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Cubosome formulations stabilized by a dansyl-conjugated block copolymer for possible nanomedicine applications.

Murgia, Sergio; Falchi, Angela Maria; Meli, Valeria; Schillén, Karin LU ; Lippolis, Vito; Monduzzi, Maura; Rosa, Antonella; Schmidt, Judith; Talmon, Yeshayahu and Bizzarri, Ranieri, et al. (2015) In Colloids and Surfaces B: Biointerfaces 129. p.87-94
Abstract
We present here an innovative, fluorescent, monoolein-based cubosome dispersion. Rather than embedded within the monoolein palisade, the fluorescent imaging agent, namely dansyl, was conjugated to the terminal ethylene oxide moieties of the block copolymer Pluronic F108. We discuss the physicochemical and photophysical properties of this fluorescent Pluronic and of a cubosome formulation stabilized by a mixture of dansyl-conjugated and non-conjugated Pluronic, also including an anticancer drug (quercetin). Furthermore, we performed biocompatibility tests against HeLa cells to assess internalization and cytotoxicity features of this nanoparticles aqueous dispersion. Cryo-TEM, SAXS, and DLS analysis, proved the bicontinuous cubic inner... (More)
We present here an innovative, fluorescent, monoolein-based cubosome dispersion. Rather than embedded within the monoolein palisade, the fluorescent imaging agent, namely dansyl, was conjugated to the terminal ethylene oxide moieties of the block copolymer Pluronic F108. We discuss the physicochemical and photophysical properties of this fluorescent Pluronic and of a cubosome formulation stabilized by a mixture of dansyl-conjugated and non-conjugated Pluronic, also including an anticancer drug (quercetin). Furthermore, we performed biocompatibility tests against HeLa cells to assess internalization and cytotoxicity features of this nanoparticles aqueous dispersion. Cryo-TEM, SAXS, and DLS analysis, proved the bicontinuous cubic inner nanostructure and the morphology of this fluorescent cubosome dispersion, while photophysical measurements and biocompatibility results basically validate their potential use for theranostic nanomedicine applications. (Less)
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type
Contribution to journal
publication status
published
subject
in
Colloids and Surfaces B: Biointerfaces
volume
129
pages
87 - 94
publisher
Elsevier
external identifiers
  • pmid:25829131
  • wos:000355356200012
  • scopus:84925651659
ISSN
1873-4367
DOI
10.1016/j.colsurfb.2015.03.025
language
English
LU publication?
yes
id
0b7f7fb3-345a-4a10-9f0c-3d76b16ce394 (old id 5360597)
date added to LUP
2015-04-30 09:14:27
date last changed
2017-07-09 03:09:59
@article{0b7f7fb3-345a-4a10-9f0c-3d76b16ce394,
  abstract     = {We present here an innovative, fluorescent, monoolein-based cubosome dispersion. Rather than embedded within the monoolein palisade, the fluorescent imaging agent, namely dansyl, was conjugated to the terminal ethylene oxide moieties of the block copolymer Pluronic F108. We discuss the physicochemical and photophysical properties of this fluorescent Pluronic and of a cubosome formulation stabilized by a mixture of dansyl-conjugated and non-conjugated Pluronic, also including an anticancer drug (quercetin). Furthermore, we performed biocompatibility tests against HeLa cells to assess internalization and cytotoxicity features of this nanoparticles aqueous dispersion. Cryo-TEM, SAXS, and DLS analysis, proved the bicontinuous cubic inner nanostructure and the morphology of this fluorescent cubosome dispersion, while photophysical measurements and biocompatibility results basically validate their potential use for theranostic nanomedicine applications.},
  author       = {Murgia, Sergio and Falchi, Angela Maria and Meli, Valeria and Schillén, Karin and Lippolis, Vito and Monduzzi, Maura and Rosa, Antonella and Schmidt, Judith and Talmon, Yeshayahu and Bizzarri, Ranieri and Caltagirone, Claudia},
  issn         = {1873-4367},
  language     = {eng},
  pages        = {87--94},
  publisher    = {Elsevier},
  series       = {Colloids and Surfaces B: Biointerfaces},
  title        = {Cubosome formulations stabilized by a dansyl-conjugated block copolymer for possible nanomedicine applications.},
  url          = {http://dx.doi.org/10.1016/j.colsurfb.2015.03.025},
  volume       = {129},
  year         = {2015},
}