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Rim Sign in Breast Lesions on Diffusion-Weighted Magnetic Resonance Imaging: Diagnostic Accuracy and Clinical Usefulness

Kang, Bong Joo; Lipson, Jafi Alyssa; Planey, Katie RoseMary; Zackrisson, Sophia LU ; Ikeda, Debra M.; Kao, Jennifer; Pal, Sunita; Moran, Catherine J. and Daniel, Bruce Lewis (2015) In Journal of Magnetic Resonance Imaging 41(3). p.616-623
Abstract
PurposeTo investigate the diagnostic accuracy and clinical usefulness of the rim sign in breast lesions observed in diffusion-weighted magnetic resonance imaging (DWI). Materials and MethodsThe magnetic resonance imaging (MRI) findings of 98 pathologically confirmed lesions (62 malignant and 36 benign) in 84 patients were included. Five breast radiologists were asked to independently review the breast MRI results, to grade the degree of high peripheral signal, the rim sign, in the DWI, and to confirm the mean apparent diffusion coefficient (ADC(mean)) values. We analyzed the diagnostic accuracy and compared the consensus (when 4 of 5 independent reviewers agreed) results of the rim sign with the ADC(mean) values. Additionally, we evaluated... (More)
PurposeTo investigate the diagnostic accuracy and clinical usefulness of the rim sign in breast lesions observed in diffusion-weighted magnetic resonance imaging (DWI). Materials and MethodsThe magnetic resonance imaging (MRI) findings of 98 pathologically confirmed lesions (62 malignant and 36 benign) in 84 patients were included. Five breast radiologists were asked to independently review the breast MRI results, to grade the degree of high peripheral signal, the rim sign, in the DWI, and to confirm the mean apparent diffusion coefficient (ADC(mean)) values. We analyzed the diagnostic accuracy and compared the consensus (when 4 of 5 independent reviewers agreed) results of the rim sign with the ADC(mean) values. Additionally, we evaluated the correlation between the dynamic contrast-enhanced (DCE)-MRI morphologic appearance and DWI rim sign. ResultsAccording to the consensus results, the rim sign in DWI was observed on 59.7% of malignant lesions and 19.4% of benign lesions. The sensitivity, specificity, and area under the curve (AUC) value for the rim sign in DWI were 59.7%, 80.6%, and 0.701, respectively. The sensitivity, specificity, and AUC value for the ADC(mean) value (criteria 1.46 x 10(-3) mm(2)/sec) were 82.3%, 63.9%, and 0.731, respectively. Based on consensus, no correlation was observed between the DCE-MRI and DWI rim signs. ConclusionIn DWI, a high-signal rim is a valuable morphological feature for improving specificity in DWI. J. Magn. Reson. Imaging 2015;41:616-623. (c) 2014 Wiley Periodicals, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breast cancer, magnetic resonance imaging, diffusion-weighted image
in
Journal of Magnetic Resonance Imaging
volume
41
issue
3
pages
616 - 623
publisher
John Wiley & Sons
external identifiers
  • wos:000349967700006
  • scopus:84923129270
ISSN
1522-2586
DOI
10.1002/jmri.24617
language
English
LU publication?
yes
id
73ab1277-b920-4ccb-a69b-1147dcb15fe0 (old id 5305164)
date added to LUP
2015-05-04 08:39:24
date last changed
2017-06-11 03:17:24
@article{73ab1277-b920-4ccb-a69b-1147dcb15fe0,
  abstract     = {PurposeTo investigate the diagnostic accuracy and clinical usefulness of the rim sign in breast lesions observed in diffusion-weighted magnetic resonance imaging (DWI). Materials and MethodsThe magnetic resonance imaging (MRI) findings of 98 pathologically confirmed lesions (62 malignant and 36 benign) in 84 patients were included. Five breast radiologists were asked to independently review the breast MRI results, to grade the degree of high peripheral signal, the rim sign, in the DWI, and to confirm the mean apparent diffusion coefficient (ADC(mean)) values. We analyzed the diagnostic accuracy and compared the consensus (when 4 of 5 independent reviewers agreed) results of the rim sign with the ADC(mean) values. Additionally, we evaluated the correlation between the dynamic contrast-enhanced (DCE)-MRI morphologic appearance and DWI rim sign. ResultsAccording to the consensus results, the rim sign in DWI was observed on 59.7% of malignant lesions and 19.4% of benign lesions. The sensitivity, specificity, and area under the curve (AUC) value for the rim sign in DWI were 59.7%, 80.6%, and 0.701, respectively. The sensitivity, specificity, and AUC value for the ADC(mean) value (criteria 1.46 x 10(-3) mm(2)/sec) were 82.3%, 63.9%, and 0.731, respectively. Based on consensus, no correlation was observed between the DCE-MRI and DWI rim signs. ConclusionIn DWI, a high-signal rim is a valuable morphological feature for improving specificity in DWI. J. Magn. Reson. Imaging 2015;41:616-623. (c) 2014 Wiley Periodicals, Inc.},
  author       = {Kang, Bong Joo and Lipson, Jafi Alyssa and Planey, Katie RoseMary and Zackrisson, Sophia and Ikeda, Debra M. and Kao, Jennifer and Pal, Sunita and Moran, Catherine J. and Daniel, Bruce Lewis},
  issn         = {1522-2586},
  keyword      = {breast cancer,magnetic resonance imaging,diffusion-weighted image},
  language     = {eng},
  number       = {3},
  pages        = {616--623},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Magnetic Resonance Imaging},
  title        = {Rim Sign in Breast Lesions on Diffusion-Weighted Magnetic Resonance Imaging: Diagnostic Accuracy and Clinical Usefulness},
  url          = {http://dx.doi.org/10.1002/jmri.24617},
  volume       = {41},
  year         = {2015},
}