoroughly evaluated in previous studies. In this population-based study of 86 five-year HB survivors, we used inpatient registers to evaluate the risk for a range of somatic diseases.

Methods: In total, 86 five-year survivors of hepatoblastoma were identified in the Nordic cancer registries from 1964 to 2008 and 152,231 population comparisons were selected. Study subjects were followed in national hospital registries for somatic disease classified into 12 main diagnostic groups. Standardized hospitalization rate ratios (RRs) and absolute excess risks were calculated.

Results: After a median follow-up of 11 years, 35 of the 86 five-year hepatoblastoma survivors had been hospitalized with a total of 69 hospitalizations, resulting in an RR of 2.7 (95% confidence interval [CI], 2.2-3.5) and an overall absolute excess risk of 4.2 per 100 person-years. Highest risk was seen for benign neoplasms (RR=16) with 6 hospitalizations for benign neoplasms in the colon and one in rectum.

Conclusions: The pattern of hospitalizations found in this first comprehensive follow-up of hepatoblastoma survivors seems reassuring. Less than 50% of the 5-year survivors had been hospitalized and often for diseases that were not severe or life-threatening.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
childhood cancer, disease burden, hepatoblastoma, late complications, survivorship
in
Journal of Pediatric Hematology/Oncology1995-01-01+01:00
volume
41
issue
3
pages
181 - 186
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85058842994
ISSN
1077-4114
DOI
10.1097/MPH.0000000000001378
language
English
LU publication?
yes
id
524f5214-a17f-4348-9bb6-3f44af1516ae
date added to LUP
2019-01-10 12:27:35
date last changed
2019-05-27 17:07:03
@article{524f5214-a17f-4348-9bb6-3f44af1516ae,
  abstract     = {Introduction: The long-term risk of somatic disease in hepatoblastoma survivors has not been thoroughly evaluated in previous studies. In this population-based study of 86 five-year HB survivors, we used inpatient registers to evaluate the risk for a range of somatic diseases.<br/><br/>Methods: In total, 86 five-year survivors of hepatoblastoma were identified in the Nordic cancer registries from 1964 to 2008 and 152,231 population comparisons were selected. Study subjects were followed in national hospital registries for somatic disease classified into 12 main diagnostic groups. Standardized hospitalization rate ratios (RRs) and absolute excess risks were calculated.<br/><br/>Results: After a median follow-up of 11 years, 35 of the 86 five-year hepatoblastoma survivors had been hospitalized with a total of 69 hospitalizations, resulting in an RR of 2.7 (95% confidence interval [CI], 2.2-3.5) and an overall absolute excess risk of 4.2 per 100 person-years. Highest risk was seen for benign neoplasms (RR=16) with 6 hospitalizations for benign neoplasms in the colon and one in rectum.<br/><br/>Conclusions: The pattern of hospitalizations found in this first comprehensive follow-up of hepatoblastoma survivors seems reassuring. Less than 50% of the 5-year survivors had been hospitalized and often for diseases that were not severe or life-threatening.<br/>},
  author       = {,  and Bonnesen, Trine G. and Asdahl, Peter H. and De Fine Licht, Sofie and Gudmundsdottir, Thorgerdur and Holmqvist, Anna S. and Madanat-Harjuoja, Laura Maria and Tryggvadottir, Laufey and Winther, Jeanette F. and Hasle, Henrik},
  issn         = {1077-4114},
  keyword      = {childhood cancer,disease burden,hepatoblastoma,late complications,survivorship},
  language     = {eng},
  number       = {3},
  pages        = {181--186},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Pediatric Hematology/Oncology1995-01-01+01:00},
  title        = {Disease-specific Hospitalizations among 5-Year Survivors of Hepatoblastoma : A Nordic Population-based Cohort Study},
  url          = {http://dx.doi.org/10.1097/MPH.0000000000001378},
  volume       = {41},
  year         = {2019},
}