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Vorinostat in patients with advanced malignant pleural mesothelioma who have progressed on previous chemotherapy (VANTAGE-014): a phase 3, double-blind, randomised, placebo-controlled trial.

Krug, Lee M; Kindler, Hedy L; Calvert, Hilary; Manegold, Christian; Tsao, Anne S; Fennell, Dean; Öhman, Ronny LU ; Plummer, Ruth; Eberhardt, Wilfried E E and Fukuoka, Kazuya, et al. (2015) In The Lancet Oncology 16(4). p.447-456
Abstract
Vorinostat is a histone deacetylase inhibitor that changes gene expression and protein activity. On the basis of the clinical benefit reported in patients with malignant pleural mesothelioma treated in a phase 1 study of vorinostat, we designed this phase 3 trial to investigate whether vorinostat given as a second-line or third-line therapy improved patients' overall survival.
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Contribution to journal
publication status
published
subject
in
The Lancet Oncology
volume
16
issue
4
pages
447 - 456
publisher
Elsevier
external identifiers
  • pmid:25800891
  • wos:000352020000051
  • scopus:84933526775
ISSN
1474-5488
DOI
10.1016/S1470-2045(15)70056-2
language
English
LU publication?
yes
id
68518d96-46b7-4406-9f98-24f7eb71bf72 (old id 5257808)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25800891?dopt=Abstract
date added to LUP
2015-04-05 13:37:15
date last changed
2017-11-05 03:24:23
@article{68518d96-46b7-4406-9f98-24f7eb71bf72,
  abstract     = {Vorinostat is a histone deacetylase inhibitor that changes gene expression and protein activity. On the basis of the clinical benefit reported in patients with malignant pleural mesothelioma treated in a phase 1 study of vorinostat, we designed this phase 3 trial to investigate whether vorinostat given as a second-line or third-line therapy improved patients' overall survival.},
  author       = {Krug, Lee M and Kindler, Hedy L and Calvert, Hilary and Manegold, Christian and Tsao, Anne S and Fennell, Dean and Öhman, Ronny and Plummer, Ruth and Eberhardt, Wilfried E E and Fukuoka, Kazuya and Gaafar, Rabab M and Lafitte, Jean-Jacques and Hillerdal, Gunnar and Chu, Quincy and Buikhuisen, Wieneke A and Lubiniecki, Gregory M and Sun, Xing and Smith, Margaret and Baas, Paul},
  issn         = {1474-5488},
  language     = {eng},
  number       = {4},
  pages        = {447--456},
  publisher    = {Elsevier},
  series       = {The Lancet Oncology},
  title        = {Vorinostat in patients with advanced malignant pleural mesothelioma who have progressed on previous chemotherapy (VANTAGE-014): a phase 3, double-blind, randomised, placebo-controlled trial.},
  url          = {http://dx.doi.org/10.1016/S1470-2045(15)70056-2},
  volume       = {16},
  year         = {2015},
}