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Effects of 10 to 30 years of lithium treatment on kidney function.

Aiff, Harald; Attman, Per-Ola; Aurell, Mattias; Bendz, Hans LU ; Ramsauer, Bernd; Schön, Staffan and Svedlund, Jan (2015) In Journal of Psychopharmacology 29(5). p.608-614
Abstract
Long-term lithium treatment is associated with end-stage renal disease, but there is little evidence of a clinically significant reduction in renal function in most patients. We previously found that 1.5% of people who took lithium from the 1960s and 1970s developed end-stage renal disease; however, none of the patients who started after 1980 had end-stage renal disease. Here we aimed to study the prevalence and extent of kidney damage during the course of long-term lithium treatment since 1980. We retrieved serum lithium and creatinine levels from 4879 patients examined between 1 January 1981 and 31 December 2010. Only patients who started their lithium treatment during the study period and had at least 10 years of cumulative treatment... (More)
Long-term lithium treatment is associated with end-stage renal disease, but there is little evidence of a clinically significant reduction in renal function in most patients. We previously found that 1.5% of people who took lithium from the 1960s and 1970s developed end-stage renal disease; however, none of the patients who started after 1980 had end-stage renal disease. Here we aimed to study the prevalence and extent of kidney damage during the course of long-term lithium treatment since 1980. We retrieved serum lithium and creatinine levels from 4879 patients examined between 1 January 1981 and 31 December 2010. Only patients who started their lithium treatment during the study period and had at least 10 years of cumulative treatment were included. The study group comprised 630 adult patients (402 women and 228 men) with normal creatinine levels at the start of lithium treatment. There was a yearly increase in median serum creatinine levels already from the first year of treatment. About one-third of the patients who had taken lithium for 10-29 years had evidence of chronic renal failure but only 5% were in the severe or very severe category. The results indicate that a substantial proportion of adult patients who are treated with lithium for more than a decade develop signs of renal functional impairment, also when treated according to modern therapeutic principles. Our results emphasise that lithium treatment requires continuous monitoring of kidney function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Psychopharmacology
volume
29
issue
5
pages
608 - 614
publisher
SAGE Publications Inc.
external identifiers
  • pmid:25735990
  • wos:000354903600010
  • scopus:84930662453
ISSN
1461-7285
DOI
10.1177/0269881115573808
language
English
LU publication?
yes
id
19cb3091-7cd3-4aec-8d06-5f41a3ae1d41 (old id 5265390)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25735990?dopt=Abstract
date added to LUP
2015-04-01 18:05:59
date last changed
2017-08-20 03:00:28
@article{19cb3091-7cd3-4aec-8d06-5f41a3ae1d41,
  abstract     = {Long-term lithium treatment is associated with end-stage renal disease, but there is little evidence of a clinically significant reduction in renal function in most patients. We previously found that 1.5% of people who took lithium from the 1960s and 1970s developed end-stage renal disease; however, none of the patients who started after 1980 had end-stage renal disease. Here we aimed to study the prevalence and extent of kidney damage during the course of long-term lithium treatment since 1980. We retrieved serum lithium and creatinine levels from 4879 patients examined between 1 January 1981 and 31 December 2010. Only patients who started their lithium treatment during the study period and had at least 10 years of cumulative treatment were included. The study group comprised 630 adult patients (402 women and 228 men) with normal creatinine levels at the start of lithium treatment. There was a yearly increase in median serum creatinine levels already from the first year of treatment. About one-third of the patients who had taken lithium for 10-29 years had evidence of chronic renal failure but only 5% were in the severe or very severe category. The results indicate that a substantial proportion of adult patients who are treated with lithium for more than a decade develop signs of renal functional impairment, also when treated according to modern therapeutic principles. Our results emphasise that lithium treatment requires continuous monitoring of kidney function.},
  author       = {Aiff, Harald and Attman, Per-Ola and Aurell, Mattias and Bendz, Hans and Ramsauer, Bernd and Schön, Staffan and Svedlund, Jan},
  issn         = {1461-7285},
  language     = {eng},
  number       = {5},
  pages        = {608--614},
  publisher    = {SAGE Publications Inc.},
  series       = {Journal of Psychopharmacology},
  title        = {Effects of 10 to 30 years of lithium treatment on kidney function.},
  url          = {http://dx.doi.org/10.1177/0269881115573808},
  volume       = {29},
  year         = {2015},
}