Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status.
(2013) In Cancer Causes and Control 24(5). p.929-940- Abstract
- PURPOSE: Whether coffee modulates response to endocrine therapy in breast cancer patients is currently unknown. The CYP1A2 and CYP2C8 enzymes contribute to tamoxifen and caffeine metabolism. The purpose was to investigate the impact of coffee consumption on tumor characteristics and risk for early events in relation to breast cancer treatment and CYP1A2 and CYP2C8 genotypes. METHODS: Questionnaires regarding lifestyle were completed preoperatively by 634 patients in southern Sweden. CYP1A2*1F and CYP2C8*3 were genotyped. Clinical data and tumor characteristics were obtained from patients' charts, population registries, and pathology reports. Coffee consumption was categorized as low (0-1 cups/day), moderate (2-4 cups/day), or high (5+... (More)
- PURPOSE: Whether coffee modulates response to endocrine therapy in breast cancer patients is currently unknown. The CYP1A2 and CYP2C8 enzymes contribute to tamoxifen and caffeine metabolism. The purpose was to investigate the impact of coffee consumption on tumor characteristics and risk for early events in relation to breast cancer treatment and CYP1A2 and CYP2C8 genotypes. METHODS: Questionnaires regarding lifestyle were completed preoperatively by 634 patients in southern Sweden. CYP1A2*1F and CYP2C8*3 were genotyped. Clinical data and tumor characteristics were obtained from patients' charts, population registries, and pathology reports. Coffee consumption was categorized as low (0-1 cups/day), moderate (2-4 cups/day), or high (5+ cups/day). RESULTS: The proportion of estrogen receptor negative (ER-) tumors increased with increasing coffee consumption (p (trend) = 0.042). Moderate to high consumption was associated with lower frequency of discordant receptor status (ER + PgR-) OR 0.38 (0.23-0.63) compared to low consumption. Median follow-up time was 4.92 (IQR 3.01-6.42) years. Tamoxifen-treated patients with ER+ tumors (n = 310) who consumed two or more cups/day had significantly decreased risk for early events compared to patients with low consumption, adjusted HR 0.40 (0.19-0.83). Low consumption combined with at least one CYP1A2*1F C-allele (n = 35) or CYP2C8*3 (n = 13) was associated with a high risk for early events in tamoxifen-treated patients compared to other tamoxifen-treated patients, adjusted HRs 3.49 (1.54-7.91) and 6.15 (2.46-15.36), respectively. CONCLUSION: Moderate to high coffee consumption was associated with significantly decreased risk for early events in tamoxifen-treated patients and modified hormone receptor status. If confirmed, new recommendations regarding coffee consumption during tamoxifen treatment may be warranted. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3559729
- author
- Simonsson, Maria LU ; Söderlind, Viktoria ; Henningson, Maria LU ; Hjertberg, Maria ; Rose, Carsten LU ; Ingvar, Christian LU and Jernström, Helena LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Causes and Control
- volume
- 24
- issue
- 5
- pages
- 929 - 940
- publisher
- Springer
- external identifiers
-
- wos:000317975800010
- pmid:23412805
- scopus:84892794443
- ISSN
- 1573-7225
- DOI
- 10.1007/s10552-013-0169-1
- language
- English
- LU publication?
- yes
- id
- 53850f25-abf0-46a0-8d13-08cdbc43613c (old id 3559729)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23412805?dopt=Abstract
- date added to LUP
- 2016-04-01 11:08:13
- date last changed
- 2022-04-28 07:38:23
@article{53850f25-abf0-46a0-8d13-08cdbc43613c,
abstract = {{PURPOSE: Whether coffee modulates response to endocrine therapy in breast cancer patients is currently unknown. The CYP1A2 and CYP2C8 enzymes contribute to tamoxifen and caffeine metabolism. The purpose was to investigate the impact of coffee consumption on tumor characteristics and risk for early events in relation to breast cancer treatment and CYP1A2 and CYP2C8 genotypes. METHODS: Questionnaires regarding lifestyle were completed preoperatively by 634 patients in southern Sweden. CYP1A2*1F and CYP2C8*3 were genotyped. Clinical data and tumor characteristics were obtained from patients' charts, population registries, and pathology reports. Coffee consumption was categorized as low (0-1 cups/day), moderate (2-4 cups/day), or high (5+ cups/day). RESULTS: The proportion of estrogen receptor negative (ER-) tumors increased with increasing coffee consumption (p (trend) = 0.042). Moderate to high consumption was associated with lower frequency of discordant receptor status (ER + PgR-) OR 0.38 (0.23-0.63) compared to low consumption. Median follow-up time was 4.92 (IQR 3.01-6.42) years. Tamoxifen-treated patients with ER+ tumors (n = 310) who consumed two or more cups/day had significantly decreased risk for early events compared to patients with low consumption, adjusted HR 0.40 (0.19-0.83). Low consumption combined with at least one CYP1A2*1F C-allele (n = 35) or CYP2C8*3 (n = 13) was associated with a high risk for early events in tamoxifen-treated patients compared to other tamoxifen-treated patients, adjusted HRs 3.49 (1.54-7.91) and 6.15 (2.46-15.36), respectively. CONCLUSION: Moderate to high coffee consumption was associated with significantly decreased risk for early events in tamoxifen-treated patients and modified hormone receptor status. If confirmed, new recommendations regarding coffee consumption during tamoxifen treatment may be warranted.}},
author = {{Simonsson, Maria and Söderlind, Viktoria and Henningson, Maria and Hjertberg, Maria and Rose, Carsten and Ingvar, Christian and Jernström, Helena}},
issn = {{1573-7225}},
language = {{eng}},
number = {{5}},
pages = {{929--940}},
publisher = {{Springer}},
series = {{Cancer Causes and Control}},
title = {{Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status.}},
url = {{https://lup.lub.lu.se/search/files/2405236/3768327.pdf}},
doi = {{10.1007/s10552-013-0169-1}},
volume = {{24}},
year = {{2013}},
}