Advanced

Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use.

Kraus, V B; Blanco, F J; Englund, Martin LU ; Karsdal, M A and Lohmander, Stefan LU (2015) In Osteoarthritis and Cartilage 23(8). p.1233-1241
Abstract
Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1) To stimulate use of standardized nomenclature for OA that could serve as building blocks for describing OA and defining OA phenotypes, in short to provide unifying disease concepts for a heterogeneous disorder; and (2) To stimulate establishment of ROAD (Risk of OA Development) and ROAP (Risk of OA Progression) tools analogous to the FRAX™ instrument for predicting risk of fracture in osteoporosis; and (3) To stimulate formulation of tools for identifying disease in its early preradiographic and/or molecular stages - REDI (Reliable Early Disease Identification). Consensus around more sensitive and specific diagnostic criteria for OA could spur development of... (More)
Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1) To stimulate use of standardized nomenclature for OA that could serve as building blocks for describing OA and defining OA phenotypes, in short to provide unifying disease concepts for a heterogeneous disorder; and (2) To stimulate establishment of ROAD (Risk of OA Development) and ROAP (Risk of OA Progression) tools analogous to the FRAX™ instrument for predicting risk of fracture in osteoporosis; and (3) To stimulate formulation of tools for identifying disease in its early preradiographic and/or molecular stages - REDI (Reliable Early Disease Identification). Consensus around more sensitive and specific diagnostic criteria for OA could spur development of disease modifying therapies for this entity that has proved so recalcitrant to date. We fully acknowledge that as we move forward, we expect to develop more sophisticated definitions, terminology and tools. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Osteoarthritis and Cartilage
volume
23
issue
8
pages
1233 - 1241
publisher
Elsevier
external identifiers
  • pmid:25865392
  • wos:000358434600002
  • scopus:84938216409
ISSN
1063-4584
DOI
10.1016/j.joca.2015.03.036
language
English
LU publication?
yes
id
a4293fce-6178-4df7-b695-3677f9247f02 (old id 5342072)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25865392?dopt=Abstract
date added to LUP
2015-05-06 11:23:53
date last changed
2017-10-22 03:20:31
@article{a4293fce-6178-4df7-b695-3677f9247f02,
  abstract     = {Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1) To stimulate use of standardized nomenclature for OA that could serve as building blocks for describing OA and defining OA phenotypes, in short to provide unifying disease concepts for a heterogeneous disorder; and (2) To stimulate establishment of ROAD (Risk of OA Development) and ROAP (Risk of OA Progression) tools analogous to the FRAX™ instrument for predicting risk of fracture in osteoporosis; and (3) To stimulate formulation of tools for identifying disease in its early preradiographic and/or molecular stages - REDI (Reliable Early Disease Identification). Consensus around more sensitive and specific diagnostic criteria for OA could spur development of disease modifying therapies for this entity that has proved so recalcitrant to date. We fully acknowledge that as we move forward, we expect to develop more sophisticated definitions, terminology and tools.},
  author       = {Kraus, V B and Blanco, F J and Englund, Martin and Karsdal, M A and Lohmander, Stefan},
  issn         = {1063-4584},
  language     = {eng},
  number       = {8},
  pages        = {1233--1241},
  publisher    = {Elsevier},
  series       = {Osteoarthritis and Cartilage},
  title        = {Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use.},
  url          = {http://dx.doi.org/10.1016/j.joca.2015.03.036},
  volume       = {23},
  year         = {2015},
}