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DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells.

Nordström, Lena; Andersson, Elin; Kuci, Venera; Gustavsson, Elin; Holm, Karolina LU ; Ringnér, Markus LU ; Guldberg, Per and Ek, Sara (2015) In BMC Cancer 15(1).
Abstract
The neural transcription factor SOX11 is present at specific stages during embryo development with a very restricted expression in adult tissue, indicating precise regulation of transcription. SOX11 is strongly up-regulated in some malignancies and have a functional role in tumorgenesis. With the aim to explore differences in epigenetic regulation of SOX11 expression in normal versus neoplastic cells, we investigated methylation and histone modifications related to the SOX11 promoter and the possibility to induce re-expression using histone deacetylase (HDAC) or EZH2 inhibitors.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Cancer
volume
15
issue
1
publisher
BioMed Central
external identifiers
  • pmid:25880212
  • wos:000353203900001
  • scopus:84928014401
ISSN
1471-2407
DOI
10.1186/s12885-015-1208-y
language
English
LU publication?
yes
id
fcaab97a-bad7-42cd-bc7f-e57809878be3 (old id 5341697)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25880212?dopt=Abstract
date added to LUP
2015-05-05 18:08:58
date last changed
2017-11-12 03:35:39
@article{fcaab97a-bad7-42cd-bc7f-e57809878be3,
  abstract     = {The neural transcription factor SOX11 is present at specific stages during embryo development with a very restricted expression in adult tissue, indicating precise regulation of transcription. SOX11 is strongly up-regulated in some malignancies and have a functional role in tumorgenesis. With the aim to explore differences in epigenetic regulation of SOX11 expression in normal versus neoplastic cells, we investigated methylation and histone modifications related to the SOX11 promoter and the possibility to induce re-expression using histone deacetylase (HDAC) or EZH2 inhibitors.},
  articleno    = {273},
  author       = {Nordström, Lena and Andersson, Elin and Kuci, Venera and Gustavsson, Elin and Holm, Karolina and Ringnér, Markus and Guldberg, Per and Ek, Sara},
  issn         = {1471-2407},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {BMC Cancer},
  title        = {DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells.},
  url          = {http://dx.doi.org/10.1186/s12885-015-1208-y},
  volume       = {15},
  year         = {2015},
}