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Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review.

Jekel, Katrin ; Damian, Marinella ; Wattmo, Carina LU ; Hausner, Lucrezia ; Bullock, Roger ; Connelly, Peter J ; Dubois, Bruno ; Eriksdotter, Maria ; Ewers, Michael and Graessel, Elmar , et al. (2015) In Alzheimer's Research & Therapy 7(1).
Abstract
Introduction: There is a growing body of evidence that subtle deficits in instrumental activities of daily living (IADL) may be present in mild cognitive impairment (MCI). However, it is not clear if there are IADL domains that are consistently affected across patients with MCI. In this systematic review, therefore, we aimed to summarize research results regarding the performance of MCI patients in specific IADL (sub)domains compared with persons who are cognitively normal and/or patients with dementia.

Methods: The databases PsycINFO, PubMed and Web of Science were searched for relevant literature in December 2013. Publications from 1999 onward were considered for inclusion. Altogether, 497 articles were retrieved. Reference... (More)
Introduction: There is a growing body of evidence that subtle deficits in instrumental activities of daily living (IADL) may be present in mild cognitive impairment (MCI). However, it is not clear if there are IADL domains that are consistently affected across patients with MCI. In this systematic review, therefore, we aimed to summarize research results regarding the performance of MCI patients in specific IADL (sub)domains compared with persons who are cognitively normal and/or patients with dementia.

Methods: The databases PsycINFO, PubMed and Web of Science were searched for relevant literature in December 2013. Publications from 1999 onward were considered for inclusion. Altogether, 497 articles were retrieved. Reference lists of selected articles were searched for potentially relevant articles. After screening the abstracts of these 497 articles, 37 articles were included in this review.

Results: In 35 studies, IADL deficits (such as problems with medication intake, telephone use, keeping appointments, finding things at home and using everyday technology) were documented in patients with MCI. Financial capacity in patients with MCI was affected in the majority of studies. Effect sizes for group differences between patients with MCI and healthy controls were predominantly moderate to large. Performance-based instruments showed slight advantages (in terms of effect sizes) in detecting group differences in IADL functioning between patients with MCI, patients with Alzheimer’s disease and healthy controls.

Conclusion: IADL requiring higher neuropsychological functioning seem to be most severely affected in patients with MCI. A reliable identification of such deficits is necessary, as patients with MCI with IADL deficits seem to have a higher risk of converting to dementia than patients with MCI without IADL deficits. The use of assessment tools specifically designed and validated for patients with MCI is therefore strongly recommended. Furthermore, the development of performance-based assessment instruments should be intensified, as they allow a valid and reliable assessment of subtle IADL deficits in MCI, even if a proxy is not available. Another important point to consider when designing new scales is the inclusion of technology-associated IADL. Novel instruments for clinical practice should be time-efficient and easy to administer. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alzheimer's Research & Therapy
volume
7
issue
1
article number
17
publisher
BioMed Central (BMC)
external identifiers
  • pmid:25815063
  • scopus:84925661571
  • pmid:25815063
  • wos:000411245300001
ISSN
1758-9193
DOI
10.1186/s13195-015-0099-0
language
English
LU publication?
yes
id
e0e064f9-0db5-4b5d-8535-ee4dcb5f53a7 (old id 5257526)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25815063?dopt=Abstract
date added to LUP
2016-04-01 13:30:18
date last changed
2022-05-19 19:42:27
@article{e0e064f9-0db5-4b5d-8535-ee4dcb5f53a7,
  abstract     = {{Introduction: There is a growing body of evidence that subtle deficits in instrumental activities of daily living (IADL) may be present in mild cognitive impairment (MCI). However, it is not clear if there are IADL domains that are consistently affected across patients with MCI. In this systematic review, therefore, we aimed to summarize research results regarding the performance of MCI patients in specific IADL (sub)domains compared with persons who are cognitively normal and/or patients with dementia.<br/><br>
Methods: The databases PsycINFO, PubMed and Web of Science were searched for relevant literature in December 2013. Publications from 1999 onward were considered for inclusion. Altogether, 497 articles were retrieved. Reference lists of selected articles were searched for potentially relevant articles. After screening the abstracts of these 497 articles, 37 articles were included in this review.<br/><br>
Results: In 35 studies, IADL deficits (such as problems with medication intake, telephone use, keeping appointments, finding things at home and using everyday technology) were documented in patients with MCI. Financial capacity in patients with MCI was affected in the majority of studies. Effect sizes for group differences between patients with MCI and healthy controls were predominantly moderate to large. Performance-based instruments showed slight advantages (in terms of effect sizes) in detecting group differences in IADL functioning between patients with MCI, patients with Alzheimer’s disease and healthy controls.<br/><br>
Conclusion: IADL requiring higher neuropsychological functioning seem to be most severely affected in patients with MCI. A reliable identification of such deficits is necessary, as patients with MCI with IADL deficits seem to have a higher risk of converting to dementia than patients with MCI without IADL deficits. The use of assessment tools specifically designed and validated for patients with MCI is therefore strongly recommended. Furthermore, the development of performance-based assessment instruments should be intensified, as they allow a valid and reliable assessment of subtle IADL deficits in MCI, even if a proxy is not available. Another important point to consider when designing new scales is the inclusion of technology-associated IADL. Novel instruments for clinical practice should be time-efficient and easy to administer.}},
  author       = {{Jekel, Katrin and Damian, Marinella and Wattmo, Carina and Hausner, Lucrezia and Bullock, Roger and Connelly, Peter J and Dubois, Bruno and Eriksdotter, Maria and Ewers, Michael and Graessel, Elmar and Kramberger, Milica G and Law, Emma and Mecocci, Patrizia and Molinuevo, José L and Nygård, Louise and Olde-Rikkert, Marcel Gm and Orgogozo, Jean-Marc and Pasquier, Florence and Peres, Karine and Salmon, Eric and Sikkes, Sietske Am and Sobow, Tomasz and Spiegel, René and Tsolaki, Magda and Winblad, Bengt and Frölich, Lutz}},
  issn         = {{1758-9193}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Alzheimer's Research & Therapy}},
  title        = {{Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review.}},
  url          = {{https://lup.lub.lu.se/search/files/3409944/8230197.pdf}},
  doi          = {{10.1186/s13195-015-0099-0}},
  volume       = {{7}},
  year         = {{2015}},
}