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Genetic modification of ALAD and VDR on lead-induced impairment of hearing in children.

Pawlas, Natalia; Broberg Palmgren, Karin LU ; Olewińska, Elżbieta; Kozłowska, Agnieszka; Skerfving, Staffan LU and Pawlas, Krystyna (2015) In Environmental Toxicology and Pharmacology 39(3). p.1091-1098
Abstract
Polymorphisms in the δ-aminolevulinic acid dehydratase (ALAD) and the vitamin D receptor (VDR) genes may modify lead metabolism and neurotoxicity. Two cohorts of children were examined for hearing [pure-tone audiometry (PTA), brain stem auditory evoked potentials (BAEP)], acoustic otoemission (transient emission evoked by a click) and blood-lead concentrations (B-Pb). The children were genotyped for polymorphisms in ALAD and VDR. The median B-Pbs were 55 and 36μg/L in the two cohorts (merged cohort 45μg/L). B-Pb was significantly associated with impaired hearing when tested with PTA (correlation coefficient rS=0.12; P<0.01), BAEP (rS=0.18; P<0.001) and otoemission (rS=-0.24; P<0.001). VDR significantly modified the lead-induced... (More)
Polymorphisms in the δ-aminolevulinic acid dehydratase (ALAD) and the vitamin D receptor (VDR) genes may modify lead metabolism and neurotoxicity. Two cohorts of children were examined for hearing [pure-tone audiometry (PTA), brain stem auditory evoked potentials (BAEP)], acoustic otoemission (transient emission evoked by a click) and blood-lead concentrations (B-Pb). The children were genotyped for polymorphisms in ALAD and VDR. The median B-Pbs were 55 and 36μg/L in the two cohorts (merged cohort 45μg/L). B-Pb was significantly associated with impaired hearing when tested with PTA (correlation coefficient rS=0.12; P<0.01), BAEP (rS=0.18; P<0.001) and otoemission (rS=-0.24; P<0.001). VDR significantly modified the lead-induced effects on PTA. Carriers of the VDR alleles BsmI B, VDR TaqI t and VDR FokI F showed greater toxic effects on PTA, compared to BsmI bb, VDR TaqI TT and VDR FokI ff carriers. No significant interaction was found for ALAD. Lead impairs hearing functions in the route from the cochlea to the brain stem at low-level exposure, and polymorphisms in VDR significantly modify these effects. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental Toxicology and Pharmacology
volume
39
issue
3
pages
1091 - 1098
publisher
Elsevier
external identifiers
  • pmid:25899472
  • wos:000357242500012
  • scopus:84928019927
ISSN
1872-7077
DOI
10.1016/j.etap.2015.03.008
language
English
LU publication?
yes
id
0752aa43-bae3-4a56-a460-2a88f1c1fecd (old id 5340989)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25899472?dopt=Abstract
date added to LUP
2015-05-02 19:38:33
date last changed
2017-01-01 03:14:45
@article{0752aa43-bae3-4a56-a460-2a88f1c1fecd,
  abstract     = {Polymorphisms in the δ-aminolevulinic acid dehydratase (ALAD) and the vitamin D receptor (VDR) genes may modify lead metabolism and neurotoxicity. Two cohorts of children were examined for hearing [pure-tone audiometry (PTA), brain stem auditory evoked potentials (BAEP)], acoustic otoemission (transient emission evoked by a click) and blood-lead concentrations (B-Pb). The children were genotyped for polymorphisms in ALAD and VDR. The median B-Pbs were 55 and 36μg/L in the two cohorts (merged cohort 45μg/L). B-Pb was significantly associated with impaired hearing when tested with PTA (correlation coefficient rS=0.12; P&lt;0.01), BAEP (rS=0.18; P&lt;0.001) and otoemission (rS=-0.24; P&lt;0.001). VDR significantly modified the lead-induced effects on PTA. Carriers of the VDR alleles BsmI B, VDR TaqI t and VDR FokI F showed greater toxic effects on PTA, compared to BsmI bb, VDR TaqI TT and VDR FokI ff carriers. No significant interaction was found for ALAD. Lead impairs hearing functions in the route from the cochlea to the brain stem at low-level exposure, and polymorphisms in VDR significantly modify these effects.},
  author       = {Pawlas, Natalia and Broberg Palmgren, Karin and Olewińska, Elżbieta and Kozłowska, Agnieszka and Skerfving, Staffan and Pawlas, Krystyna},
  issn         = {1872-7077},
  language     = {eng},
  number       = {3},
  pages        = {1091--1098},
  publisher    = {Elsevier},
  series       = {Environmental Toxicology and Pharmacology},
  title        = {Genetic modification of ALAD and VDR on lead-induced impairment of hearing in children.},
  url          = {http://dx.doi.org/10.1016/j.etap.2015.03.008},
  volume       = {39},
  year         = {2015},
}