Activation of extracellular-signal-regulated kinase-1/2 precedes and is required for injury-induced Schwann cell proliferation.
(2007) In NeuroReport 18(10). p.957-961- Abstract
- Activation of extracellular-signal-regulated kinase-1/2 (Erkl/2) by phosphorylation to p-Erkl/2, and proliferation of Schwann cells were investigated in the rat sciatic nerve by immunohistochemistry. Axotomy in vivo and culturing of nerve segments in vitro resulted in a rapid (30 min) increase of p-Erkl/2 in Schwann cells with peaks at 2 and 24 h. Proliferation measured by bromodeoxy uridine incorporation and immunostaining in vivo and in vitro 48 h after axotomy showed an increase in Schwann cell proliferation at the sites of Erkl/2 activation. The Erkl/2 inhibitor U0126 inhibited both the increase in p-Erkl/2 and the bromodeoxy uridine incorporation. We suggest that an increase in p-Erkl/2 is required for nerve injury-induced... (More)
- Activation of extracellular-signal-regulated kinase-1/2 (Erkl/2) by phosphorylation to p-Erkl/2, and proliferation of Schwann cells were investigated in the rat sciatic nerve by immunohistochemistry. Axotomy in vivo and culturing of nerve segments in vitro resulted in a rapid (30 min) increase of p-Erkl/2 in Schwann cells with peaks at 2 and 24 h. Proliferation measured by bromodeoxy uridine incorporation and immunostaining in vivo and in vitro 48 h after axotomy showed an increase in Schwann cell proliferation at the sites of Erkl/2 activation. The Erkl/2 inhibitor U0126 inhibited both the increase in p-Erkl/2 and the bromodeoxy uridine incorporation. We suggest that an increase in p-Erkl/2 is required for nerve injury-induced proliferation of Schwann cells. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/539902
- author
- Mårtensson, Lisa LU ; Gustavsson, Per LU ; Dahlin, Lars B and Kanje, Martin LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Erk map kinases, cellular proliferation, nerve injury, regeneration, phosphorylation, Schwann cells, nerve
- in
- NeuroReport
- volume
- 18
- issue
- 10
- pages
- 957 - 961
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000247629000003
- scopus:34250192938
- ISSN
- 1473-558X
- project
- Nerve regeneration - signal transduktion mechanisms, timing and alternatives to nerve grafts
- language
- English
- LU publication?
- yes
- id
- fd7f305d-fa89-45ce-8138-a239c0e280d8 (old id 539902)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17558277&dopt=Abstract
- date added to LUP
- 2016-04-04 07:20:31
- date last changed
- 2022-01-29 02:05:47
@article{fd7f305d-fa89-45ce-8138-a239c0e280d8,
abstract = {{Activation of extracellular-signal-regulated kinase-1/2 (Erkl/2) by phosphorylation to p-Erkl/2, and proliferation of Schwann cells were investigated in the rat sciatic nerve by immunohistochemistry. Axotomy in vivo and culturing of nerve segments in vitro resulted in a rapid (30 min) increase of p-Erkl/2 in Schwann cells with peaks at 2 and 24 h. Proliferation measured by bromodeoxy uridine incorporation and immunostaining in vivo and in vitro 48 h after axotomy showed an increase in Schwann cell proliferation at the sites of Erkl/2 activation. The Erkl/2 inhibitor U0126 inhibited both the increase in p-Erkl/2 and the bromodeoxy uridine incorporation. We suggest that an increase in p-Erkl/2 is required for nerve injury-induced proliferation of Schwann cells.}},
author = {{Mårtensson, Lisa and Gustavsson, Per and Dahlin, Lars B and Kanje, Martin}},
issn = {{1473-558X}},
keywords = {{Erk map kinases; cellular proliferation; nerve injury; regeneration; phosphorylation; Schwann cells; nerve}},
language = {{eng}},
number = {{10}},
pages = {{957--961}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{NeuroReport}},
title = {{Activation of extracellular-signal-regulated kinase-1/2 precedes and is required for injury-induced Schwann cell proliferation.}},
url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17558277&dopt=Abstract}},
volume = {{18}},
year = {{2007}},
}