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Genetics of type 2 diabetes-pitfalls and possibilities.

Prasad, Rashmi LU and Groop, Leif LU (2015) In Genes 6(1). p.87-123
Abstract
Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between genetic, epigenetic and environmental factors. While the major environmental factors, diet and activity level, are well known, identification of the genetic factors has been a challenge. However, recent years have seen an explosion of genetic variants in risk and protection of T2D due to the technical development that has allowed genome-wide association studies and next-generation sequencing. Today, more than 120 variants have been convincingly replicated for association with T2D and many more with diabetes-related traits. Still, these variants only explain a small proportion of the total heritability of T2D. In this review, we address the... (More)
Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between genetic, epigenetic and environmental factors. While the major environmental factors, diet and activity level, are well known, identification of the genetic factors has been a challenge. However, recent years have seen an explosion of genetic variants in risk and protection of T2D due to the technical development that has allowed genome-wide association studies and next-generation sequencing. Today, more than 120 variants have been convincingly replicated for association with T2D and many more with diabetes-related traits. Still, these variants only explain a small proportion of the total heritability of T2D. In this review, we address the possibilities to elucidate the genetic landscape of T2D as well as discuss pitfalls with current strategies to identify the elusive unknown heritability including the possibility that our definition of diabetes and its subgroups is imprecise and thereby makes the identification of genetic causes difficult. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genes
volume
6
issue
1
pages
87 - 123
publisher
MDPI AG
external identifiers
  • pmid:25774817
  • wos:000352055600005
  • scopus:84925347828
ISSN
2073-4425
DOI
10.3390/genes6010087
language
English
LU publication?
yes
id
3d1d8830-e05d-4020-812a-47aec7c41885 (old id 5258559)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25774817?dopt=Abstract
date added to LUP
2015-04-03 20:15:47
date last changed
2017-10-22 04:00:56
@article{3d1d8830-e05d-4020-812a-47aec7c41885,
  abstract     = {Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between genetic, epigenetic and environmental factors. While the major environmental factors, diet and activity level, are well known, identification of the genetic factors has been a challenge. However, recent years have seen an explosion of genetic variants in risk and protection of T2D due to the technical development that has allowed genome-wide association studies and next-generation sequencing. Today, more than 120 variants have been convincingly replicated for association with T2D and many more with diabetes-related traits. Still, these variants only explain a small proportion of the total heritability of T2D. In this review, we address the possibilities to elucidate the genetic landscape of T2D as well as discuss pitfalls with current strategies to identify the elusive unknown heritability including the possibility that our definition of diabetes and its subgroups is imprecise and thereby makes the identification of genetic causes difficult.},
  author       = {Prasad, Rashmi and Groop, Leif},
  issn         = {2073-4425},
  language     = {eng},
  number       = {1},
  pages        = {87--123},
  publisher    = {MDPI AG},
  series       = {Genes},
  title        = {Genetics of type 2 diabetes-pitfalls and possibilities.},
  url          = {http://dx.doi.org/10.3390/genes6010087},
  volume       = {6},
  year         = {2015},
}