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Distinct metabolomic signatures are associated with longevity in humans.

Cheng, Susan; Larson, Martin G; McCabe, Elizabeth L; Murabito, Joanne M; Rhee, Eugene P; Ho, Jennifer E; Jacques, Paul F; Ghorbani, Anahita; Magnusson, Martin LU and Souza, Amanda L, et al. (2015) In Nature Communications 6.
Abstract
Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to longevity in a large cohort of men and women followed for up to 20 years. We find that, higher concentrations of the citric acid cycle intermediate, isocitrate, and the bile acid, taurocholate, are associated with lower odds of longevity, defined as attaining 80 years of age. Higher concentrations of isocitrate, but not taurocholate, are also associated with worse cardiovascular health at baseline, as well as risk of future cardiovascular disease and death. None of the metabolites identified are associated with cancer risk.... (More)
Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to longevity in a large cohort of men and women followed for up to 20 years. We find that, higher concentrations of the citric acid cycle intermediate, isocitrate, and the bile acid, taurocholate, are associated with lower odds of longevity, defined as attaining 80 years of age. Higher concentrations of isocitrate, but not taurocholate, are also associated with worse cardiovascular health at baseline, as well as risk of future cardiovascular disease and death. None of the metabolites identified are associated with cancer risk. Our findings suggest that some, but not all, metabolic pathways related to human longevity are linked to the risk of common causes of death. (Less)
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Nature Communications
volume
6
publisher
Nature Publishing Group
external identifiers
  • pmid:25864806
  • wos:000353702500031
  • scopus:84927779873
ISSN
2041-1723
DOI
10.1038/ncomms7791
language
English
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yes
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1a597704-31fb-47d1-9fc2-52ba78b43e04 (old id 5342087)
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http://www.ncbi.nlm.nih.gov/pubmed/25864806?dopt=Abstract
date added to LUP
2015-05-06 11:28:25
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2017-11-06 13:04:44
@article{1a597704-31fb-47d1-9fc2-52ba78b43e04,
  abstract     = {Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to longevity in a large cohort of men and women followed for up to 20 years. We find that, higher concentrations of the citric acid cycle intermediate, isocitrate, and the bile acid, taurocholate, are associated with lower odds of longevity, defined as attaining 80 years of age. Higher concentrations of isocitrate, but not taurocholate, are also associated with worse cardiovascular health at baseline, as well as risk of future cardiovascular disease and death. None of the metabolites identified are associated with cancer risk. Our findings suggest that some, but not all, metabolic pathways related to human longevity are linked to the risk of common causes of death.},
  articleno    = {6791},
  author       = {Cheng, Susan and Larson, Martin G and McCabe, Elizabeth L and Murabito, Joanne M and Rhee, Eugene P and Ho, Jennifer E and Jacques, Paul F and Ghorbani, Anahita and Magnusson, Martin and Souza, Amanda L and Deik, Amy A and Pierce, Kerry A and Bullock, Kevin and O'Donnell, Christopher J and Melander, Olle and Clish, Clary B and Vasan, Ramachandran S and Gerszten, Robert E and Wang, Thomas J},
  issn         = {2041-1723},
  language     = {eng},
  publisher    = {Nature Publishing Group},
  series       = {Nature Communications},
  title        = {Distinct metabolomic signatures are associated with longevity in humans.},
  url          = {http://dx.doi.org/10.1038/ncomms7791},
  volume       = {6},
  year         = {2015},
}