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The Applicability of Mouse Models to the Study of Human Disease

Rydell-Törmänen, Kristina LU and Johnson, Jill R. (2019) In Methods in molecular biology (Clifton, N.J.) 1940. p.3-22
Abstract

The laboratory mouse Mus musculus has long been used as a model organism to test hypotheses and treatments related to understanding the mechanisms of disease in humans; however, for these experiments to be relevant, it is important to know the complex ways in which mice are similar to humans and, crucially, the ways in which they differ. In this chapter, an in-depth analysis of these similarities and differences is provided to allow researchers to use mouse models of human disease and primary cells derived from these animal models under the most appropriate and meaningful conditions.Although there are considerable differences between mice and humans, particularly regarding genetics, physiology, and immunology, a more thorough... (More)

The laboratory mouse Mus musculus has long been used as a model organism to test hypotheses and treatments related to understanding the mechanisms of disease in humans; however, for these experiments to be relevant, it is important to know the complex ways in which mice are similar to humans and, crucially, the ways in which they differ. In this chapter, an in-depth analysis of these similarities and differences is provided to allow researchers to use mouse models of human disease and primary cells derived from these animal models under the most appropriate and meaningful conditions.Although there are considerable differences between mice and humans, particularly regarding genetics, physiology, and immunology, a more thorough understanding of these differences and their effects on the function of the whole organism will provide deeper insights into relevant disease mechanisms and potential drug targets for further clinical investigation. Using specific examples of mouse models of human lung disease, i.e., asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis, this chapter explores the most salient features of mouse models of human disease and provides a full assessment of the advantages and limitations of these models, focusing on the relevance of disease induction and their ability to replicate critical features of human disease pathophysiology and response to treatment. The chapter concludes with a discussion on the future of using mice in medical research with regard to ethical and technological considerations.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Disease, Ethics, Genetics, Immunology, Model, Mouse, Physiology
in
Methods in molecular biology (Clifton, N.J.)
volume
1940
pages
20 pages
publisher
Springer
external identifiers
  • scopus:85061974850
ISSN
1940-6029
DOI
10.1007/978-1-4939-9086-3_1
language
English
LU publication?
yes
id
52a293eb-1c1d-46c3-8b0c-2cbb58bfd4c0
date added to LUP
2019-03-07 14:00:15
date last changed
2019-11-13 05:27:57
@article{52a293eb-1c1d-46c3-8b0c-2cbb58bfd4c0,
  abstract     = {<p>The laboratory mouse Mus musculus has long been used as a model organism to test hypotheses and treatments related to understanding the mechanisms of disease in humans; however, for these experiments to be relevant, it is important to know the complex ways in which mice are similar to humans and, crucially, the ways in which they differ. In this chapter, an in-depth analysis of these similarities and differences is provided to allow researchers to use mouse models of human disease and primary cells derived from these animal models under the most appropriate and meaningful conditions.Although there are considerable differences between mice and humans, particularly regarding genetics, physiology, and immunology, a more thorough understanding of these differences and their effects on the function of the whole organism will provide deeper insights into relevant disease mechanisms and potential drug targets for further clinical investigation. Using specific examples of mouse models of human lung disease, i.e., asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis, this chapter explores the most salient features of mouse models of human disease and provides a full assessment of the advantages and limitations of these models, focusing on the relevance of disease induction and their ability to replicate critical features of human disease pathophysiology and response to treatment. The chapter concludes with a discussion on the future of using mice in medical research with regard to ethical and technological considerations.</p>},
  author       = {Rydell-Törmänen, Kristina and Johnson, Jill R.},
  issn         = {1940-6029},
  keyword      = {Disease,Ethics,Genetics,Immunology,Model,Mouse,Physiology},
  language     = {eng},
  pages        = {3--22},
  publisher    = {Springer},
  series       = {Methods in molecular biology (Clifton, N.J.)},
  title        = {The Applicability of Mouse Models to the Study of Human Disease},
  url          = {http://dx.doi.org/10.1007/978-1-4939-9086-3_1},
  volume       = {1940},
  year         = {2019},
}