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Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats

Taveau, Christopher; Chollet, Catherine; Waeckel, Ludovic; Desposito, Dorinne; Bichet, Daniel G.; Arthus, Marie-Francoise; Magnan, Christophe; Philippe, Erwann; Paradis, Valerie and Foufelle, Fabienne, et al. (2015) In Diabetologia 58(5). p.1081-1090
Abstract
Aims/hypothesis High plasma copeptin, a marker of vasopressin (VP) secretion, has been shown to be associated with the metabolic syndrome and development of type 2 diabetes in humans. The present study was designed to determine the long-term influence of plasma VP concentration in a rodent model prone to metabolic dysfunction. Methods Obese Zucker rats and their lean counterparts were submitted for 4 weeks to one of three protocols inducing different levels of VP. Circulating VP was either reduced by increasing the daily water intake (low-VP), or increased by a chronic i.p. infusion of VP (high-VP). The control rats had normal VP levels that depended on their own regulation of water intake and VP secretion. Results Compared with controls... (More)
Aims/hypothesis High plasma copeptin, a marker of vasopressin (VP) secretion, has been shown to be associated with the metabolic syndrome and development of type 2 diabetes in humans. The present study was designed to determine the long-term influence of plasma VP concentration in a rodent model prone to metabolic dysfunction. Methods Obese Zucker rats and their lean counterparts were submitted for 4 weeks to one of three protocols inducing different levels of VP. Circulating VP was either reduced by increasing the daily water intake (low-VP), or increased by a chronic i.p. infusion of VP (high-VP). The control rats had normal VP levels that depended on their own regulation of water intake and VP secretion. Results Compared with controls with normal VP, lean rats with high-VP had a higher fasting glycaemia after 4 weeks. In obese rats, high-VP promoted hyperinsulinaemia, glucose intolerance, assessed by glucose and insulin tolerance tests, and an impaired response to a pyruvate challenge. Conversely, treatment with a selective arginine vasopressin receptor 1A (V1aR) antagonist reduced glucose intolerance. Low-VP obese rats had unchanged glucose tolerance but exhibited a drastic decrease in liver steatosis compared with control obese rats, associated with low hepatic triacylglycerol and cholesterol content, and reduced expression of hepatic lipogenic genes. These effects were independent of changes in body adiposity, and plasma sodium and osmolality did not differ among groups. Conclusion/interpretation These findings show a causal relationship between the VP-hydration axis and the metabolic risk. Therapeutic perspectives include diet recommendations regarding hydration, but also potential pharmacological interventions targeting the VP V1aR. (Less)
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Contribution to journal
publication status
published
subject
keywords
Glucosemetabolism, Hydration, Lipid metabolism, Liver, Vasopressin
in
Diabetologia
volume
58
issue
5
pages
1081 - 1090
publisher
Springer Verlag
external identifiers
  • wos:000352644200025
  • scopus:84939976662
ISSN
1432-0428
DOI
10.1007/s00125-015-3496-9
language
English
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yes
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82fd37a6-41cd-4f27-bd55-cd057c7522d7 (old id 5386061)
date added to LUP
2015-06-01 09:26:44
date last changed
2017-10-01 03:05:04
@article{82fd37a6-41cd-4f27-bd55-cd057c7522d7,
  abstract     = {Aims/hypothesis High plasma copeptin, a marker of vasopressin (VP) secretion, has been shown to be associated with the metabolic syndrome and development of type 2 diabetes in humans. The present study was designed to determine the long-term influence of plasma VP concentration in a rodent model prone to metabolic dysfunction. Methods Obese Zucker rats and their lean counterparts were submitted for 4 weeks to one of three protocols inducing different levels of VP. Circulating VP was either reduced by increasing the daily water intake (low-VP), or increased by a chronic i.p. infusion of VP (high-VP). The control rats had normal VP levels that depended on their own regulation of water intake and VP secretion. Results Compared with controls with normal VP, lean rats with high-VP had a higher fasting glycaemia after 4 weeks. In obese rats, high-VP promoted hyperinsulinaemia, glucose intolerance, assessed by glucose and insulin tolerance tests, and an impaired response to a pyruvate challenge. Conversely, treatment with a selective arginine vasopressin receptor 1A (V1aR) antagonist reduced glucose intolerance. Low-VP obese rats had unchanged glucose tolerance but exhibited a drastic decrease in liver steatosis compared with control obese rats, associated with low hepatic triacylglycerol and cholesterol content, and reduced expression of hepatic lipogenic genes. These effects were independent of changes in body adiposity, and plasma sodium and osmolality did not differ among groups. Conclusion/interpretation These findings show a causal relationship between the VP-hydration axis and the metabolic risk. Therapeutic perspectives include diet recommendations regarding hydration, but also potential pharmacological interventions targeting the VP V1aR.},
  author       = {Taveau, Christopher and Chollet, Catherine and Waeckel, Ludovic and Desposito, Dorinne and Bichet, Daniel G. and Arthus, Marie-Francoise and Magnan, Christophe and Philippe, Erwann and Paradis, Valerie and Foufelle, Fabienne and Hainault, Isabelle and Enhörning, Sofia and Velho, Gilberto and Roussel, Ronan and Bankir, Lise and Melander, Olle and Bouby, Nadine},
  issn         = {1432-0428},
  keyword      = {Glucosemetabolism,Hydration,Lipid metabolism,Liver,Vasopressin},
  language     = {eng},
  number       = {5},
  pages        = {1081--1090},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats},
  url          = {http://dx.doi.org/10.1007/s00125-015-3496-9},
  volume       = {58},
  year         = {2015},
}