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Activation of extracellular-signal-regulated kinase-1/2 precedes and is required for injury-induced Schwann cell proliferation.

Mårtensson, Lisa LU ; Gustavsson, Per LU ; Dahlin, Lars B and Kanje, Martin LU (2007) In NeuroReport 18(10). p.957-961
Abstract
Activation of extracellular-signal-regulated kinase-1/2 (Erkl/2) by phosphorylation to p-Erkl/2, and proliferation of Schwann cells were investigated in the rat sciatic nerve by immunohistochemistry. Axotomy in vivo and culturing of nerve segments in vitro resulted in a rapid (30 min) increase of p-Erkl/2 in Schwann cells with peaks at 2 and 24 h. Proliferation measured by bromodeoxy uridine incorporation and immunostaining in vivo and in vitro 48 h after axotomy showed an increase in Schwann cell proliferation at the sites of Erkl/2 activation. The Erkl/2 inhibitor U0126 inhibited both the increase in p-Erkl/2 and the bromodeoxy uridine incorporation. We suggest that an increase in p-Erkl/2 is required for nerve injury-induced... (More)
Activation of extracellular-signal-regulated kinase-1/2 (Erkl/2) by phosphorylation to p-Erkl/2, and proliferation of Schwann cells were investigated in the rat sciatic nerve by immunohistochemistry. Axotomy in vivo and culturing of nerve segments in vitro resulted in a rapid (30 min) increase of p-Erkl/2 in Schwann cells with peaks at 2 and 24 h. Proliferation measured by bromodeoxy uridine incorporation and immunostaining in vivo and in vitro 48 h after axotomy showed an increase in Schwann cell proliferation at the sites of Erkl/2 activation. The Erkl/2 inhibitor U0126 inhibited both the increase in p-Erkl/2 and the bromodeoxy uridine incorporation. We suggest that an increase in p-Erkl/2 is required for nerve injury-induced proliferation of Schwann cells. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Erk map kinases, cellular proliferation, nerve injury, regeneration, phosphorylation, Schwann cells, nerve
in
NeuroReport
volume
18
issue
10
pages
957 - 961
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000247629000003
  • scopus:34250192938
ISSN
1473-558X
language
English
LU publication?
yes
id
fd7f305d-fa89-45ce-8138-a239c0e280d8 (old id 539902)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17558277&dopt=Abstract
date added to LUP
2007-12-14 16:34:38
date last changed
2017-11-19 04:16:42
@article{fd7f305d-fa89-45ce-8138-a239c0e280d8,
  abstract     = {Activation of extracellular-signal-regulated kinase-1/2 (Erkl/2) by phosphorylation to p-Erkl/2, and proliferation of Schwann cells were investigated in the rat sciatic nerve by immunohistochemistry. Axotomy in vivo and culturing of nerve segments in vitro resulted in a rapid (30 min) increase of p-Erkl/2 in Schwann cells with peaks at 2 and 24 h. Proliferation measured by bromodeoxy uridine incorporation and immunostaining in vivo and in vitro 48 h after axotomy showed an increase in Schwann cell proliferation at the sites of Erkl/2 activation. The Erkl/2 inhibitor U0126 inhibited both the increase in p-Erkl/2 and the bromodeoxy uridine incorporation. We suggest that an increase in p-Erkl/2 is required for nerve injury-induced proliferation of Schwann cells.},
  author       = {Mårtensson, Lisa and Gustavsson, Per and Dahlin, Lars B and Kanje, Martin},
  issn         = {1473-558X},
  keyword      = {Erk map kinases,cellular proliferation,nerve injury,regeneration,phosphorylation,Schwann cells,nerve},
  language     = {eng},
  number       = {10},
  pages        = {957--961},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Activation of extracellular-signal-regulated kinase-1/2 precedes and is required for injury-induced Schwann cell proliferation.},
  volume       = {18},
  year         = {2007},
}