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Cortical and striatal circuits together encode transitions in natural behavior

Sjöbom, Joel LU orcid ; Tamtè, Martin LU ; Halje, Pär LU ; Brys, Ivani LU and Petersson, Per LU (2020) In Science Advances 6(41).
Abstract

In natural behavior, we fluidly change from one type of activity to another in a sequence of motor actions. Corticostriatal circuits are thought to have a particularly important role in the construction of action sequences, but neuronal coding of a sequential behavior consisting of different motor programs has not been investigated at the circuit level in corticostriatal networks, making the exact nature of this involvement elusive. Here, we show, by analyzing spontaneous self-grooming in rats, that neuronal modulation in motor cortex and dorsal striatum is strongly related to transitions between behaviors. Our data suggest that longer action sequences in rodent grooming behavior emerge from stepwise control of individual behavioral... (More)

In natural behavior, we fluidly change from one type of activity to another in a sequence of motor actions. Corticostriatal circuits are thought to have a particularly important role in the construction of action sequences, but neuronal coding of a sequential behavior consisting of different motor programs has not been investigated at the circuit level in corticostriatal networks, making the exact nature of this involvement elusive. Here, we show, by analyzing spontaneous self-grooming in rats, that neuronal modulation in motor cortex and dorsal striatum is strongly related to transitions between behaviors. Our data suggest that longer action sequences in rodent grooming behavior emerge from stepwise control of individual behavioral transitions, where future actions are encoded differently depending on current motor state. This state-dependent motor coding was found to differentiate between rare behavioral transitions and as opposed to more habitual sequencing of actions.

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Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Science Advances
volume
6
issue
41
article number
eabc1173
publisher
American Association for the Advancement of Science (AAAS)
external identifiers
  • scopus:85092754305
  • pmid:33036974
ISSN
2375-2548
DOI
10.1126/sciadv.abc1173
language
English
LU publication?
yes
id
53900a89-0ebd-480c-b126-b5ce2ffa495b
date added to LUP
2020-11-09 10:13:24
date last changed
2024-05-29 23:14:47
@article{53900a89-0ebd-480c-b126-b5ce2ffa495b,
  abstract     = {{<p>In natural behavior, we fluidly change from one type of activity to another in a sequence of motor actions. Corticostriatal circuits are thought to have a particularly important role in the construction of action sequences, but neuronal coding of a sequential behavior consisting of different motor programs has not been investigated at the circuit level in corticostriatal networks, making the exact nature of this involvement elusive. Here, we show, by analyzing spontaneous self-grooming in rats, that neuronal modulation in motor cortex and dorsal striatum is strongly related to transitions between behaviors. Our data suggest that longer action sequences in rodent grooming behavior emerge from stepwise control of individual behavioral transitions, where future actions are encoded differently depending on current motor state. This state-dependent motor coding was found to differentiate between rare behavioral transitions and as opposed to more habitual sequencing of actions.</p>}},
  author       = {{Sjöbom, Joel and Tamtè, Martin and Halje, Pär and Brys, Ivani and Petersson, Per}},
  issn         = {{2375-2548}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{41}},
  publisher    = {{American Association for the Advancement of Science (AAAS)}},
  series       = {{Science Advances}},
  title        = {{Cortical and striatal circuits together encode transitions in natural behavior}},
  url          = {{http://dx.doi.org/10.1126/sciadv.abc1173}},
  doi          = {{10.1126/sciadv.abc1173}},
  volume       = {{6}},
  year         = {{2020}},
}