Bacterial growth and antimicrobial resistance in urinary Escherichia coli isolates among men with lower UTI in Swedish primary healthcare: retrospective data over a 4 year period
Kornfält Isberg, Helena LU ; Sundqvist, Martin ; Melander, Eva LU ; Beckman, Anders LU
and Hedin, Katarina
LU
(2024)
In JAC - Antimicrobial Resistance
7(1).
- Abstract
- Background: Escherichia coli, the most common bacterium causing urinary tract infections (UTIs), is increasingly reported as resistant to multiple antibiotics. Swedish surveillance data from hospital and primary health care (PHC) report a 17%-19% prevalence of resistance to ciprofloxacin in E. coli from urine cultures in men over 20 years of age. Surveillance data may include nosocomial infections. However, few studies have described resistance in E. coli in men with community-acquired UTI in PHC. We aimed to describe the microbiological results, including antibiotic resistance in E. coli, in men with lower UTI (LUTI) attending PHC.
Methods: In this retrospective study based on information from electronic medical records, we... (More) - Background: Escherichia coli, the most common bacterium causing urinary tract infections (UTIs), is increasingly reported as resistant to multiple antibiotics. Swedish surveillance data from hospital and primary health care (PHC) report a 17%-19% prevalence of resistance to ciprofloxacin in E. coli from urine cultures in men over 20 years of age. Surveillance data may include nosocomial infections. However, few studies have described resistance in E. coli in men with community-acquired UTI in PHC. We aimed to describe the microbiological results, including antibiotic resistance in E. coli, in men with lower UTI (LUTI) attending PHC.
Methods: In this retrospective study based on information from electronic medical records, we included patients from 289 PHC centres. For all men aged 18-79 years diagnosed with LUTI in PHC from January 2012 to December 2015, we extracted data on age, UTI diagnosis and results from urine cultures.
Results: A total of 17 987 episodes of lower UTI were identified. E. coli was detected in 62% of positive cultures and 63% of detected E. coli isolates were susceptible to all tested antimicrobials. Resistance in E. coli to the first-choice antibiotics pivmecillinam and nitrofurantoin were 2% and 1%, respectively. Resistance to ciprofloxacin was 9%, and to trimethoprim it was 17%.
Conclusions: Resistance levels for ciprofloxacin in E. coli among men with LUTI in PHC were lower than in surveillance data. The results of this study point to the importance of surveillance of resistance in urine samples from patients with LUTI in PHC in order to choose the right empirical antibiotic treatment.
(Less) - Abstract (Swedish)
- Background: Escherichia coli, the most common bacterium causing urinary tract infections (UTIs), is increasingly
reported as resistant to multiple antibiotics. Swedish surveillance data from hospital and primary health care
(PHC) report a 17%–19% prevalence of resistance to ciprofloxacin in E. coli from urine cultures in men over
20 years of age. Surveillance data may include nosocomial infections. However, few studies have described resistance in E. coli in men with community-acquired UTI in PHC. We aimed to describe the microbiological results,
including antibiotic resistance in E. coli, in men with lower UTI (LUTI) attending PHC.
Methods: In this retrospective study based on information from electronic medical... (More) - Background: Escherichia coli, the most common bacterium causing urinary tract infections (UTIs), is increasingly
reported as resistant to multiple antibiotics. Swedish surveillance data from hospital and primary health care
(PHC) report a 17%–19% prevalence of resistance to ciprofloxacin in E. coli from urine cultures in men over
20 years of age. Surveillance data may include nosocomial infections. However, few studies have described resistance in E. coli in men with community-acquired UTI in PHC. We aimed to describe the microbiological results,
including antibiotic resistance in E. coli, in men with lower UTI (LUTI) attending PHC.
Methods: In this retrospective study based on information from electronic medical records, we included patients
from 289 PHC centres. For all men aged 18–79 years diagnosed with LUTI in PHC from January 2012 to
December 2015, we extracted data on age, UTI diagnosis and results from urine cultures.
Results: A total of 17 987 episodes of lower UTI were identified. E. coli was detected in 62% of positive cultures
and 63% of detected E. coli isolates were susceptible to all tested antimicrobials. Resistance in E. coli to the firstchoice antibiotics pivmecillinam and nitrofurantoin were 2% and 1%, respectively. Resistance to ciprofloxacin
was 9%, and to trimethoprim it was 17%.
Conclusions: Resistance levels for ciprofloxacin in E. coli among men with LUTI in PHC were lower than in surveillance data. The results of this study point to the importance of surveillance of resistance in urine samples from
patients with LUTI in PHC in order to choose the right empirical antibiotic treatment. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/52d78ad9-0896-4449-b60e-72fdca562994
- author
- Kornfält Isberg, Helena
LU
; Sundqvist, Martin
; Melander, Eva
LU
; Beckman, Anders
LU
and Hedin, Katarina
LU
- organization
- alternative title
- Växt av bakterier och antibiotikaresistens bland Escherichia coli isolat hos män med akut cystit i svensk primärvård: retrospektiv data över en fyraårsperiod.
- publishing date
- 2024-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- JAC - Antimicrobial Resistance
- volume
- 7
- issue
- 1
- article number
- dlae214
- publisher
- Oxford University Press
- external identifiers
-
- pmid:39734489
- scopus:85216124989
- ISSN
- 2632-1823
- DOI
- 10.1093/jacamr/dlae214
- language
- English
- LU publication?
- yes
- id
- 52d78ad9-0896-4449-b60e-72fdca562994
- date added to LUP
- 2025-01-19 12:07:26
- date last changed
- 2025-04-04 15:06:43
@article{52d78ad9-0896-4449-b60e-72fdca562994,
abstract = {{Background: Escherichia coli, the most common bacterium causing urinary tract infections (UTIs), is increasingly reported as resistant to multiple antibiotics. Swedish surveillance data from hospital and primary health care (PHC) report a 17%-19% prevalence of resistance to ciprofloxacin in E. coli from urine cultures in men over 20 years of age. Surveillance data may include nosocomial infections. However, few studies have described resistance in E. coli in men with community-acquired UTI in PHC. We aimed to describe the microbiological results, including antibiotic resistance in E. coli, in men with lower UTI (LUTI) attending PHC.<br/><br/>Methods: In this retrospective study based on information from electronic medical records, we included patients from 289 PHC centres. For all men aged 18-79 years diagnosed with LUTI in PHC from January 2012 to December 2015, we extracted data on age, UTI diagnosis and results from urine cultures.<br/><br/>Results: A total of 17 987 episodes of lower UTI were identified. E. coli was detected in 62% of positive cultures and 63% of detected E. coli isolates were susceptible to all tested antimicrobials. Resistance in E. coli to the first-choice antibiotics pivmecillinam and nitrofurantoin were 2% and 1%, respectively. Resistance to ciprofloxacin was 9%, and to trimethoprim it was 17%.<br/><br/>Conclusions: Resistance levels for ciprofloxacin in E. coli among men with LUTI in PHC were lower than in surveillance data. The results of this study point to the importance of surveillance of resistance in urine samples from patients with LUTI in PHC in order to choose the right empirical antibiotic treatment.<br/>}},
author = {{Kornfält Isberg, Helena and Sundqvist, Martin and Melander, Eva and Beckman, Anders and Hedin, Katarina}},
issn = {{2632-1823}},
language = {{eng}},
number = {{1}},
publisher = {{Oxford University Press}},
series = {{JAC - Antimicrobial Resistance}},
title = {{Bacterial growth and antimicrobial resistance in urinary Escherichia coli isolates among men with lower UTI in Swedish primary healthcare: retrospective data over a 4 year period}},
url = {{http://dx.doi.org/10.1093/jacamr/dlae214}},
doi = {{10.1093/jacamr/dlae214}},
volume = {{7}},
year = {{2024}},
}