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Predictors of severe self-reported disability in RA in a long-term follow-up study

Malm, Karina LU ; Bergman, Stefan LU ; Andersson, Maria LU and Bremander, Ann LU (2015) In Disability and Rehabilitation 37(8). p.686-691
Abstract
Purpose: Identify factors predictive for severe self-reported disability in patients with rheumatoid arthritis. Methods: Patients (n = 1910) were sent a questionnaire 5-18 years after disease onset. Outcomes were the Health Assessment Questionnaire (HAQ), Rheumatoid Arthritis Outcome Score (RAOS) and physical activity. The tertile of patients most affected by the disease were compared to those less affected. Proposed predictive factors were function, pain, general health, radiographic joint damage, swollen/tender joints and disease activity measures at baseline. Age, gender and disease duration were controlled for in logistic regression analyses. Results: Seventy-three percent (n = 1387) responded to the questionnaire, mean age 65 years... (More)
Purpose: Identify factors predictive for severe self-reported disability in patients with rheumatoid arthritis. Methods: Patients (n = 1910) were sent a questionnaire 5-18 years after disease onset. Outcomes were the Health Assessment Questionnaire (HAQ), Rheumatoid Arthritis Outcome Score (RAOS) and physical activity. The tertile of patients most affected by the disease were compared to those less affected. Proposed predictive factors were function, pain, general health, radiographic joint damage, swollen/tender joints and disease activity measures at baseline. Age, gender and disease duration were controlled for in logistic regression analyses. Results: Seventy-three percent (n = 1387) responded to the questionnaire, mean age 65 years (SD 15) and 70% were women. Worse scores in function, pain, general health and tender joints at baseline increased the risk of being in the most affected group, as measured by HAQ and RAOS 5-18 years after disease onset (p50.000). Conclusion: High levels of pain and worse reports of function at disease onset were risk factors for being in the most disabled tertile of patients after 5-18 years. Pain and function proved to be predictors of the outcome while some measures of inflammation were not. It is important to recognize these patients who may be in need of multidisciplinary treatments already at disease onset. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Functioning, pain, prognostic factors, rheumatoid arthritis
in
Disability and Rehabilitation
volume
37
issue
8
pages
686 - 691
publisher
Taylor & Francis
external identifiers
  • wos:000351435700005
  • scopus:84924721244
ISSN
0963-8288
DOI
10.3109/09638288.2014.939773
language
English
LU publication?
yes
id
00e87749-eee7-430f-8474-7996ca121ab8 (old id 5293880)
date added to LUP
2015-05-04 08:32:51
date last changed
2017-01-01 03:24:08
@article{00e87749-eee7-430f-8474-7996ca121ab8,
  abstract     = {Purpose: Identify factors predictive for severe self-reported disability in patients with rheumatoid arthritis. Methods: Patients (n = 1910) were sent a questionnaire 5-18 years after disease onset. Outcomes were the Health Assessment Questionnaire (HAQ), Rheumatoid Arthritis Outcome Score (RAOS) and physical activity. The tertile of patients most affected by the disease were compared to those less affected. Proposed predictive factors were function, pain, general health, radiographic joint damage, swollen/tender joints and disease activity measures at baseline. Age, gender and disease duration were controlled for in logistic regression analyses. Results: Seventy-three percent (n = 1387) responded to the questionnaire, mean age 65 years (SD 15) and 70% were women. Worse scores in function, pain, general health and tender joints at baseline increased the risk of being in the most affected group, as measured by HAQ and RAOS 5-18 years after disease onset (p50.000). Conclusion: High levels of pain and worse reports of function at disease onset were risk factors for being in the most disabled tertile of patients after 5-18 years. Pain and function proved to be predictors of the outcome while some measures of inflammation were not. It is important to recognize these patients who may be in need of multidisciplinary treatments already at disease onset.},
  author       = {Malm, Karina and Bergman, Stefan and Andersson, Maria and Bremander, Ann},
  issn         = {0963-8288},
  keyword      = {Functioning,pain,prognostic factors,rheumatoid arthritis},
  language     = {eng},
  number       = {8},
  pages        = {686--691},
  publisher    = {Taylor & Francis},
  series       = {Disability and Rehabilitation},
  title        = {Predictors of severe self-reported disability in RA in a long-term follow-up study},
  url          = {http://dx.doi.org/10.3109/09638288.2014.939773},
  volume       = {37},
  year         = {2015},
}