Advanced

The genetics of diabetic complications.

Ahlqvist, Emma LU ; van Zuydam, Natalie R; Groop, Leif LU and McCarthy, Mark I (2015) In Nature Reviews Nephrology 11(5). p.277-287
Abstract
The rising global prevalence of diabetes mellitus is accompanied by an increasing burden of morbidity and mortality that is attributable to the complications of chronic hyperglycaemia. These complications include blindness, renal failure and cardiovascular disease. Current therapeutic options for chronic hyperglycaemia reduce, but do not eradicate, the risk of these complications. Success in defining new preventative and therapeutic strategies hinges on an improved understanding of the molecular processes involved in the development of these complications. This Review explores the role of human genetics in delivering such insights, and describes progress in characterizing the sequence variants that influence individual predisposition to... (More)
The rising global prevalence of diabetes mellitus is accompanied by an increasing burden of morbidity and mortality that is attributable to the complications of chronic hyperglycaemia. These complications include blindness, renal failure and cardiovascular disease. Current therapeutic options for chronic hyperglycaemia reduce, but do not eradicate, the risk of these complications. Success in defining new preventative and therapeutic strategies hinges on an improved understanding of the molecular processes involved in the development of these complications. This Review explores the role of human genetics in delivering such insights, and describes progress in characterizing the sequence variants that influence individual predisposition to diabetic kidney disease, retinopathy, neuropathy and accelerated cardiovascular disease. Numerous risk variants for microvascular complications of diabetes have been reported, but very few have shown robust replication. Furthermore, only limited evidence exists of a difference in the repertoire of risk variants influencing macrovascular disease between those with and those without diabetes. Here, we outline the challenges associated with the genetic analysis of diabetic complications and highlight ongoing efforts to deliver biological insights that can drive translational benefits. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews Nephrology
volume
11
issue
5
pages
277 - 287
publisher
Nature Publishing Group
external identifiers
  • pmid:25825086
  • wos:000353585600006
  • scopus:84929134635
ISSN
1759-507X
DOI
10.1038/nrneph.2015.37
language
English
LU publication?
yes
id
c6dd8c04-1c5d-470a-a51a-c686efff15f5 (old id 5360738)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25825086?dopt=Abstract
date added to LUP
2015-05-07 19:38:17
date last changed
2017-11-19 03:04:56
@article{c6dd8c04-1c5d-470a-a51a-c686efff15f5,
  abstract     = {The rising global prevalence of diabetes mellitus is accompanied by an increasing burden of morbidity and mortality that is attributable to the complications of chronic hyperglycaemia. These complications include blindness, renal failure and cardiovascular disease. Current therapeutic options for chronic hyperglycaemia reduce, but do not eradicate, the risk of these complications. Success in defining new preventative and therapeutic strategies hinges on an improved understanding of the molecular processes involved in the development of these complications. This Review explores the role of human genetics in delivering such insights, and describes progress in characterizing the sequence variants that influence individual predisposition to diabetic kidney disease, retinopathy, neuropathy and accelerated cardiovascular disease. Numerous risk variants for microvascular complications of diabetes have been reported, but very few have shown robust replication. Furthermore, only limited evidence exists of a difference in the repertoire of risk variants influencing macrovascular disease between those with and those without diabetes. Here, we outline the challenges associated with the genetic analysis of diabetic complications and highlight ongoing efforts to deliver biological insights that can drive translational benefits.},
  author       = {Ahlqvist, Emma and van Zuydam, Natalie R and Groop, Leif and McCarthy, Mark I},
  issn         = {1759-507X},
  language     = {eng},
  number       = {5},
  pages        = {277--287},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews Nephrology},
  title        = {The genetics of diabetic complications.},
  url          = {http://dx.doi.org/10.1038/nrneph.2015.37},
  volume       = {11},
  year         = {2015},
}