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Predicting Sensitivity to Adverse Lifestyle Risk Factors for Cardiometabolic Morbidity and Mortality

Pomares-Millan, Hugo LU orcid ; Poveda, Alaitz LU orcid ; Atabaki Pasdar, Naeimeh LU orcid ; Björk, Jonas LU ; Ohlsson, Mattias LU orcid ; Giordano, Nick LU and Franks, Paul LU (2022) In Nutrients 14(15). p.1-13
Abstract
People appear to vary in their susceptibility to lifestyle risk factors for cardiometabolic disease; determining a priori who is most sensitive may help optimize the timing, design, and delivery of preventative interventions. We aimed to ascertain a person's degree of resilience or sensitivity to adverse lifestyle exposures and determine whether these classifications help predict cardiometabolic disease later in life; we pooled data from two population-based Swedish prospective cohort studies (n = 53,507), and we contrasted an individual's cardiometabolic biomarker profile with the profile predicted for them given their lifestyle exposure characteristics using a quantile random forest approach. People who were classed as 'sensitive' to... (More)
People appear to vary in their susceptibility to lifestyle risk factors for cardiometabolic disease; determining a priori who is most sensitive may help optimize the timing, design, and delivery of preventative interventions. We aimed to ascertain a person's degree of resilience or sensitivity to adverse lifestyle exposures and determine whether these classifications help predict cardiometabolic disease later in life; we pooled data from two population-based Swedish prospective cohort studies (n = 53,507), and we contrasted an individual's cardiometabolic biomarker profile with the profile predicted for them given their lifestyle exposure characteristics using a quantile random forest approach. People who were classed as 'sensitive' to hypertension- and dyslipidemia-related lifestyle exposures were at higher risk of developing cardiovascular disease (CVD, hazards ratio 1.6 (95% CI: 1.3, 1.91)), compared with the general population. No differences were observed for type 2 diabetes (T2D) risk. Here, we report a novel approach to identify individuals who are especially sensitive to adverse lifestyle exposures and who are at higher risk of subsequent cardiovascular events. Early preventive interventions may be needed in this subgroup. (Less)
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author
; ; ; ; ; and
contributor
Johansson, Ingegerd
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nutrients
volume
14
issue
15
article number
3171
pages
1 - 13
publisher
MDPI AG
external identifiers
  • scopus:85136515127
  • pmid:35956347
ISSN
2072-6643
DOI
10.3390/nu14153171
language
English
LU publication?
yes
id
5277969e-9f61-4cfb-aa4e-e2768f15c84d
date added to LUP
2022-09-20 15:45:36
date last changed
2022-09-22 03:00:01
@article{5277969e-9f61-4cfb-aa4e-e2768f15c84d,
  abstract     = {{People appear to vary in their susceptibility to lifestyle risk factors for cardiometabolic disease; determining a priori who is most sensitive may help optimize the timing, design, and delivery of preventative interventions. We aimed to ascertain a person's degree of resilience or sensitivity to adverse lifestyle exposures and determine whether these classifications help predict cardiometabolic disease later in life; we pooled data from two population-based Swedish prospective cohort studies (n = 53,507), and we contrasted an individual's cardiometabolic biomarker profile with the profile predicted for them given their lifestyle exposure characteristics using a quantile random forest approach. People who were classed as 'sensitive' to hypertension- and dyslipidemia-related lifestyle exposures were at higher risk of developing cardiovascular disease (CVD, hazards ratio 1.6 (95% CI: 1.3, 1.91)), compared with the general population. No differences were observed for type 2 diabetes (T2D) risk. Here, we report a novel approach to identify individuals who are especially sensitive to adverse lifestyle exposures and who are at higher risk of subsequent cardiovascular events. Early preventive interventions may be needed in this subgroup.}},
  author       = {{Pomares-Millan, Hugo and Poveda, Alaitz and Atabaki Pasdar, Naeimeh and Björk, Jonas and Ohlsson, Mattias and Giordano, Nick and Franks, Paul}},
  issn         = {{2072-6643}},
  language     = {{eng}},
  number       = {{15}},
  pages        = {{1--13}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{Predicting Sensitivity to Adverse Lifestyle Risk Factors for Cardiometabolic Morbidity and Mortality}},
  url          = {{http://dx.doi.org/10.3390/nu14153171}},
  doi          = {{10.3390/nu14153171}},
  volume       = {{14}},
  year         = {{2022}},
}