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Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion.

Csáti, A ; Edvinsson, Lars LU ; Vécsei, L ; Toldi, J ; Fülöp, F ; Tajti, J and Warfvinge, Karin LU orcid (2015) In Journal of Headache and Pain 16(99).
Abstract
The trigeminal ganglion (TG) plays a central role in cranial pain. Administration of complete Freund's adjuvant (CFA) into the temporomandibular joint (TMJ) elicits activation of TG. Kynurenic acid (KYNA) is an endogenous excitatory amino acid receptor blocker, which may have an anti-inflammatory effect. We hypothesize that KYNA may reduce CFA-induced activation within the TG.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Headache and Pain
volume
16
issue
99
article number
99
publisher
Springer
external identifiers
  • pmid:26627709
  • wos:000368626000001
  • scopus:84948955616
  • pmid:26627709
ISSN
1129-2369
DOI
10.1186/s10194-015-0581-x
language
English
LU publication?
yes
id
53690eb8-820c-46eb-bba1-9d99605c9516 (old id 8505868)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26627709?dopt=Abstract
date added to LUP
2016-04-01 10:45:19
date last changed
2024-01-07 00:21:48
@article{53690eb8-820c-46eb-bba1-9d99605c9516,
  abstract     = {{The trigeminal ganglion (TG) plays a central role in cranial pain. Administration of complete Freund's adjuvant (CFA) into the temporomandibular joint (TMJ) elicits activation of TG. Kynurenic acid (KYNA) is an endogenous excitatory amino acid receptor blocker, which may have an anti-inflammatory effect. We hypothesize that KYNA may reduce CFA-induced activation within the TG.}},
  author       = {{Csáti, A and Edvinsson, Lars and Vécsei, L and Toldi, J and Fülöp, F and Tajti, J and Warfvinge, Karin}},
  issn         = {{1129-2369}},
  language     = {{eng}},
  number       = {{99}},
  publisher    = {{Springer}},
  series       = {{Journal of Headache and Pain}},
  title        = {{Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion.}},
  url          = {{http://dx.doi.org/10.1186/s10194-015-0581-x}},
  doi          = {{10.1186/s10194-015-0581-x}},
  volume       = {{16}},
  year         = {{2015}},
}