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Solvatochromic fluorescent BODIPY derivative as imaging agent in camptothecin loaded hexosomes for possible theranostic applications

Caltagirone, Claudia ; Arca, Massimiliano ; Falchi, Angela M. ; Lippolis, Vito ; Meli, Valeria ; Monduzzi, Maura ; Nylander, Tommy LU ; Rosa, Antonella ; Schmidt, Judith and Talmon, Yeshayahu , et al. (2015) In RSC Advances 5(30). p.23443-23449
Abstract
We here discuss the potential theranostic nanomedicine application of an innovative formulation consisting of monoolein-based nanoparticles with a two-dimensional hexagonal inner structure stabilized in water using a mixture of PEO132-PPO50-PEO132 block copolymers with and without conjugated folate for targeting. The proposed tumor-cell targeted formulation was shown to be able to simultaneously host the model anticancer drug camptothecin and a pyrene-modified BODIPY fluorophore, based on dynamic light scattering, small-angle X-ray scattering, and cryogenic transmission electron microscopy. The photophysical properties of the fluorophore were studied in solution in various solvents. A marked fluorescent solvatochromism, whose origin was... (More)
We here discuss the potential theranostic nanomedicine application of an innovative formulation consisting of monoolein-based nanoparticles with a two-dimensional hexagonal inner structure stabilized in water using a mixture of PEO132-PPO50-PEO132 block copolymers with and without conjugated folate for targeting. The proposed tumor-cell targeted formulation was shown to be able to simultaneously host the model anticancer drug camptothecin and a pyrene-modified BODIPY fluorophore, based on dynamic light scattering, small-angle X-ray scattering, and cryogenic transmission electron microscopy. The photophysical properties of the fluorophore were studied in solution in various solvents. A marked fluorescent solvatochromism, whose origin was explained by time-dependent density functional theory theoretical calculations, was observed. Fluorescence microscopy showed that HeLa cells readily internalize these nanoparticles, and that the fluorophore localizes within the lipid droplets. In addition, cytotoxicity test revealed that these nanoparticles are not toxic at the concentration used for the imaging analysis. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
RSC Advances
volume
5
issue
30
pages
23443 - 23449
publisher
Royal Society of Chemistry
external identifiers
  • wos:000351235800040
  • scopus:84927803363
ISSN
2046-2069
DOI
10.1039/c5ra01025j
language
English
LU publication?
yes
id
38dafbe6-98d0-4981-b154-5651e168ee68 (old id 5293956)
date added to LUP
2016-04-01 14:22:52
date last changed
2025-04-04 14:11:37
@article{38dafbe6-98d0-4981-b154-5651e168ee68,
  abstract     = {{We here discuss the potential theranostic nanomedicine application of an innovative formulation consisting of monoolein-based nanoparticles with a two-dimensional hexagonal inner structure stabilized in water using a mixture of PEO132-PPO50-PEO132 block copolymers with and without conjugated folate for targeting. The proposed tumor-cell targeted formulation was shown to be able to simultaneously host the model anticancer drug camptothecin and a pyrene-modified BODIPY fluorophore, based on dynamic light scattering, small-angle X-ray scattering, and cryogenic transmission electron microscopy. The photophysical properties of the fluorophore were studied in solution in various solvents. A marked fluorescent solvatochromism, whose origin was explained by time-dependent density functional theory theoretical calculations, was observed. Fluorescence microscopy showed that HeLa cells readily internalize these nanoparticles, and that the fluorophore localizes within the lipid droplets. In addition, cytotoxicity test revealed that these nanoparticles are not toxic at the concentration used for the imaging analysis.}},
  author       = {{Caltagirone, Claudia and Arca, Massimiliano and Falchi, Angela M. and Lippolis, Vito and Meli, Valeria and Monduzzi, Maura and Nylander, Tommy and Rosa, Antonella and Schmidt, Judith and Talmon, Yeshayahu and Murgia, Sergio}},
  issn         = {{2046-2069}},
  language     = {{eng}},
  number       = {{30}},
  pages        = {{23443--23449}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{RSC Advances}},
  title        = {{Solvatochromic fluorescent BODIPY derivative as imaging agent in camptothecin loaded hexosomes for possible theranostic applications}},
  url          = {{http://dx.doi.org/10.1039/c5ra01025j}},
  doi          = {{10.1039/c5ra01025j}},
  volume       = {{5}},
  year         = {{2015}},
}