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Translational value of animal models of asthma: Challenges and promises.

Sagar, Seil LU ; Akbarshahi, Hamid LU and Uller, Lena LU (2015) In European Journal of Pharmacology 759(Mar 28). p.272-277
Abstract
Asthma is a heterogeneous disease in which various environmental stimuli as well as different genes, cell types, cytokines and mediators are implicated. This chronic inflammatory disorder of the airways is estimated to affect as many as 300 million people worldwide. Animal models of asthma, despite their limitations, have contributed greatly to our understanding of disease pathology and the identification of key processes, cells and mediators in asthma. However, it is less likely to develop an animal model of asthma that takes into account all aspects of human disease. The focus in current asthma research is increasingly on severe asthma because this group of patients is not well treated today. Recent advances in studies of asthma... (More)
Asthma is a heterogeneous disease in which various environmental stimuli as well as different genes, cell types, cytokines and mediators are implicated. This chronic inflammatory disorder of the airways is estimated to affect as many as 300 million people worldwide. Animal models of asthma, despite their limitations, have contributed greatly to our understanding of disease pathology and the identification of key processes, cells and mediators in asthma. However, it is less likely to develop an animal model of asthma that takes into account all aspects of human disease. The focus in current asthma research is increasingly on severe asthma because this group of patients is not well treated today. Recent advances in studies of asthma exacerbation are thus considered. We therefore need to develop translational model systems for pharmacological evaluation and molecular target discovery of severe asthma and asthma exacerbations. In this review we attempted to discuss the different animal models of asthma, with special emphasis on ovalbumin and house dust mite models, their merits and their limitations. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Pharmacology
volume
759
issue
Mar 28
pages
272 - 277
publisher
Elsevier
external identifiers
  • pmid:25823808
  • wos:000355362500028
  • scopus:84937762632
ISSN
1879-0712
DOI
10.1016/j.ejphar.2015.03.037
language
English
LU publication?
yes
id
4470dac6-40d9-44da-ac76-a1816f43fad1 (old id 5360782)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25823808?dopt=Abstract
date added to LUP
2015-05-07 20:02:26
date last changed
2017-08-13 03:21:12
@article{4470dac6-40d9-44da-ac76-a1816f43fad1,
  abstract     = {Asthma is a heterogeneous disease in which various environmental stimuli as well as different genes, cell types, cytokines and mediators are implicated. This chronic inflammatory disorder of the airways is estimated to affect as many as 300 million people worldwide. Animal models of asthma, despite their limitations, have contributed greatly to our understanding of disease pathology and the identification of key processes, cells and mediators in asthma. However, it is less likely to develop an animal model of asthma that takes into account all aspects of human disease. The focus in current asthma research is increasingly on severe asthma because this group of patients is not well treated today. Recent advances in studies of asthma exacerbation are thus considered. We therefore need to develop translational model systems for pharmacological evaluation and molecular target discovery of severe asthma and asthma exacerbations. In this review we attempted to discuss the different animal models of asthma, with special emphasis on ovalbumin and house dust mite models, their merits and their limitations.},
  author       = {Sagar, Seil and Akbarshahi, Hamid and Uller, Lena},
  issn         = {1879-0712},
  language     = {eng},
  number       = {Mar 28},
  pages        = {272--277},
  publisher    = {Elsevier},
  series       = {European Journal of Pharmacology},
  title        = {Translational value of animal models of asthma: Challenges and promises.},
  url          = {http://dx.doi.org/10.1016/j.ejphar.2015.03.037},
  volume       = {759},
  year         = {2015},
}