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Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials.

Mega, Jessica L; Stitziel, Nathan O; Smith, Gustav LU ; Chasman, Daniel I; Caulfield, Mark J; Devlin, James J; Nordio, Francesco; Hyde, Craig L; Cannon, Christopher P and Sacks, Frank M, et al. (2015) In The Lancet 385(9984). p.2264-2271
Abstract
Genetic variants have been associated with the risk of coronary heart disease. In this study, we tested whether or not a composite of these variants could ascertain the risk of both incident and recurrent coronary heart disease events and identify those individuals who derive greater clinical benefit from statin therapy.
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type
Contribution to journal
publication status
published
subject
in
The Lancet
volume
385
issue
9984
pages
2264 - 2271
publisher
Elsevier Limited
external identifiers
  • pmid:25748612
  • wos:000355943500028
  • scopus:84934277268
ISSN
1474-547X
DOI
10.1016/S0140-6736(14)61730-X
language
English
LU publication?
yes
id
bd85bff6-00de-42f4-9fcf-a2c816cebc92 (old id 5265071)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25748612?dopt=Abstract
date added to LUP
2015-04-02 15:37:02
date last changed
2017-11-12 03:11:45
@article{bd85bff6-00de-42f4-9fcf-a2c816cebc92,
  abstract     = {Genetic variants have been associated with the risk of coronary heart disease. In this study, we tested whether or not a composite of these variants could ascertain the risk of both incident and recurrent coronary heart disease events and identify those individuals who derive greater clinical benefit from statin therapy.},
  author       = {Mega, Jessica L and Stitziel, Nathan O and Smith, Gustav and Chasman, Daniel I and Caulfield, Mark J and Devlin, James J and Nordio, Francesco and Hyde, Craig L and Cannon, Christopher P and Sacks, Frank M and Poulter, Neil R and Sever, Peter S and Ridker, Paul M and Braunwald, Eugene and Melander, Olle and Kathiresan, Sekar and Sabatine, Marc S},
  issn         = {1474-547X},
  language     = {eng},
  number       = {9984},
  pages        = {2264--2271},
  publisher    = {Elsevier Limited},
  series       = {The Lancet},
  title        = {Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials.},
  url          = {http://dx.doi.org/10.1016/S0140-6736(14)61730-X},
  volume       = {385},
  year         = {2015},
}