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Human antibody technology and the development of antibodies against cytomegalovirus.

Ohlin, Mats LU and Söderberg-Nauclér, Cecilia (2015) In Molecular Immunology 67(2). p.153-170
Abstract
Cytomegalovirus (CMV) is a virus that causes chronic infections in a large set of the population. It may cause severe disease in immunocompromised individuals, is linked to immunosenescence and implied to play an important role in the pathogenesis of cardiovascular diseases and cancer. Modulation of the immune system's abilities to manage the virus represent a highly viable therapeutic option and passive immunotherapy with polyclonal antibody preparations is already in clinical use. Defined monoclonal antibodies offer many advantages over polyclonal antibodies purified from serum. Human CMV-specific monoclonal antibodies have consequently been thoroughly investigated with respect to their potential in the treatment of diseases caused by... (More)
Cytomegalovirus (CMV) is a virus that causes chronic infections in a large set of the population. It may cause severe disease in immunocompromised individuals, is linked to immunosenescence and implied to play an important role in the pathogenesis of cardiovascular diseases and cancer. Modulation of the immune system's abilities to manage the virus represent a highly viable therapeutic option and passive immunotherapy with polyclonal antibody preparations is already in clinical use. Defined monoclonal antibodies offer many advantages over polyclonal antibodies purified from serum. Human CMV-specific monoclonal antibodies have consequently been thoroughly investigated with respect to their potential in the treatment of diseases caused by CMV. Recent advances in human antibody technology have substantially expanded the breadth of antibodies for such applications. This review summarizes the fundamental basis for treating CMV disease by use of antibodies, the basic technologies to be used to develop such antibodies, and relevant human antibody specificities available to target this virus. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular Immunology
volume
67
issue
2
pages
153 - 170
publisher
Pergamon
external identifiers
  • pmid:25802091
  • wos:000361922200015
  • scopus:84939267590
ISSN
1872-9142
DOI
10.1016/j.molimm.2015.02.026
language
English
LU publication?
yes
id
88b3603b-783a-49a8-98c0-7a459bbfb1b5 (old id 5257790)
date added to LUP
2015-04-14 11:12:20
date last changed
2017-08-13 03:14:15
@article{88b3603b-783a-49a8-98c0-7a459bbfb1b5,
  abstract     = {Cytomegalovirus (CMV) is a virus that causes chronic infections in a large set of the population. It may cause severe disease in immunocompromised individuals, is linked to immunosenescence and implied to play an important role in the pathogenesis of cardiovascular diseases and cancer. Modulation of the immune system's abilities to manage the virus represent a highly viable therapeutic option and passive immunotherapy with polyclonal antibody preparations is already in clinical use. Defined monoclonal antibodies offer many advantages over polyclonal antibodies purified from serum. Human CMV-specific monoclonal antibodies have consequently been thoroughly investigated with respect to their potential in the treatment of diseases caused by CMV. Recent advances in human antibody technology have substantially expanded the breadth of antibodies for such applications. This review summarizes the fundamental basis for treating CMV disease by use of antibodies, the basic technologies to be used to develop such antibodies, and relevant human antibody specificities available to target this virus.},
  author       = {Ohlin, Mats and Söderberg-Nauclér, Cecilia},
  issn         = {1872-9142},
  language     = {eng},
  number       = {2},
  pages        = {153--170},
  publisher    = {Pergamon},
  series       = {Molecular Immunology},
  title        = {Human antibody technology and the development of antibodies against cytomegalovirus.},
  url          = {http://dx.doi.org/10.1016/j.molimm.2015.02.026},
  volume       = {67},
  year         = {2015},
}