Prediction of Chemical Respiratory Sensitizers Using GARD, a Novel In Vitro Assay Based on a Genomic Biomarker Signature.
Forreryd, Andy LU ; Johansson, Henrik LU ; Albrekt, Ann-Sofie LU ; Borrebaeck, Carl LU and Lindstedt, Malin LU
(2015)
In PLoS ONE
10(3).
- Abstract
- Repeated exposure to certain low molecular weight (LMW) chemical compounds may result in development of allergic reactions in the skin or in the respiratory tract. In most cases, a certain LMW compound selectively sensitize the skin, giving rise to allergic contact dermatitis (ACD), or the respiratory tract, giving rise to occupational asthma (OA). To limit occurrence of allergic diseases, efforts are currently being made to develop predictive assays that accurately identify chemicals capable of inducing such reactions. However, while a few promising methods for prediction of skin sensitization have been described, to date no validated method, in vitro or in vivo, exists that is able to accurately classify chemicals as respiratory... (More)
- Repeated exposure to certain low molecular weight (LMW) chemical compounds may result in development of allergic reactions in the skin or in the respiratory tract. In most cases, a certain LMW compound selectively sensitize the skin, giving rise to allergic contact dermatitis (ACD), or the respiratory tract, giving rise to occupational asthma (OA). To limit occurrence of allergic diseases, efforts are currently being made to develop predictive assays that accurately identify chemicals capable of inducing such reactions. However, while a few promising methods for prediction of skin sensitization have been described, to date no validated method, in vitro or in vivo, exists that is able to accurately classify chemicals as respiratory sensitizers. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5264724
- author
- Forreryd, Andy
LU
; Johansson, Henrik
LU
; Albrekt, Ann-Sofie
LU
; Borrebaeck, Carl
LU
and Lindstedt, Malin
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 10
- issue
- 3
- article number
- e0118808
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:25760038
- wos:000351275000040
- scopus:84924529730
- pmid:25760038
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0118808
- language
- English
- LU publication?
- yes
- id
- 9fb7197e-a230-4268-b691-1f024c014d9f (old id 5264724)
- date added to LUP
- 2016-04-01 13:56:08
- date last changed
- 2024-10-10 09:58:56
@article{9fb7197e-a230-4268-b691-1f024c014d9f,
abstract = {{Repeated exposure to certain low molecular weight (LMW) chemical compounds may result in development of allergic reactions in the skin or in the respiratory tract. In most cases, a certain LMW compound selectively sensitize the skin, giving rise to allergic contact dermatitis (ACD), or the respiratory tract, giving rise to occupational asthma (OA). To limit occurrence of allergic diseases, efforts are currently being made to develop predictive assays that accurately identify chemicals capable of inducing such reactions. However, while a few promising methods for prediction of skin sensitization have been described, to date no validated method, in vitro or in vivo, exists that is able to accurately classify chemicals as respiratory sensitizers.}},
author = {{Forreryd, Andy and Johansson, Henrik and Albrekt, Ann-Sofie and Borrebaeck, Carl and Lindstedt, Malin}},
issn = {{1932-6203}},
language = {{eng}},
number = {{3}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Prediction of Chemical Respiratory Sensitizers Using GARD, a Novel In Vitro Assay Based on a Genomic Biomarker Signature.}},
url = {{http://dx.doi.org/10.1371/journal.pone.0118808}},
doi = {{10.1371/journal.pone.0118808}},
volume = {{10}},
year = {{2015}},
}