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Trends in cutaneous malignant melanoma in Sweden 1997-2011: thinner tumours and improved survival among men

Lyth, J.; Eriksson, H.; Hansson, J.; Ingvar, Christian LU ; Jansson, M.; Lapins, J.; Mansson-Brahme, E.; Naredi, P.; Stierner, U. and Ullenhag, G., et al. (2015) In British Journal of Dermatology 172(3). p.700-706
Abstract
Background Both patient survival and the proportion of patients diagnosed with thin cutaneous malignant melanoma (CMM) have been steadily rising in Sweden as in most Western countries, although the rate of improvement in survival appears to have declined in Sweden at the end of the last millennium. Objectives To analyse the most recent trends in the distribution of tumour thickness (T category) as well as CMM-specific survival in Swedish patients diagnosed during 1997-2011. Methods This nationwide population-based study included 30 590 patients registered in the Swedish Melanoma Register (SMR) and diagnosed with a first primary invasive CMM during 1997-2011. The patients were followed through 2012 in the national Cause of Death Register.... (More)
Background Both patient survival and the proportion of patients diagnosed with thin cutaneous malignant melanoma (CMM) have been steadily rising in Sweden as in most Western countries, although the rate of improvement in survival appears to have declined in Sweden at the end of the last millennium. Objectives To analyse the most recent trends in the distribution of tumour thickness (T category) as well as CMM-specific survival in Swedish patients diagnosed during 1997-2011. Methods This nationwide population-based study included 30 590 patients registered in the Swedish Melanoma Register (SMR) and diagnosed with a first primary invasive CMM during 1997-2011. The patients were followed through 2012 in the national Cause of Death Register. Results Logistic and Cox regression analyses adjusting for age at diagnosis, tumour site and healthcare region were carried out. The odds ratio for being diagnosed with thicker tumours was significantly reduced (P < 0.001) and the CMM-specific survival significantly improved in men diagnosed during 2007-2011 compared with men diagnosed during 1997-2001 (hazard ratio = 0.81; 95% confidence interval 0.72-0.91; P < 0.001), while the corresponding differences for women were not significant. Women were diagnosed with significantly thicker tumours during 2002-2006 and a tendency towards decreased survival was observed compared with those diagnosed earlier (during 1997-2001) and later (during 2007-2011). Conclusions In Sweden, the CMMs of men are detected earlier over time and this seems to be followed by an improved CMM-specific survival for men. Women are still diagnosed with considerably thinner tumours and they experience a better survival than men. (Less)
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published
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British Journal of Dermatology
volume
172
issue
3
pages
700 - 706
publisher
Wiley-Blackwell
external identifiers
  • wos:000351400500029
  • scopus:84925307242
ISSN
1365-2133
DOI
10.1111/bjd.13483
language
English
LU publication?
yes
id
947891ff-6a90-494a-a78d-e6c1a1906b2f (old id 5293706)
date added to LUP
2015-05-04 08:33:51
date last changed
2017-11-12 03:02:43
@article{947891ff-6a90-494a-a78d-e6c1a1906b2f,
  abstract     = {Background Both patient survival and the proportion of patients diagnosed with thin cutaneous malignant melanoma (CMM) have been steadily rising in Sweden as in most Western countries, although the rate of improvement in survival appears to have declined in Sweden at the end of the last millennium. Objectives To analyse the most recent trends in the distribution of tumour thickness (T category) as well as CMM-specific survival in Swedish patients diagnosed during 1997-2011. Methods This nationwide population-based study included 30 590 patients registered in the Swedish Melanoma Register (SMR) and diagnosed with a first primary invasive CMM during 1997-2011. The patients were followed through 2012 in the national Cause of Death Register. Results Logistic and Cox regression analyses adjusting for age at diagnosis, tumour site and healthcare region were carried out. The odds ratio for being diagnosed with thicker tumours was significantly reduced (P &lt; 0.001) and the CMM-specific survival significantly improved in men diagnosed during 2007-2011 compared with men diagnosed during 1997-2001 (hazard ratio = 0.81; 95% confidence interval 0.72-0.91; P &lt; 0.001), while the corresponding differences for women were not significant. Women were diagnosed with significantly thicker tumours during 2002-2006 and a tendency towards decreased survival was observed compared with those diagnosed earlier (during 1997-2001) and later (during 2007-2011). Conclusions In Sweden, the CMMs of men are detected earlier over time and this seems to be followed by an improved CMM-specific survival for men. Women are still diagnosed with considerably thinner tumours and they experience a better survival than men.},
  author       = {Lyth, J. and Eriksson, H. and Hansson, J. and Ingvar, Christian and Jansson, M. and Lapins, J. and Mansson-Brahme, E. and Naredi, P. and Stierner, U. and Ullenhag, G. and Carstensen, J. and Lindholm, C.},
  issn         = {1365-2133},
  language     = {eng},
  number       = {3},
  pages        = {700--706},
  publisher    = {Wiley-Blackwell},
  series       = {British Journal of Dermatology},
  title        = {Trends in cutaneous malignant melanoma in Sweden 1997-2011: thinner tumours and improved survival among men},
  url          = {http://dx.doi.org/10.1111/bjd.13483},
  volume       = {172},
  year         = {2015},
}