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Impact of cardiac dysfunction on health-related quality of life in cirrhotic liver transplant candidates

Josefsson, Axel; Fu, Michael; Björnsson, Einar; Castedal, Maria and Kalaitzakis, Evangelos LU (2015) In European Journal of Gastroenterology and Hepathology 27(4). p.393-398
Abstract
Objective Cardiac dysfunction, in particular left ventricular diastolic dysfunction, is common in cirrhosis. We aimed to investigate the impact of cardiac dysfunction on health-related quality of life (QoL) in liver cirrhosis. Materials and methods A total of 88 cirrhotic liver transplant candidates with an available echocardiogram and ECG completed the Short form-36 (SF-36) and Fatigue Impact Scale. In a subgroup of 61 patients, levels of cardiac biomarkers, in particular serum N-terminal pro-brain natriuretic peptide, adiponectin, and high-sensitive troponin T, were also measured. Results Although left ventricular systolic diameter was related to a lower SF-36 physical component summary, neither left ventricular diastolic dysfunction nor... (More)
Objective Cardiac dysfunction, in particular left ventricular diastolic dysfunction, is common in cirrhosis. We aimed to investigate the impact of cardiac dysfunction on health-related quality of life (QoL) in liver cirrhosis. Materials and methods A total of 88 cirrhotic liver transplant candidates with an available echocardiogram and ECG completed the Short form-36 (SF-36) and Fatigue Impact Scale. In a subgroup of 61 patients, levels of cardiac biomarkers, in particular serum N-terminal pro-brain natriuretic peptide, adiponectin, and high-sensitive troponin T, were also measured. Results Although left ventricular systolic diameter was related to a lower SF-36 physical component summary, neither left ventricular diastolic dysfunction nor any other echocardiographic feature was found to be associated with any other SF-36 or Fatigue Impact Scale domain (P>0.05 for all). On linear regression analysis after adjustment for confounders, a prolonged QTc interval was found to be related to a lower SF-36 mental component summary score (beta = -9.7, P = 0.009) and increased physical fatigue (beta = 10.5, P= 0.004). Neither serum N-terminal pro-brain natriuretic peptide, high-sensitivity troponin T, nor adiponectin levels were found to be related to QoL (P> 0.05 for all). Serum adiponectin levels did not differ among patients with versus those without echocardiographic cardiac alterations (P> 0.05 for all). Conclusion A prolonged QTc interval, but not any echocardiographic abnormalities or cardiac biomarkers, seems to be predictive of QoL in cirrhosis. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cirrhotic cardiomyopathy, fatigue, health-related quality of life, left, ventricular diastolic dysfunction, liver cirrhosis, liver, transplantation
in
European Journal of Gastroenterology and Hepathology
volume
27
issue
4
pages
393 - 398
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000350763800006
  • scopus:84924902162
  • pmid:25874511
ISSN
1473-5687
DOI
10.1097/MEG.0000000000000292
language
English
LU publication?
yes
id
b12e875c-f0ae-4d6e-917b-106b40f7cfd3 (old id 5294017)
date added to LUP
2015-05-04 08:32:24
date last changed
2017-01-01 03:22:21
@article{b12e875c-f0ae-4d6e-917b-106b40f7cfd3,
  abstract     = {Objective Cardiac dysfunction, in particular left ventricular diastolic dysfunction, is common in cirrhosis. We aimed to investigate the impact of cardiac dysfunction on health-related quality of life (QoL) in liver cirrhosis. Materials and methods A total of 88 cirrhotic liver transplant candidates with an available echocardiogram and ECG completed the Short form-36 (SF-36) and Fatigue Impact Scale. In a subgroup of 61 patients, levels of cardiac biomarkers, in particular serum N-terminal pro-brain natriuretic peptide, adiponectin, and high-sensitive troponin T, were also measured. Results Although left ventricular systolic diameter was related to a lower SF-36 physical component summary, neither left ventricular diastolic dysfunction nor any other echocardiographic feature was found to be associated with any other SF-36 or Fatigue Impact Scale domain (P>0.05 for all). On linear regression analysis after adjustment for confounders, a prolonged QTc interval was found to be related to a lower SF-36 mental component summary score (beta = -9.7, P = 0.009) and increased physical fatigue (beta = 10.5, P= 0.004). Neither serum N-terminal pro-brain natriuretic peptide, high-sensitivity troponin T, nor adiponectin levels were found to be related to QoL (P> 0.05 for all). Serum adiponectin levels did not differ among patients with versus those without echocardiographic cardiac alterations (P> 0.05 for all). Conclusion A prolonged QTc interval, but not any echocardiographic abnormalities or cardiac biomarkers, seems to be predictive of QoL in cirrhosis. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.},
  author       = {Josefsson, Axel and Fu, Michael and Björnsson, Einar and Castedal, Maria and Kalaitzakis, Evangelos},
  issn         = {1473-5687},
  keyword      = {cirrhotic cardiomyopathy,fatigue,health-related quality of life,left,ventricular diastolic dysfunction,liver cirrhosis,liver,transplantation},
  language     = {eng},
  number       = {4},
  pages        = {393--398},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Gastroenterology and Hepathology},
  title        = {Impact of cardiac dysfunction on health-related quality of life in cirrhotic liver transplant candidates},
  url          = {http://dx.doi.org/10.1097/MEG.0000000000000292},
  volume       = {27},
  year         = {2015},
}