Human antibody technology and the development of antibodies against cytomegalovirus.
Ohlin, Mats LU
and Söderberg-Nauclér, Cecilia
(2015)
In Molecular Immunology
67(2).
p.153-170
- Abstract
- Cytomegalovirus (CMV) is a virus that causes chronic infections in a large set of the population. It may cause severe disease in immunocompromised individuals, is linked to immunosenescence and implied to play an important role in the pathogenesis of cardiovascular diseases and cancer. Modulation of the immune system's abilities to manage the virus represent a highly viable therapeutic option and passive immunotherapy with polyclonal antibody preparations is already in clinical use. Defined monoclonal antibodies offer many advantages over polyclonal antibodies purified from serum. Human CMV-specific monoclonal antibodies have consequently been thoroughly investigated with respect to their potential in the treatment of diseases caused by... (More)
- Cytomegalovirus (CMV) is a virus that causes chronic infections in a large set of the population. It may cause severe disease in immunocompromised individuals, is linked to immunosenescence and implied to play an important role in the pathogenesis of cardiovascular diseases and cancer. Modulation of the immune system's abilities to manage the virus represent a highly viable therapeutic option and passive immunotherapy with polyclonal antibody preparations is already in clinical use. Defined monoclonal antibodies offer many advantages over polyclonal antibodies purified from serum. Human CMV-specific monoclonal antibodies have consequently been thoroughly investigated with respect to their potential in the treatment of diseases caused by CMV. Recent advances in human antibody technology have substantially expanded the breadth of antibodies for such applications. This review summarizes the fundamental basis for treating CMV disease by use of antibodies, the basic technologies to be used to develop such antibodies, and relevant human antibody specificities available to target this virus. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5257790
- author
- Ohlin, Mats
LU
and Söderberg-Nauclér, Cecilia
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Molecular Immunology
- volume
- 67
- issue
- 2
- pages
- 153 - 170
- publisher
- Pergamon Press Ltd.
- external identifiers
-
- pmid:25802091
- wos:000361922200015
- scopus:84939267590
- pmid:25802091
- ISSN
- 1872-9142
- DOI
- 10.1016/j.molimm.2015.02.026
- language
- English
- LU publication?
- yes
- id
- 88b3603b-783a-49a8-98c0-7a459bbfb1b5 (old id 5257790)
- date added to LUP
- 2016-04-01 10:30:30
- date last changed
- 2022-03-04 20:15:23
@article{88b3603b-783a-49a8-98c0-7a459bbfb1b5,
abstract = {{Cytomegalovirus (CMV) is a virus that causes chronic infections in a large set of the population. It may cause severe disease in immunocompromised individuals, is linked to immunosenescence and implied to play an important role in the pathogenesis of cardiovascular diseases and cancer. Modulation of the immune system's abilities to manage the virus represent a highly viable therapeutic option and passive immunotherapy with polyclonal antibody preparations is already in clinical use. Defined monoclonal antibodies offer many advantages over polyclonal antibodies purified from serum. Human CMV-specific monoclonal antibodies have consequently been thoroughly investigated with respect to their potential in the treatment of diseases caused by CMV. Recent advances in human antibody technology have substantially expanded the breadth of antibodies for such applications. This review summarizes the fundamental basis for treating CMV disease by use of antibodies, the basic technologies to be used to develop such antibodies, and relevant human antibody specificities available to target this virus.}},
author = {{Ohlin, Mats and Söderberg-Nauclér, Cecilia}},
issn = {{1872-9142}},
language = {{eng}},
number = {{2}},
pages = {{153--170}},
publisher = {{Pergamon Press Ltd.}},
series = {{Molecular Immunology}},
title = {{Human antibody technology and the development of antibodies against cytomegalovirus.}},
url = {{http://dx.doi.org/10.1016/j.molimm.2015.02.026}},
doi = {{10.1016/j.molimm.2015.02.026}},
volume = {{67}},
year = {{2015}},
}