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The DEK oncoprotein and its emerging roles in gene regulation.

Sandén, Carl LU and Gullberg, Urban LU (2015) In Leukemia 29(8). p.1632-1636
Abstract
The DEK oncogene is highly expressed in cells from most human tissues and overexpressed in a large and growing number of cancers. It also fuses with the NUP214 gene to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. Originally characterized as a member of this translocation, DEK has since been implicated in epigenetic and transcriptional regulation but its role in these processes is still elusive and intriguingly complex. Similarly multifaceted is its contribution to cellular transformation, affecting multiple cellular processes such as self-renewal, proliferation, differentiation, senescence and apoptosis. Recently, the roles of the DEK and DEK-NUP214 proteins have been elucidated by global analysis of DNA binding... (More)
The DEK oncogene is highly expressed in cells from most human tissues and overexpressed in a large and growing number of cancers. It also fuses with the NUP214 gene to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. Originally characterized as a member of this translocation, DEK has since been implicated in epigenetic and transcriptional regulation but its role in these processes is still elusive and intriguingly complex. Similarly multifaceted is its contribution to cellular transformation, affecting multiple cellular processes such as self-renewal, proliferation, differentiation, senescence and apoptosis. Recently, the roles of the DEK and DEK-NUP214 proteins have been elucidated by global analysis of DNA binding and gene expression as well as multiple functional studies. This review outlines recent advances in the understanding of the basic functions of the DEK protein and its role in leukemogenesis.Leukemia accepted article preview online, 13 March 2015. doi:10.1038/leu.2015.72. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Leukemia
volume
29
issue
8
pages
1632 - 1636
publisher
Nature Publishing Group
external identifiers
  • pmid:25765544
  • wos:000360937200002
  • scopus:84938995946
ISSN
1476-5551
DOI
10.1038/leu.2015.72
language
English
LU publication?
yes
id
e2418869-5457-48b5-a2ff-c84e08b763de (old id 5261709)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25765544?dopt=Abstract
date added to LUP
2015-04-03 17:49:12
date last changed
2017-08-20 03:12:15
@article{e2418869-5457-48b5-a2ff-c84e08b763de,
  abstract     = {The DEK oncogene is highly expressed in cells from most human tissues and overexpressed in a large and growing number of cancers. It also fuses with the NUP214 gene to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. Originally characterized as a member of this translocation, DEK has since been implicated in epigenetic and transcriptional regulation but its role in these processes is still elusive and intriguingly complex. Similarly multifaceted is its contribution to cellular transformation, affecting multiple cellular processes such as self-renewal, proliferation, differentiation, senescence and apoptosis. Recently, the roles of the DEK and DEK-NUP214 proteins have been elucidated by global analysis of DNA binding and gene expression as well as multiple functional studies. This review outlines recent advances in the understanding of the basic functions of the DEK protein and its role in leukemogenesis.Leukemia accepted article preview online, 13 March 2015. doi:10.1038/leu.2015.72.},
  author       = {Sandén, Carl and Gullberg, Urban},
  issn         = {1476-5551},
  language     = {eng},
  number       = {8},
  pages        = {1632--1636},
  publisher    = {Nature Publishing Group},
  series       = {Leukemia},
  title        = {The DEK oncoprotein and its emerging roles in gene regulation.},
  url          = {http://dx.doi.org/10.1038/leu.2015.72},
  volume       = {29},
  year         = {2015},
}