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Evidence for sexual conflict over major histocompatibility complex diversity in a wild songbird

Roved, Jacob LU ; Hansson, Bengt LU ; Tarka, Maja LU ; Hasselquist, Dennis LU and Westerdahl, Helena LU (2018) In Proceedings of the Royal Society B: Biological Sciences 285(1884).
Abstract

Sex differences in parasite load and immune responses are found across a wide range of animals, with females generally having lower parasite loads and stronger immune responses than males. Intrigued by these general patterns, we investigated if there was any sign of sex-specific selection on an essential component of adaptive immunity that is known to affect fitness, the major histocompatibility complex class I (MHC-I) genes, in a 20-year study of great reed warblers. Our analyses on fitness related to MHC-I diversity showed a highly significant interaction between MHC-I diversity and sex, where males with higher, and females with lower, MHC-I diversity were more successful in recruiting offspring. Importantly, mean MHC-I diversity did... (More)

Sex differences in parasite load and immune responses are found across a wide range of animals, with females generally having lower parasite loads and stronger immune responses than males. Intrigued by these general patterns, we investigated if there was any sign of sex-specific selection on an essential component of adaptive immunity that is known to affect fitness, the major histocompatibility complex class I (MHC-I) genes, in a 20-year study of great reed warblers. Our analyses on fitness related to MHC-I diversity showed a highly significant interaction between MHC-I diversity and sex, where males with higher, and females with lower, MHC-I diversity were more successful in recruiting offspring. Importantly, mean MHC-I diversity did not differ between males and females, and consequently neither sex reached its MHC-I fitness optimum. Thus, there is an unresolved genetic sexual conflict over MHC-I diversity in great reed warblers. Selection from pathogens is known to maintain MHC diversity, but previous theory ignores that the immune environments are considerably different in males and females. Our results suggest that sexually antagonistic selection is an important, previously neglected, force in the evolution of vertebrate adaptive immunity, and have implications for evolutionary understanding of costs of immune responses and autoimmune diseases.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Cost of immune responses, Great reed warbler, Immunopathology, Major histocompatibility complex, MHC diversity, Sexually antagonistic selection
in
Proceedings of the Royal Society B: Biological Sciences
volume
285
issue
1884
publisher
Royal Society
external identifiers
  • scopus:85052624370
ISSN
0962-8452
DOI
10.1098/rspb.2018.0841
language
English
LU publication?
yes
id
535c7671-7551-44b2-9f56-5af6dac05698
date added to LUP
2018-10-01 16:21:35
date last changed
2019-02-25 17:36:25
@article{535c7671-7551-44b2-9f56-5af6dac05698,
  abstract     = {<p>Sex differences in parasite load and immune responses are found across a wide range of animals, with females generally having lower parasite loads and stronger immune responses than males. Intrigued by these general patterns, we investigated if there was any sign of sex-specific selection on an essential component of adaptive immunity that is known to affect fitness, the major histocompatibility complex class I (MHC-I) genes, in a 20-year study of great reed warblers. Our analyses on fitness related to MHC-I diversity showed a highly significant interaction between MHC-I diversity and sex, where males with higher, and females with lower, MHC-I diversity were more successful in recruiting offspring. Importantly, mean MHC-I diversity did not differ between males and females, and consequently neither sex reached its MHC-I fitness optimum. Thus, there is an unresolved genetic sexual conflict over MHC-I diversity in great reed warblers. Selection from pathogens is known to maintain MHC diversity, but previous theory ignores that the immune environments are considerably different in males and females. Our results suggest that sexually antagonistic selection is an important, previously neglected, force in the evolution of vertebrate adaptive immunity, and have implications for evolutionary understanding of costs of immune responses and autoimmune diseases.</p>},
  articleno    = {20180841},
  author       = {Roved, Jacob and Hansson, Bengt and Tarka, Maja and Hasselquist, Dennis and Westerdahl, Helena},
  issn         = {0962-8452},
  keyword      = {Cost of immune responses,Great reed warbler,Immunopathology,Major histocompatibility complex,MHC diversity,Sexually antagonistic selection},
  language     = {eng},
  month        = {08},
  number       = {1884},
  publisher    = {Royal Society},
  series       = {Proceedings of the Royal Society B: Biological Sciences},
  title        = {Evidence for sexual conflict over major histocompatibility complex diversity in a wild songbird},
  url          = {http://dx.doi.org/10.1098/rspb.2018.0841},
  volume       = {285},
  year         = {2018},
}